SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uug'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4uug AMINE TRANSAMINASE
(Aspergillus
fumigatus) 		5 / 10 ARG A 196
ALA A 160
GLY A 213
THR A 163
ILE A 218
 None
 1.20A 1gtnB-4uugA:
undetectable
1gtnC-4uugA:
undetectable		 1gtnB-4uugA:
12.62
1gtnC-4uugA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4uug AMINE TRANSAMINASE
(Aspergillus
fumigatus) 		5 / 10 ARG A 196
ALA A 160
GLY A 213
THR A 163
ILE A 218
 None
 1.19A 1gtnH-4uugA:
undetectable
1gtnI-4uugA:
undetectable		 1gtnH-4uugA:
12.62
1gtnI-4uugA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4uug AMINE TRANSAMINASE
(Aspergillus
fumigatus) 		4 / 7 ILE A  78
LEU A  93
ILE A  61
ASP A  59
 None
 0.93A 1yc2E-4uugA:
undetectable		 1yc2E-4uugA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4uug AMINE TRANSAMINASE
(Aspergillus
fumigatus) 		5 / 12 THR A  57
GLY A  50
ILE A 178
GLN A 182
PHE A 174
 None
 1.43A 2akeA-4uugA:
undetectable		 2akeA-4uugA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4uug AMINE TRANSAMINASE
(Aspergillus
fumigatus) 		3 / 3 ASP A  55
ASP A  48
ASN A 180
 None
 0.81A 2bm9D-4uugA:
undetectable		 2bm9D-4uugA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4uug AMINE TRANSAMINASE
(Aspergillus
fumigatus) 		4 / 8 ILE A 138
LEU A  91
PHE A  89
LEU A 100
 None
 0.86A 3ablN-4uugA:
undetectable
3ablW-4uugA:
undetectable		 3ablN-4uugA:
21.28
3ablW-4uugA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 4uug AMINE TRANSAMINASE
(Aspergillus
fumigatus) 		5 / 12 LEU A 203
PHE A 174
GLN A 182
ILE A 117
MET A  85
 None
None
None
None
FMT  A 405 (-4.7A)
 1.01A 3gwxB-4uugA:
undetectable		 3gwxB-4uugA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNE_A_DEXA784_2
(GLUCOCORTICOID
RECEPTOR)		 4uug AMINE TRANSAMINASE
(Aspergillus
fumigatus) 		4 / 4 LEU A 210
MET A 271
GLN A 262
TYR A 227
 None
 1.35A 3mneA-4uugA:
0.0		 3mneA-4uugA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_2
(GLUCOCORTICOID
RECEPTOR)		 4uug AMINE TRANSAMINASE
(Aspergillus
fumigatus) 		4 / 6 LEU A 210
MET A 271
GLN A 262
TYR A 227
 None
 1.37A 3mnoA-4uugA:
undetectable		 3mnoA-4uugA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_2
(GLUCOCORTICOID
RECEPTOR)		 4uug AMINE TRANSAMINASE
(Aspergillus
fumigatus) 		4 / 6 LEU A 210
MET A 271
GLN A 262
TYR A 227
 None
 1.37A 3mnpA-4uugA:
undetectable		 3mnpA-4uugA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_1
(HIV-1 PROTEASE)		 4uug AMINE TRANSAMINASE
(Aspergillus
fumigatus) 		4 / 7 ASP A  48
GLY A 121
ASP A  55
ILE A 138
 None
 0.78A 3t3cA-4uugA:
undetectable		 3t3cA-4uugA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_D_CLMD221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4uug AMINE TRANSAMINASE
(Aspergillus
fumigatus) 		5 / 12 THR A 238
SER A 241
VAL A 245
ALA A   2
HIS A 309
 PXG  A 401 (-3.5A)
None
None
None
FMT  A 403 (-3.8A)
 1.46A 3u9fD-4uugA:
undetectable
3u9fE-4uugA:
undetectable		 3u9fD-4uugA:
18.79
3u9fE-4uugA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_G_CLMG221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4uug AMINE TRANSAMINASE
(Aspergillus
fumigatus) 		5 / 12 THR A 238
SER A 241
VAL A 245
ALA A   2
HIS A 309
 PXG  A 401 (-3.5A)
None
None
None
FMT  A 403 (-3.8A)
 1.42A 3u9fG-4uugA:
undetectable
3u9fH-4uugA:
undetectable		 3u9fG-4uugA:
18.79
3u9fH-4uugA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 4uug AMINE TRANSAMINASE
(Aspergillus
fumigatus) 		4 / 8 VAL A 221
VAL A 219
ILE A 278
ILE A 301
 None
 0.74A 3warA-4uugA:
undetectable		 3warA-4uugA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4uug AMINE TRANSAMINASE
(Aspergillus
fumigatus) 		5 / 12 GLY A 213
GLY A 215
LEU A 210
ILE A 269
LEU A 284
 None
PXG  A 401 (-3.3A)
None
None
None
 0.98A 4n49A-4uugA:
undetectable		 4n49A-4uugA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)		 4uug AMINE TRANSAMINASE
(Aspergillus
fumigatus) 		4 / 6 ARG A  14
ALA A  13
ASP A 111
LYS A   6
 None
 0.78A 4ot2A-4uugA:
undetectable		 4ot2A-4uugA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4uug AMINE TRANSAMINASE
(Aspergillus
fumigatus) 		4 / 5 GLY A 189
SER A 214
GLU A 192
ASP A 185
 None
 1.36A 4xueA-4uugA:
undetectable		 4xueA-4uugA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4uug AMINE TRANSAMINASE
(Aspergillus
fumigatus) 		5 / 12 ARG A 196
ALA A 160
GLY A 213
THR A 163
ILE A 218
 None
 1.15A 5eeuI-4uugA:
undetectable
5eeuJ-4uugA:
undetectable		 5eeuI-4uugA:
12.62
5eeuJ-4uugA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4uug AMINE TRANSAMINASE
(Aspergillus
fumigatus) 		5 / 12 ARG A 196
ALA A 160
GLY A 213
THR A 163
ILE A 218
 None
 1.15A 5eevI-4uugA:
undetectable
5eevJ-4uugA:
undetectable		 5eevI-4uugA:
12.62
5eevJ-4uugA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4uug AMINE TRANSAMINASE
(Aspergillus
fumigatus) 		5 / 12 ARG A 196
ALA A 160
GLY A 213
THR A 163
ILE A 218
 None
 1.15A 5eewI-4uugA:
undetectable
5eewJ-4uugA:
undetectable		 5eewI-4uugA:
12.62
5eewJ-4uugA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 4uug AMINE TRANSAMINASE
(Aspergillus
fumigatus) 		3 / 3 LYS A  88
ASP A  83
ILE A 138
 None
 0.88A 5kc4E-4uugA:
undetectable		 5kc4E-4uugA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MTH_A_ACTA301_0
(ANTIBODY FAB HEAVY
CHAIN)		 4uug AMINE TRANSAMINASE
(Aspergillus
fumigatus) 		4 / 4 THR A 204
VAL A 166
PRO A 201
THR A 163
 None
 1.41A 5mthA-4uugA:
undetectable
5mthH-4uugA:
undetectable		 5mthA-4uugA:
21.65
5mthH-4uugA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4uug AMINE TRANSAMINASE
(Aspergillus
fumigatus) 		3 / 3 SER A  62
HIS A 309
TYR A 305
 FMT  A 403 (-2.5A)
FMT  A 403 (-3.8A)
FMT  A 403 (-4.3A)
 0.85A 5y2tA-4uugA:
undetectable		 5y2tA-4uugA:
undetectable