SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uuc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 4uuc ANKYRIN REPEAT AND
SOCS BOX PROTEIN 11
(Homo
sapiens) 		5 / 12 LEU A 150
VAL A 149
SER A 143
SER A 141
LEU A  78
 None
 1.17A 1db1A-4uucA:
undetectable		 1db1A-4uucA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_B_117B1_1
(HMG-COA REDUCTASE)		 4uuc ANKYRIN REPEAT AND
SOCS BOX PROTEIN 11
(Homo
sapiens) 		5 / 11 SER A 100
ASN A 137
LEU A 102
ALA A 122
LEU A 118
 None
 1.15A 1hwkA-4uucA:
undetectable		 1hwkA-4uucA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_2
(HMG-COA REDUCTASE)		 4uuc ANKYRIN REPEAT AND
SOCS BOX PROTEIN 11
(Homo
sapiens) 		5 / 11 SER A 100
ASN A 137
LEU A 102
ALA A 122
LEU A 118
 None
 1.13A 1hwkD-4uucA:
undetectable		 1hwkD-4uucA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_1
(HMG-COA REDUCTASE)		 4uuc ANKYRIN REPEAT AND
SOCS BOX PROTEIN 11
(Homo
sapiens) 		5 / 11 SER A 100
ASN A 137
LEU A 102
ALA A 122
LEU A 118
 None
 1.14A 1hwkC-4uucA:
undetectable		 1hwkC-4uucA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RK3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 4uuc ANKYRIN REPEAT AND
SOCS BOX PROTEIN 11
(Homo
sapiens) 		5 / 12 LEU A 150
VAL A 149
SER A 143
SER A 141
LEU A  78
 None
 1.22A 1rk3A-4uucA:
undetectable		 1rk3A-4uucA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 4uuc ANKYRIN REPEAT AND
SOCS BOX PROTEIN 11
(Homo
sapiens) 		5 / 12 LEU A 150
VAL A 149
SER A 143
SER A 141
LEU A  78
 None
 1.17A 1s19A-4uucA:
undetectable		 1s19A-4uucA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)		 4uuc ANKYRIN REPEAT AND
SOCS BOX PROTEIN 11
(Homo
sapiens) 		4 / 6 LEU A 107
GLU A 169
ALA A 132
THR A 128
 None
 1.01A 2roxB-4uucA:
undetectable		 2roxB-4uucA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 4uuc ANKYRIN REPEAT AND
SOCS BOX PROTEIN 11
(Homo
sapiens) 		5 / 11 HIS A 103
ALA A  73
CYH A 106
GLY A 108
VAL A 149
 None
 1.18A 2uxpB-4uucA:
undetectable		 2uxpB-4uucA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 4uuc ANKYRIN REPEAT AND
SOCS BOX PROTEIN 11
(Homo
sapiens) 		5 / 12 LEU A 150
VAL A 149
SER A 143
SER A 141
LEU A  78
 None
 1.25A 2zlcA-4uucA:
undetectable		 2zlcA-4uucA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)		 4uuc ANKYRIN REPEAT AND
SOCS BOX PROTEIN 11
(Homo
sapiens) 		5 / 12 LEU A 150
VAL A 149
SER A 143
SER A 141
LEU A  78
 None
 1.20A 3m7rA-4uucA:
undetectable		 3m7rA-4uucA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 4uuc ANKYRIN REPEAT AND
SOCS BOX PROTEIN 11
(Homo
sapiens) 		5 / 12 LEU A 150
VAL A 149
SER A 143
SER A 141
LEU A  78
 None
 1.21A 3vt3A-4uucA:
undetectable		 3vt3A-4uucA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 4uuc ANKYRIN REPEAT AND
SOCS BOX PROTEIN 11
(Homo
sapiens) 		5 / 12 LEU A 150
VAL A 149
SER A 143
SER A 141
LEU A  78
 None
 1.17A 3vt7A-4uucA:
undetectable		 3vt7A-4uucA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 4uuc ANKYRIN REPEAT AND
SOCS BOX PROTEIN 11
(Homo
sapiens) 		4 / 8 THR A 230
PRO A 231
VAL A 222
SER A 221
 None
 0.54A 4qknA-4uucA:
undetectable		 4qknA-4uucA:
18.97