SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uul'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 4uul L-LACTATE
DEHYDROGENASE
(Trichomonas
vaginalis) 		4 / 5 HIS A 235
GLU A 234
ALA A 229
SER A 240
 None
 1.29A 1errA-4uulA:
undetectable
1errB-4uulA:
undetectable		 1errA-4uulA:
21.45
1errB-4uulA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 4uul L-LACTATE
DEHYDROGENASE
(Trichomonas
vaginalis) 		5 / 12 GLY A 184
ASN A 185
SER A  88
GLY A 187
VAL A 191
 None
 1.14A 1ffyA-4uulA:
undetectable		 1ffyA-4uulA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 4uul L-LACTATE
DEHYDROGENASE
(Trichomonas
vaginalis) 		4 / 8 SER A 168
ILE A 225
PHE A 221
VAL A 208
 None
 1.17A 1kb9A-4uulA:
undetectable
1kb9C-4uulA:
undetectable
1kb9D-4uulA:
undetectable
1kb9E-4uulA:
undetectable		 1kb9A-4uulA:
23.03
1kb9C-4uulA:
18.75
1kb9D-4uulA:
20.33
1kb9E-4uulA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QW6_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4uul L-LACTATE
DEHYDROGENASE
(Trichomonas
vaginalis) 		3 / 3 ARG A 310
VAL A 191
TRP A 183
 None
 1.13A 1qw6A-4uulA:
undetectable		 1qw6A-4uulA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QWC_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4uul L-LACTATE
DEHYDROGENASE
(Trichomonas
vaginalis) 		3 / 3 ARG A 310
VAL A 191
TRP A 183
 None
 1.16A 1qwcA-4uulA:
undetectable		 1qwcA-4uulA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAG_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4uul L-LACTATE
DEHYDROGENASE
(Trichomonas
vaginalis) 		3 / 3 ARG A 310
VAL A 191
TRP A 183
 None
 1.11A 1vagA-4uulA:
undetectable		 1vagA-4uulA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVI_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4uul L-LACTATE
DEHYDROGENASE
(Trichomonas
vaginalis) 		3 / 3 ARG A 310
VAL A 191
TRP A 183
 None
 1.11A 1zviA-4uulA:
undetectable		 1zviA-4uulA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4uul L-LACTATE
DEHYDROGENASE
(Trichomonas
vaginalis) 		5 / 12 GLY A  11
SER A  21
ASP A  41
ARG A  48
ALA A  87
 None
 1.14A 2br4D-4uulA:
4.7		 2br4D-4uulA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O0M_A_ACTA146_0
(HIT FAMILY PROTEIN)		 4uul L-LACTATE
DEHYDROGENASE
(Trichomonas
vaginalis) 		4 / 4 ASP A 319
GLU A 188
GLU A 323
ARG A  97
 None
 1.38A 3o0mA-4uulA:
undetectable		 3o0mA-4uulA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4uul L-LACTATE
DEHYDROGENASE
(Trichomonas
vaginalis) 		5 / 9 ALA A  13
GLY A  17
LEU A  56
LEU A  39
LEU A  20
 None
 1.16A 3wdmC-4uulA:
4.2		 3wdmC-4uulA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)		 4uul L-LACTATE
DEHYDROGENASE
(Trichomonas
vaginalis) 		3 / 3 LYS A 120
PRO A 121
SER A 122
 None
 0.31A 4k50I-4uulA:
undetectable		 4k50I-4uulA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4uul L-LACTATE
DEHYDROGENASE
(Trichomonas
vaginalis) 		4 / 6 VAL A   7
LEU A  37
LEU A  20
PHE A 108
 None
 1.04A 4o1zA-4uulA:
undetectable		 4o1zA-4uulA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA205_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4uul L-LACTATE
DEHYDROGENASE
(Trichomonas
vaginalis) 		5 / 12 PHE A 151
PRO A 270
MET A 140
ALA A 327
LEU A 331
 None
 1.36A 4oadA-4uulA:
undetectable		 4oadA-4uulA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 4uul L-LACTATE
DEHYDROGENASE
(Trichomonas
vaginalis) 		5 / 12 ILE A   9
GLY A  17
ALA A 241
HIS A  22
ILE A  24
 None
 1.09A 4rvdA-4uulA:
4.5		 4rvdA-4uulA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 4uul L-LACTATE
DEHYDROGENASE
(Trichomonas
vaginalis) 		5 / 12 ILE A   9
GLY A  17
ALA A 241
HIS A  22
ILE A  24
 None
 1.08A 4rvgA-4uulA:
4.5		 4rvgA-4uulA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4uul L-LACTATE
DEHYDROGENASE
(Trichomonas
vaginalis) 		3 / 3 ARG A 310
VAL A 191
TRP A 183
 None
 1.15A 5fvoA-4uulA:
undetectable		 5fvoA-4uulA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 4uul L-LACTATE
DEHYDROGENASE
(Trichomonas
vaginalis) 		3 / 3 ARG A  97
ASN A 185
ASP A 158
 None
 0.66A 5gwxA-4uulA:
6.7		 5gwxA-4uulA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4uul L-LACTATE
DEHYDROGENASE
(Trichomonas
vaginalis) 		5 / 12 GLU A 323
LEU A 331
ALA A 327
THR A 111
PRO A 131
 None
 1.21A 5nd3B-4uulA:
5.6		 5nd3B-4uulA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_D_CCSD14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 4uul L-LACTATE
DEHYDROGENASE
(Trichomonas
vaginalis) 		5 / 12 PHE A  84
LEU A   8
SER A  21
GLY A  11
VAL A  86
 None
 1.16A 5o4yD-4uulA:
undetectable
5o4yE-4uulA:
undetectable		 5o4yD-4uulA:
3.38
5o4yE-4uulA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4uul L-LACTATE
DEHYDROGENASE
(Trichomonas
vaginalis) 		5 / 12 ALA A   4
GLN A  34
ILE A  24
ALA A  65
LEU A 256
 None
 1.00A 6a5zD-4uulA:
undetectable		 6a5zD-4uulA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 4uul L-LACTATE
DEHYDROGENASE
(Trichomonas
vaginalis) 		4 / 5 PHE A 285
VAL A 264
PRO A 276
VAL A 271
 None
 1.20A 6ekzA-4uulA:
undetectable		 6ekzA-4uulA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 4uul L-LACTATE
DEHYDROGENASE
(Trichomonas
vaginalis) 		3 / 3 TRP A 230
ILE A 232
ASP A 231
 None
 0.72A 6i0y7-4uulA:
undetectable		 6i0y7-4uulA:
8.20