SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ut7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 4ut7 BROADLY NEUTRALIZING
HUMAN ANTIBODY EDE2
A11
(Homo
sapiens) 		4 / 8 GLY L 100
GLY L  99
TYR L  87
VAL H  48
 None
 0.92A 1dbbH-4ut7L:
15.5
1dbbL-4ut7L:
16.9		 1dbbH-4ut7L:
26.85
1dbbL-4ut7L:
29.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 4ut7 BROADLY NEUTRALIZING
HUMAN ANTIBODY EDE2
A11
(Homo
sapiens) 		5 / 12 ASP L  85
LYS L 103
PRO L   7
GLY L  99
LEU L   4
 None
 1.32A 2nv4A-4ut7L:
undetectable		 2nv4A-4ut7L:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 4ut7 BROADLY NEUTRALIZING
HUMAN ANTIBODY EDE2
A11
BROADLY NEUTRALIZING
HUMAN ANTIBODY EDE2
A11
(Homo
sapiens;
Homo
sapiens) 		4 / 7 TYR H  91
TYR L  36
PRO L  44
TYR L  87
 None
 0.67A 2oldA-4ut7H:
12.6
2oldB-4ut7H:
12.5		 2oldA-4ut7H:
22.94
2oldB-4ut7H:
22.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 4ut7 BROADLY NEUTRALIZING
HUMAN ANTIBODY EDE2
A11
BROADLY NEUTRALIZING
HUMAN ANTIBODY EDE2
A11
(Homo
sapiens;
Homo
sapiens) 		4 / 7 TYR L  36
PRO L  44
TYR L  87
TYR H  91
 None
 0.62A 2oldA-4ut7L:
18.7
2oldB-4ut7L:
18.8		 2oldA-4ut7L:
45.75
2oldB-4ut7L:
45.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 4ut7 BROADLY NEUTRALIZING
HUMAN ANTIBODY EDE2
A11
(Homo
sapiens) 		5 / 9 LEU L 104
THR L 102
VAL L  11
ILE L  19
PHE L  62
 None
 1.06A 3tbgD-4ut7L:
undetectable		 3tbgD-4ut7L:
16.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		 4ut7 BROADLY NEUTRALIZING
HUMAN ANTIBODY EDE2
A11
(Homo
sapiens) 		4 / 7 SER L  34
TYR L  36
TYR L  49
PRO L  55
 None
 0.66A 5aclA-4ut7L:
19.0		 5aclA-4ut7L:
69.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		 4ut7 BROADLY NEUTRALIZING
HUMAN ANTIBODY EDE2
A11
(Homo
sapiens) 		4 / 7 TYR L  36
TYR L  49
GLU L  50
PRO L  55
 None
 0.20A 5aclA-4ut7L:
19.0		 5aclA-4ut7L:
69.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 4ut7 BROADLY NEUTRALIZING
HUMAN ANTIBODY EDE2
A11
(Homo
sapiens) 		5 / 9 VAL L  11
LEU L 104
GLY L  77
LEU L  78
GLN L  17
 None
 1.25A 6czmA-4ut7L:
undetectable
6czmB-4ut7L:
undetectable		 6czmA-4ut7L:
17.99
6czmB-4ut7L:
17.99