SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uuo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_C_DVAC6_0
(GRAMICIDIN A)		 4uuo CYTOSOLIC MALATE
DEHYDROGENASE
(Trichomonas
vaginalis) 		3 / 3 ALA A 152
VAL A 124
TRP A 150
 None
 0.73A 1av2C-4uuoA:
undetectable
1av2D-4uuoA:
undetectable		 1av2C-4uuoA:
6.80
1av2D-4uuoA:
6.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_A_MTXA732_1
(THYMIDYLATE SYNTHASE)		 4uuo CYTOSOLIC MALATE
DEHYDROGENASE
(Trichomonas
vaginalis) 		5 / 12 ILE A 106
GLY A 111
PHE A 107
TYR A 117
VAL A  72
 None
 1.09A 1axwA-4uuoA:
undetectable		 1axwA-4uuoA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)		 4uuo CYTOSOLIC MALATE
DEHYDROGENASE
(Trichomonas
vaginalis) 		4 / 5 GLY A  16
LEU A  19
THR A  20
VAL A  85
 None
 1.04A 1ekjF-4uuoA:
2.5
1ekjG-4uuoA:
undetectable		 1ekjF-4uuoA:
22.57
1ekjG-4uuoA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 4uuo CYTOSOLIC MALATE
DEHYDROGENASE
(Trichomonas
vaginalis) 		5 / 10 ALA A 138
ILE A 106
GLY A 105
GLY A 104
PRO A 130
 None
 0.92A 1sdvA-4uuoA:
undetectable		 1sdvA-4uuoA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_C_T44C601_1
(TRANSTHYRETIN)		 4uuo CYTOSOLIC MALATE
DEHYDROGENASE
(Trichomonas
vaginalis) 		5 / 9 LEU A 332
ALA A 140
LYS A 323
LEU A 136
ALA A 326
 None
 1.33A 1sn0A-4uuoA:
undetectable
1sn0C-4uuoA:
undetectable		 1sn0A-4uuoA:
17.16
1sn0C-4uuoA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_C_T44C601_1
(TRANSTHYRETIN)		 4uuo CYTOSOLIC MALATE
DEHYDROGENASE
(Trichomonas
vaginalis) 		5 / 9 LYS A 323
LEU A 136
ALA A 326
LEU A 332
ALA A 140
 None
 1.32A 1sn0A-4uuoA:
undetectable
1sn0C-4uuoA:
undetectable		 1sn0A-4uuoA:
17.16
1sn0C-4uuoA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOF_A_PNNA1312_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 4uuo CYTOSOLIC MALATE
DEHYDROGENASE
(Trichomonas
vaginalis) 		5 / 11 PHE A 220
ASP A 199
THR A 204
HIS A 177
VAL A 179
 None
 1.38A 1uofA-4uuoA:
undetectable		 1uofA-4uuoA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_C_DVAC6_0
(GRAMICIDIN D)		 4uuo CYTOSOLIC MALATE
DEHYDROGENASE
(Trichomonas
vaginalis) 		3 / 3 ALA A 152
VAL A 124
TRP A 150
 None
 0.66A 1w5uC-4uuoA:
undetectable
1w5uD-4uuoA:
undetectable		 1w5uC-4uuoA:
6.80
1w5uD-4uuoA:
6.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 4uuo CYTOSOLIC MALATE
DEHYDROGENASE
(Trichomonas
vaginalis) 		5 / 11 GLY A  16
GLY A  13
SER A 238
ALA A 243
ARG A 235
 None
 0.91A 1x7pA-4uuoA:
2.3
1x7pB-4uuoA:
2.5		 1x7pA-4uuoA:
22.00
1x7pB-4uuoA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA702_0
(FERROCHELATASE)		 4uuo CYTOSOLIC MALATE
DEHYDROGENASE
(Trichomonas
vaginalis) 		4 / 7 ARG A  22
LEU A  19
VAL A 251
TRP A 254
 None
 1.36A 2hrcA-4uuoA:
1.9		 2hrcA-4uuoA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_B_DVAB6_0
(GRAMICIDIN D)		 4uuo CYTOSOLIC MALATE
DEHYDROGENASE
(Trichomonas
vaginalis) 		3 / 3 TRP A 150
ALA A 152
VAL A 124
 None
 0.76A 2izqA-4uuoA:
undetectable
2izqB-4uuoA:
undetectable		 2izqA-4uuoA:
6.80
2izqB-4uuoA:
6.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4uuo CYTOSOLIC MALATE
DEHYDROGENASE
(Trichomonas
vaginalis) 		4 / 5 GLU A 274
PRO A 275
ILE A 278
GLY A 277
 None
 0.84A 2qeuA-4uuoA:
undetectable
2qeuC-4uuoA:
undetectable		 2qeuA-4uuoA:
19.30
2qeuC-4uuoA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 4uuo CYTOSOLIC MALATE
DEHYDROGENASE
(Trichomonas
vaginalis) 		5 / 10 PHE A 107
SER A 285
LEU A   7
ILE A 181
GLY A 128
 None
 1.12A 2v0mA-4uuoA:
undetectable		 2v0mA-4uuoA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 4uuo CYTOSOLIC MALATE
DEHYDROGENASE
(Trichomonas
vaginalis) 		4 / 5 GLN A 189
ALA A 225
GLN A 222
ILE A 224
 None
 1.48A 2z0aA-4uuoA:
undetectable		 2z0aA-4uuoA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		 4uuo CYTOSOLIC MALATE
DEHYDROGENASE
(Trichomonas
vaginalis) 		4 / 7 ILE A 106
GLN A 110
GLY A 105
LEU A 330
 None
 0.77A 3bjwB-4uuoA:
undetectable		 3bjwB-4uuoA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		 4uuo CYTOSOLIC MALATE
DEHYDROGENASE
(Trichomonas
vaginalis) 		4 / 7 VAL A  85
ILE A 106
GLY A 105
LEU A 330
 None
 0.69A 3bjwB-4uuoA:
undetectable		 3bjwB-4uuoA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_2
(PHOSPHOLIPASE A2)		 4uuo CYTOSOLIC MALATE
DEHYDROGENASE
(Trichomonas
vaginalis) 		4 / 6 VAL A  85
GLN A 110
GLY A 105
LEU A 330
 None
 1.00A 3bjwE-4uuoA:
undetectable		 3bjwE-4uuoA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_3
(PHOSPHOLIPASE A2)		 4uuo CYTOSOLIC MALATE
DEHYDROGENASE
(Trichomonas
vaginalis) 		5 / 7 VAL A  85
ILE A 106
GLN A 110
GLY A 105
LEU A 330
 None
 0.85A 3bjwF-4uuoA:
undetectable		 3bjwF-4uuoA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 4uuo CYTOSOLIC MALATE
DEHYDROGENASE
(Trichomonas
vaginalis) 		5 / 7 VAL A  85
ILE A 106
GLN A 110
GLY A 105
LEU A 330
 None
 0.90A 3bjwH-4uuoA:
undetectable		 3bjwH-4uuoA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)		 4uuo CYTOSOLIC MALATE
DEHYDROGENASE
(Trichomonas
vaginalis) 		5 / 11 GLY A  10
GLY A  13
GLU A  40
ILE A  41
ILE A 106
 None
 0.68A 3grvA-4uuoA:
4.1		 3grvA-4uuoA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4uuo CYTOSOLIC MALATE
DEHYDROGENASE
(Trichomonas
vaginalis) 		3 / 3 ARG A 160
THR A 194
THR A 315
 None
 0.80A 3k2hB-4uuoA:
undetectable		 3k2hB-4uuoA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_A_DVAA6_0
(GRAMICIDIN D)		 4uuo CYTOSOLIC MALATE
DEHYDROGENASE
(Trichomonas
vaginalis) 		3 / 3 ALA A 152
VAL A 124
TRP A 150
 None
 0.77A 3l8lA-4uuoA:
undetectable
3l8lB-4uuoA:
undetectable		 3l8lA-4uuoA:
6.80
3l8lB-4uuoA:
6.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_C_DVAC6_0
(GRAMICIDIN D)		 4uuo CYTOSOLIC MALATE
DEHYDROGENASE
(Trichomonas
vaginalis) 		3 / 3 ALA A 152
VAL A 124
TRP A 150
 None
 0.56A 3l8lC-4uuoA:
undetectable
3l8lD-4uuoA:
undetectable		 3l8lC-4uuoA:
6.80
3l8lD-4uuoA:
6.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 4uuo CYTOSOLIC MALATE
DEHYDROGENASE
(Trichomonas
vaginalis) 		5 / 12 ILE A 106
GLY A 111
PHE A 107
TYR A 117
VAL A  72
 None
 1.10A 4foxD-4uuoA:
undetectable		 4foxD-4uuoA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_D_BRLD501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4uuo CYTOSOLIC MALATE
DEHYDROGENASE
(Trichomonas
vaginalis) 		5 / 12 PHE A  83
GLY A  16
LEU A 156
MET A 153
LEU A  28
 None
 1.36A 5ji0D-4uuoA:
undetectable		 5ji0D-4uuoA:
20.60