SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uss'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 4uss GLUTATHIONYL
HYDROQUINONE
REDUCTASE
(Populus
trichocarpa) 		5 / 12 ALA A 160
PHE A 152
PHE A  25
LEU A 132
ILE A  68
 None
 1.06A 1cd2A-4ussA:
undetectable		 1cd2A-4ussA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA734_1
(ALPHA AMYLASE)		 4uss GLUTATHIONYL
HYDROQUINONE
REDUCTASE
(Populus
trichocarpa) 		4 / 6 HIS A 292
TYR A 293
GLY A 295
TRP A  77
 None
None
None
GSH  A 500 ( 4.1A)
 0.90A 1mxdA-4ussA:
undetectable		 1mxdA-4ussA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 4uss GLUTATHIONYL
HYDROQUINONE
REDUCTASE
(Populus
trichocarpa) 		4 / 7 HIS A 292
TYR A 293
GLY A 295
TRP A  77
 None
None
None
GSH  A 500 ( 4.1A)
 0.91A 1mxgA-4ussA:
undetectable		 1mxgA-4ussA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_A_SAMA1501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 4uss GLUTATHIONYL
HYDROQUINONE
REDUCTASE
(Populus
trichocarpa) 		4 / 7 GLU A 117
THR A  80
SER A 111
VAL A  73
 None
 1.21A 1tv8A-4ussA:
undetectable		 1tv8A-4ussA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_B_SAMB501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 4uss GLUTATHIONYL
HYDROQUINONE
REDUCTASE
(Populus
trichocarpa) 		4 / 7 GLU A 117
THR A  80
SER A 111
VAL A  73
 None
 1.21A 2fb2B-4ussA:
undetectable		 2fb2B-4ussA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)		 4uss GLUTATHIONYL
HYDROQUINONE
REDUCTASE
(Populus
trichocarpa) 		5 / 12 VAL A  73
PRO A  50
SER A  53
VAL A  45
VAL A 129
 None
None
None
None
GSH  A 500 (-3.8A)
 1.12A 3iw1A-4ussA:
undetectable		 3iw1A-4ussA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 4uss GLUTATHIONYL
HYDROQUINONE
REDUCTASE
(Populus
trichocarpa) 		4 / 6 ARG A  54
PRO A 130
GLU A 144
SER A 145
 None
GSH  A 500 (-4.3A)
GSH  A 500 (-2.8A)
GSH  A 500 (-2.7A)
 0.80A 3vlnA-4ussA:
17.6		 3vlnA-4ussA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4uss GLUTATHIONYL
HYDROQUINONE
REDUCTASE
(Populus
trichocarpa) 		4 / 5 LEU A 221
THR A 179
ILE A 187
VAL A 183
 None
 0.92A 3wriA-4ussA:
undetectable		 3wriA-4ussA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G10_A_ACTA301_0
(GLUTATHIONE
S-TRANSFERASE
HOMOLOG)		 4uss GLUTATHIONYL
HYDROQUINONE
REDUCTASE
(Populus
trichocarpa) 		4 / 6 PRO A  50
ILE A 244
TYR A 293
TYR A 250
 None
 1.22A 4g10A-4ussA:
15.9		 4g10A-4ussA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 4uss GLUTATHIONYL
HYDROQUINONE
REDUCTASE
(Populus
trichocarpa) 		3 / 3 ASN A 157
PHE A 152
TYR A  41
 None
 0.85A 4u15A-4ussA:
undetectable		 4u15A-4ussA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJE_A_TOYA202_1
(AADB)		 4uss GLUTATHIONYL
HYDROQUINONE
REDUCTASE
(Populus
trichocarpa) 		4 / 8 TYR A 168
ASP A 177
GLU A 234
ILE A 149
 None
 0.99A 4xjeA-4ussA:
undetectable		 4xjeA-4ussA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 4uss GLUTATHIONYL
HYDROQUINONE
REDUCTASE
(Populus
trichocarpa) 		3 / 4 ARG A 110
GLY A 108
GLU A 114
 None
 0.61A 4z2dB-4ussA:
undetectable
4z2dC-4ussA:
undetectable		 4z2dB-4ussA:
19.80
4z2dC-4ussA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		 4uss GLUTATHIONYL
HYDROQUINONE
REDUCTASE
(Populus
trichocarpa) 		4 / 8 TYR A 168
ASP A 177
GLU A 234
ILE A 149
 None
 1.06A 5cfsA-4ussA:
undetectable		 5cfsA-4ussA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		 4uss GLUTATHIONYL
HYDROQUINONE
REDUCTASE
(Populus
trichocarpa) 		4 / 6 ALA A 235
LEU A 239
TYR A 270
SER A 233
 None
 1.11A 5phhA-4ussA:
undetectable		 5phhA-4ussA:
22.73