SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uu9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB2_0
(ACTINOMYCIN D)		 4uu9 MEDI7814
(Homo
sapiens) 		3 / 3 THR B  95
PRO B  93
THR B  94
 None
 0.78A 1a7yB-4uu9B:
undetectable		 1a7yB-4uu9B:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC2_0
(ACTINOMYCIN D)		 4uu9 MEDI7814
(Homo
sapiens) 		3 / 3 THR B  95
PRO B  93
THR B  94
 None
 0.81A 1dscC-4uu9B:
undetectable		 1dscC-4uu9B:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC8_0
(ACTINOMYCIN D)		 4uu9 MEDI7814
(Homo
sapiens) 		3 / 3 THR B  94
THR B  95
PRO B  93
 None
 0.80A 1dscC-4uu9B:
undetectable		 1dscC-4uu9B:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_C_DVAC8_0
(ACTINOMYCIN D)		 4uu9 MEDI7814
(Homo
sapiens) 		3 / 3 THR B  94
THR B  95
PRO B  93
 None
 0.77A 1fjaC-4uu9B:
undetectable		 1fjaC-4uu9B:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_D_DVAD8_0
(ACTINOMYCIN D)		 4uu9 MEDI7814
(Homo
sapiens) 		3 / 3 THR B  94
THR B  95
PRO B  93
 None
 0.78A 1fjaD-4uu9B:
undetectable		 1fjaD-4uu9B:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_F_DVAF8_0
(ACTINOMYCIN D)		 4uu9 MEDI7814
(Homo
sapiens) 		3 / 3 THR B  94
THR B  95
PRO B  93
 None
 0.84A 1i3wF-4uu9B:
undetectable		 1i3wF-4uu9B:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG8_0
(ACTINOMYCIN D)		 4uu9 MEDI7814
(Homo
sapiens) 		3 / 3 THR B  94
THR B  95
PRO B  93
 None
 0.80A 1i3wG-4uu9B:
undetectable		 1i3wG-4uu9B:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_H_DVAH8_0
(ACTINOMYCIN D)		 4uu9 MEDI7814
(Homo
sapiens) 		3 / 3 THR B  94
THR B  95
PRO B  93
 None
 0.83A 1i3wH-4uu9B:
undetectable		 1i3wH-4uu9B:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD8_0
(ACTINOMYCIN D)		 4uu9 MEDI7814
(Homo
sapiens) 		3 / 3 THR B  94
THR B  95
PRO B  93
 None
 0.83A 1mnvD-4uu9B:
undetectable		 1mnvD-4uu9B:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OVF_B_DVAB2_0
(ACTINOMYCIN D)		 4uu9 MEDI7814
(Homo
sapiens) 		3 / 3 THR B  95
PRO B  93
THR B  94
 None
 0.86A 1ovfB-4uu9B:
undetectable		 1ovfB-4uu9B:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QLT_A_ACTA601_0
(VANILLYL-ALCOHOL
OXIDASE)		 4uu9 MEDI7814
MEDI7814
(Homo
sapiens;
Homo
sapiens) 		4 / 5 TYR B  36
PHE B  98
ILE B  96
TYR A 100
 None
 1.32A 1qltA-4uu9B:
undetectable		 1qltA-4uu9B:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QLT_B_ACTB601_0
(VANILLYL-ALCOHOL
OXIDASE)		 4uu9 MEDI7814
MEDI7814
(Homo
sapiens;
Homo
sapiens) 		4 / 5 TYR B  36
PHE B  98
ILE B  96
TYR A 100
 None
 1.33A 1qltB-4uu9B:
undetectable		 1qltB-4uu9B:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL8_0
(7-AMINO-ACTINOMYCIN
D)		 4uu9 MEDI7814
(Homo
sapiens) 		3 / 3 THR B  94
THR B  95
PRO B  93
 None
 0.86A 1unjL-4uu9B:
undetectable		 1unjL-4uu9B:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR8_0
(7-AMINO-ACTINOMYCIN
D)		 4uu9 MEDI7814
(Homo
sapiens) 		3 / 3 THR B  94
THR B  95
PRO B  93
 None
 0.83A 1unjR-4uu9B:
undetectable		 1unjR-4uu9B:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX2_0
(7-AMINO-ACTINOMYCIN
D)		 4uu9 MEDI7814
(Homo
sapiens) 		3 / 3 THR B  95
PRO B  93
THR B  94
 None
 0.86A 1unjX-4uu9B:
undetectable		 1unjX-4uu9B:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX8_0
(7-AMINO-ACTINOMYCIN
D)		 4uu9 MEDI7814
(Homo
sapiens) 		3 / 3 THR B  94
THR B  95
PRO B  93
 None
 0.86A 1unjX-4uu9B:
undetectable		 1unjX-4uu9B:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE8_0
(7-AMINOACTINOMYCIN D)		 4uu9 MEDI7814
(Homo
sapiens) 		3 / 3 THR B  94
THR B  95
PRO B  93
 None
 0.85A 1unmE-4uu9B:
undetectable		 1unmE-4uu9B:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF2_0
(7-AMINOACTINOMYCIN D)		 4uu9 MEDI7814
(Homo
sapiens) 		3 / 3 THR B  95
PRO B  93
THR B  94
 None
 0.79A 1unmF-4uu9B:
undetectable		 1unmF-4uu9B:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF8_0
(7-AMINOACTINOMYCIN D)		 4uu9 MEDI7814
(Homo
sapiens) 		3 / 3 THR B  94
THR B  95
PRO B  93
 None
 0.78A 1unmF-4uu9B:
undetectable		 1unmF-4uu9B:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAO_A_ACTA601_0
(VANILLYL-ALCOHOL
OXIDASE)		 4uu9 MEDI7814
MEDI7814
(Homo
sapiens;
Homo
sapiens) 		4 / 5 TYR B  36
PHE B  98
ILE B  96
TYR A 100
 None
 1.34A 1vaoA-4uu9B:
undetectable		 1vaoA-4uu9B:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAO_B_ACTB601_0
(VANILLYL-ALCOHOL
OXIDASE)		 4uu9 MEDI7814
MEDI7814
(Homo
sapiens;
Homo
sapiens) 		4 / 5 TYR B  36
PHE B  98
ILE B  96
TYR A 100
 None
 1.34A 1vaoB-4uu9B:
undetectable		 1vaoB-4uu9B:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4uu9 MEDI7814
(Homo
sapiens) 		6 / 11 PHE A  29
ASN A  73
GLY A  54
THR A  57
ILE A  69
LEU A  78
 None
 1.46A 1z11A-4uu9A:
undetectable		 1z11A-4uu9A:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC8_0
(N8-ACTINOMYCIN D)		 4uu9 MEDI7814
(Homo
sapiens) 		3 / 3 THR B  94
THR B  95
PRO B  93
 None
 0.77A 209dC-4uu9B:
undetectable		 209dC-4uu9B:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4uu9 MEDI7814
(Homo
sapiens) 		5 / 12 GLY B 101
GLY B  99
ALA B   3
PRO B   7
VAL B  11
 None
 1.06A 2zulA-4uu9B:
undetectable		 2zulA-4uu9B:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
316D_C_DVAC2_0
(8-FLUORO-ACTINOMYCIN
D)		 4uu9 MEDI7814
(Homo
sapiens) 		3 / 3 THR B  95
PRO B  93
THR B  94
 None
 0.89A 316dC-4uu9B:
undetectable		 316dC-4uu9B:
14.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KDM_H_TESH226_1
(IMMUNOGLOBULIN HEAVY
CHAIN
IMMUNOGLOBULIN LIGHT
CHAIN)		 4uu9 MEDI7814
(Homo
sapiens) 		5 / 9 SER A  35
TRP A  47
ALA A  50
TYR A  58
MET A 100
 None
 0.59A 3kdmH-4uu9A:
22.3
3kdmL-4uu9A:
13.4		 3kdmH-4uu9A:
92.68
3kdmL-4uu9A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 4uu9 MEDI7814
(Homo
sapiens) 		5 / 9 LEU B 104
THR B 102
VAL B  11
ILE B  19
PHE B  62
 None
 1.12A 3tbgD-4uu9B:
undetectable		 3tbgD-4uu9B:
17.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 4uu9 MEDI7814
(Homo
sapiens) 		4 / 8 SER B  30
GLY B  28
ALA B   3
GLY B  25
 None
 0.87A 5albL-4uu9B:
17.1		 5albL-4uu9B:
62.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CJK_B_ACTB302_0
(IMMUNOGLOBULIN FAB
HEAVY CHAIN)		 4uu9 MEDI7814
(Homo
sapiens) 		3 / 3 TYR A  59
GLY A  65
THR A  68
 None
 0.14A 6cjkB-4uu9A:
20.5		 6cjkB-4uu9A:
58.06