SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ut6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3QXV_C_MTXC2000_1 (ANTI-METHOTREXATE CDR1-4 GRAFT VHH)	4ut6	BROADLY NEUTRALIZING HUMAN ANTIBODY EDE2 B7 (Homo sapiens)	5 / 11	VAL H 2 MET H 34 ARG H 71 ASN H 73 VAL H 78	None	0.77A	3qxvC-4ut6H: 18.9	3qxvC-4ut6H: 57.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MJW_A_ACTA603_0 (CHOLINE OXIDASE)	4ut6	BROADLY NEUTRALIZING HUMAN ANTIBODY EDE2 B7 (Homo sapiens)	3 / 3	ARG H 50 HIS H 35 SER H 58	None	0.97A	4mjwA-4ut6H: undetectable 4mjwB-4ut6H: undetectable	4mjwA-4ut6H: 18.99 4mjwB-4ut6H: 18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MJW_B_ACTB603_0 (CHOLINE OXIDASE)	4ut6	BROADLY NEUTRALIZING HUMAN ANTIBODY EDE2 B7 (Homo sapiens)	3 / 3	SER H 58 ARG H 50 HIS H 35	None	0.99A	4mjwA-4ut6H: undetectable 4mjwB-4ut6H: undetectable	4mjwA-4ut6H: 18.99 4mjwB-4ut6H: 18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QWP_B_GCSB307_1 (CHITOSANASE)	4ut6	BROADLY NEUTRALIZING HUMAN ANTIBODY EDE2 B7 (Homo sapiens)	4 / 7	THR H 51 GLY H 54 THR H 57 HIS H 81	None	0.98A	4qwpB-4ut6H: undetectable	4qwpB-4ut6H: 22.18

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3QXV_C_MTXC2000_1","ANTI-METHOTREXATE CDR1-4 GRAFT VHH","4ut6","BROADLY NEUTRALIZING HUMAN ANTIBODY EDE2 B7","Homo sapiens",5,"VAL H   2;MET H  34;ARG H  71;ASN H  73;VAL H  78","None","0.77A","3qxvC-4ut6H:18.9","3qxvC-4ut6H:57.04"],["4MJW_A_ACTA603_0","CHOLINE OXIDASE","4ut6","BROADLY NEUTRALIZING HUMAN ANTIBODY EDE2 B7","Homo sapiens",3,"ARG H  50;HIS H  35;SER H  58","None","0.97A","4mjwA-4ut6H:undetectable;4mjwB-4ut6H:undetectable","4mjwA-4ut6H:18.99;4mjwB-4ut6H:18.99"],["4MJW_B_ACTB603_0","CHOLINE OXIDASE","4ut6","BROADLY NEUTRALIZING HUMAN ANTIBODY EDE2 B7","Homo sapiens",3,"SER H  58;ARG H  50;HIS H  35","None","0.99A","4mjwA-4ut6H:undetectable;4mjwB-4ut6H:undetectable","4mjwA-4ut6H:18.99;4mjwB-4ut6H:18.99"],["4QWP_B_GCSB307_1","CHITOSANASE","4ut6","BROADLY NEUTRALIZING HUMAN ANTIBODY EDE2 B7","Homo sapiens",4,"THR H  51;GLY H  54;THR H  57;HIS H  81","None","0.98A","4qwpB-4ut6H:undetectable","4qwpB-4ut6H:22.18"]]