SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ut1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 4ut1 FLAGELLAR
HOOK-ASSOCIATED
PROTEIN
(Burkholderia
pseudomallei) 		6 / 12 ARG A 156
ALA A 148
LEU A 425
LEU A 304
ILE A 107
MET A 580
 None
EDO  A1642 ( 4.3A)
None
None
EDO  A1642 (-4.3A)
None
 1.40A 1bsxA-4ut1A:
undetectable		 1bsxA-4ut1A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 4ut1 FLAGELLAR
HOOK-ASSOCIATED
PROTEIN
(Burkholderia
pseudomallei) 		6 / 12 ARG A 156
ALA A 148
LEU A 425
LEU A 304
ILE A 107
MET A 580
 None
EDO  A1642 ( 4.3A)
None
None
EDO  A1642 (-4.3A)
None
 1.40A 1bsxB-4ut1A:
undetectable		 1bsxB-4ut1A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 4ut1 FLAGELLAR
HOOK-ASSOCIATED
PROTEIN
(Burkholderia
pseudomallei) 		5 / 10 ALA A 424
PHE A 428
GLY A 427
LEU A 304
PRO A 360
 None
None
EDO  A1645 ( 4.3A)
None
None
 1.32A 1cmcA-4ut1A:
undetectable
1cmcB-4ut1A:
undetectable		 1cmcA-4ut1A:
10.20
1cmcB-4ut1A:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 4ut1 FLAGELLAR
HOOK-ASSOCIATED
PROTEIN
(Burkholderia
pseudomallei) 		4 / 6 LEU A 278
ALA A 212
SER A  85
THR A  81
 None
 0.94A 1ictB-4ut1A:
undetectable		 1ictB-4ut1A:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1121_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4ut1 FLAGELLAR
HOOK-ASSOCIATED
PROTEIN
(Burkholderia
pseudomallei) 		4 / 5 SER A 224
VAL A 235
SER A 219
VAL A 217
 None
 1.35A 2j9cA-4ut1A:
undetectable
2j9cB-4ut1A:
undetectable
2j9cC-4ut1A:
undetectable		 2j9cA-4ut1A:
8.79
2j9cB-4ut1A:
8.79
2j9cC-4ut1A:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_1
(MINERALOCORTICOID
RECEPTOR)		 4ut1 FLAGELLAR
HOOK-ASSOCIATED
PROTEIN
(Burkholderia
pseudomallei) 		5 / 12 ASN A 137
LEU A 141
ALA A 138
LEU A 571
THR A 120
 EDO  A1634 ( 3.2A)
None
None
None
None
 1.36A 2oaxF-4ut1A:
undetectable		 2oaxF-4ut1A:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ut1 FLAGELLAR
HOOK-ASSOCIATED
PROTEIN
(Burkholderia
pseudomallei) 		5 / 9 GLN A 241
ALA A 262
ASN A 171
LEU A 208
ILE A 170
 EDO  A1631 (-3.8A)
EDO  A1631 (-3.2A)
EDO  A1631 (-4.4A)
None
None
 1.35A 3claA-4ut1A:
undetectable		 3claA-4ut1A:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 4ut1 FLAGELLAR
HOOK-ASSOCIATED
PROTEIN
(Burkholderia
pseudomallei) 		5 / 12 LEU A 571
GLY A 328
GLY A 327
PRO A 326
ALA A 314
 None
 0.98A 3i5uA-4ut1A:
undetectable		 3i5uA-4ut1A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 4ut1 FLAGELLAR
HOOK-ASSOCIATED
PROTEIN
(Burkholderia
pseudomallei) 		5 / 12 LEU A 571
GLY A 328
GLY A 327
PRO A 326
ALA A 314
 None
 0.99A 3i5uB-4ut1A:
undetectable		 3i5uB-4ut1A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 4ut1 FLAGELLAR
HOOK-ASSOCIATED
PROTEIN
(Burkholderia
pseudomallei) 		5 / 10 SER A 383
LEU A 367
SER A 368
ILE A 399
GLY A 386
 None
 1.35A 3ijxB-4ut1A:
undetectable
3ijxD-4ut1A:
undetectable		 3ijxB-4ut1A:
16.17
3ijxD-4ut1A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 4ut1 FLAGELLAR
HOOK-ASSOCIATED
PROTEIN
(Burkholderia
pseudomallei) 		5 / 11 ILE A 399
GLY A 386
SER A 383
LEU A 367
SER A 368
 None
 1.34A 3iluB-4ut1A:
undetectable
3iluE-4ut1A:
undetectable		 3iluB-4ut1A:
16.17
3iluE-4ut1A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_A_CAMA423_0
(CYTOCHROME P450)		 4ut1 FLAGELLAR
HOOK-ASSOCIATED
PROTEIN
(Burkholderia
pseudomallei) 		5 / 10 THR A 166
LEU A 278
LEU A 283
GLY A 284
VAL A 159
 EDO  A1639 (-3.2A)
None
None
None
None
 1.28A 3lxiA-4ut1A:
undetectable		 3lxiA-4ut1A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4ut1 FLAGELLAR
HOOK-ASSOCIATED
PROTEIN
(Burkholderia
pseudomallei) 		5 / 11 LEU A 367
SER A 415
ILE A 399
ALA A 388
THR A 389
 None
 1.06A 3mdtB-4ut1A:
undetectable		 3mdtB-4ut1A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4ut1 FLAGELLAR
HOOK-ASSOCIATED
PROTEIN
(Burkholderia
pseudomallei) 		5 / 12 LEU A 287
THR A 244
PRO A 248
SER A 249
LEU A 163
 None
None
EDO  A1641 (-4.2A)
None
None
 1.19A 3nrrA-4ut1A:
undetectable		 3nrrA-4ut1A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4ut1 FLAGELLAR
HOOK-ASSOCIATED
PROTEIN
(Burkholderia
pseudomallei) 		5 / 12 LEU A 287
THR A 244
PRO A 248
SER A 249
LEU A 163
 None
None
EDO  A1641 (-4.2A)
None
None
 1.22A 3nrrB-4ut1A:
undetectable		 3nrrB-4ut1A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_2
(SECRETED ASPARTIC
PROTEASE)		 4ut1 FLAGELLAR
HOOK-ASSOCIATED
PROTEIN
(Burkholderia
pseudomallei) 		4 / 6 PRO A 489
VAL A 542
THR A 493
THR A 492
 None
 1.11A 3tneA-4ut1A:
undetectable		 3tneA-4ut1A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_B_CAMB423_0
(CYTOCHROME P450)		 4ut1 FLAGELLAR
HOOK-ASSOCIATED
PROTEIN
(Burkholderia
pseudomallei) 		5 / 10 THR A 166
LEU A 278
LEU A 283
GLY A 284
VAL A 159
 EDO  A1639 (-3.2A)
None
None
None
None
 1.32A 4c9pB-4ut1A:
undetectable		 4c9pB-4ut1A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4ut1 FLAGELLAR
HOOK-ASSOCIATED
PROTEIN
(Burkholderia
pseudomallei) 		4 / 8 GLY A 319
TYR A 114
LEU A 118
VAL A 121
 None
 0.86A 4fgzB-4ut1A:
undetectable		 4fgzB-4ut1A:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 4ut1 FLAGELLAR
HOOK-ASSOCIATED
PROTEIN
(Burkholderia
pseudomallei) 		3 / 3 PHE A 289
VAL A 159
GLU A 253
 None
 0.83A 4fvqA-4ut1A:
undetectable		 4fvqA-4ut1A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD4_C_AOQC4003_1
(CYTOCHROME B)		 4ut1 FLAGELLAR
HOOK-ASSOCIATED
PROTEIN
(Burkholderia
pseudomallei) 		5 / 12 PHE A 554
GLY A 456
ILE A 458
LEU A 485
ILE A 525
 None
 0.98A 4pd4C-4ut1A:
0.0		 4pd4C-4ut1A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4ut1 FLAGELLAR
HOOK-ASSOCIATED
PROTEIN
(Burkholderia
pseudomallei) 		4 / 4 TYR A 365
THR A 361
GLY A 401
LEU A 404
 None
 1.50A 4w5nA-4ut1A:
undetectable		 4w5nA-4ut1A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 4ut1 FLAGELLAR
HOOK-ASSOCIATED
PROTEIN
(Burkholderia
pseudomallei) 		4 / 8 ALA A 305
ILE A 107
ALA A 110
ILE A 111
 None
EDO  A1642 (-4.3A)
EDO  A1629 ( 4.3A)
None
 0.44A 5mvmA-4ut1A:
4.1
5mvmB-4ut1A:
4.1		 5mvmA-4ut1A:
7.16
5mvmB-4ut1A:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 4ut1 FLAGELLAR
HOOK-ASSOCIATED
PROTEIN
(Burkholderia
pseudomallei) 		3 / 3 SER A 206
LYS A 207
SER A 209
 None
 0.61A 6az3P-4ut1A:
undetectable		 6az3P-4ut1A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 4ut1 FLAGELLAR
HOOK-ASSOCIATED
PROTEIN
(Burkholderia
pseudomallei) 		4 / 6 GLN A  95
LEU A 155
SER A 158
PHE A 289
 None
 1.25A 6ekuA-4ut1A:
undetectable		 6ekuA-4ut1A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4ut1 FLAGELLAR
HOOK-ASSOCIATED
PROTEIN
(Burkholderia
pseudomallei) 		4 / 6 MET A 135
GLY A 117
ALA A 568
LEU A 571
 None
EDO  A1634 (-3.3A)
None
None
 1.09A 6fosA-4ut1A:
2.9		 6fosA-4ut1A:
8.45