SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uup'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		 4uup MALATE DEHYDROGENASE
(synthetic
construct) 		5 / 11 ALA A 153
LEU A 126
HIS A 186
ARG A 161
ALA A 244
 None
None
NAI  A 345 ( 3.5A)
PO4  A 346 (-3.9A)
NAI  A 345 ( 2.8A)
 1.14A 1h9zA-4uupA:
undetectable		 1h9zA-4uupA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 4uup MALATE DEHYDROGENASE
(synthetic
construct) 		5 / 10 GLU A 323
ALA A 327
LEU A 101
ALA A 105
PHE A 108
 None
 1.25A 1mjqG-4uupA:
undetectable
1mjqH-4uupA:
undetectable		 1mjqG-4uupA:
16.00
1mjqH-4uupA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 4uup MALATE DEHYDROGENASE
(synthetic
construct) 		5 / 10 GLU A 323
ALA A 327
LEU A 101
PHE A 108
GLY A 106
 None
 1.25A 1mjqG-4uupA:
undetectable
1mjqH-4uupA:
undetectable		 1mjqG-4uupA:
16.00
1mjqH-4uupA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4uup MALATE DEHYDROGENASE
(synthetic
construct) 		4 / 7 ALA A 105
ARG A  97
ASN A 135
GLU A 323
 None
PO4  A 346 (-3.5A)
None
None
 1.15A 1t9wA-4uupA:
undetectable		 1t9wA-4uupA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 4uup MALATE DEHYDROGENASE
(synthetic
construct) 		4 / 6 LEU A 137
THR A 134
PHE A 328
LEU A 331
 None
 1.08A 2wm3A-4uupA:
4.9		 2wm3A-4uupA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4uup MALATE DEHYDROGENASE
(synthetic
construct) 		3 / 3 VAL A 309
LYS A 312
HIS A 159
 None
 0.65A 3elzA-4uupA:
undetectable		 3elzA-4uupA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)		 4uup MALATE DEHYDROGENASE
(synthetic
construct) 		5 / 11 GLY A  11
GLY A  14
GLU A  41
ILE A  42
ILE A 107
 NAI  A 345 (-2.9A)
NAI  A 345 (-3.3A)
NAI  A 345 (-2.3A)
NAI  A 345 (-4.2A)
NAI  A 345 (-3.5A)
 0.62A 3grvA-4uupA:
5.6		 3grvA-4uupA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4uup MALATE DEHYDROGENASE
(synthetic
construct) 		3 / 3 ALA A 245
ARG A  23
LYS A  26
 None
 1.05A 3kp3B-4uupA:
undetectable		 3kp3B-4uupA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KZ7_A_RAPA225_1
(FK506-BINDING
PROTEIN 3)		 4uup MALATE DEHYDROGENASE
(synthetic
construct) 		5 / 10 TYR A 277
LEU A 303
VAL A 181
TRP A 183
ILE A 269
 None
 1.26A 3kz7A-4uupA:
undetectable		 3kz7A-4uupA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4uup MALATE DEHYDROGENASE
(synthetic
construct) 		5 / 9 ALA A  13
GLY A  17
LEU A  56
LEU A  39
LEU A  20
 NAI  A 345 ( 4.2A)
None
None
None
None
 1.18A 3wdmC-4uupA:
3.9		 3wdmC-4uupA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 4uup MALATE DEHYDROGENASE
(synthetic
construct) 		3 / 3 ARG A 161
GLU A 165
PHE A 221
 PO4  A 346 (-3.9A)
None
None
 1.01A 4kszA-4uupA:
undetectable		 4kszA-4uupA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4uup MALATE DEHYDROGENASE
(synthetic
construct) 		4 / 6 VAL A   7
LEU A  37
LEU A  20
PHE A 108
 None
 0.91A 4o1zA-4uupA:
undetectable		 4o1zA-4uupA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_B_ESTB601_1
(ESTROGEN RECEPTOR)		 4uup MALATE DEHYDROGENASE
(synthetic
construct) 		5 / 11 ALA A 247
LEU A  29
ARG A 253
ILE A   9
GLY A  17
 OCS  A 250 (-4.4A)
None
OCS  A 250 (-3.4A)
None
None
 1.12A 5dxbB-4uupA:
undetectable		 5dxbB-4uupA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 4uup MALATE DEHYDROGENASE
(synthetic
construct) 		5 / 12 ILE A 107
SER A  88
VAL A  52
CYH A  53
LEU A  39
 NAI  A 345 (-3.5A)
NAI  A 345 (-4.3A)
None
None
None
 1.12A 5ergB-4uupA:
6.5		 5ergB-4uupA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)		 4uup MALATE DEHYDROGENASE
(synthetic
construct) 		5 / 12 ALA A 248
GLY A  11
ALA A  12
LEU A  56
LEU A  37
 None
NAI  A 345 (-2.9A)
None
None
None
 1.47A 5x23A-4uupA:
undetectable		 5x23A-4uupA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 4uup MALATE DEHYDROGENASE
(synthetic
construct) 		5 / 12 ASP A  81
VAL A  68
GLY A  66
ALA A  65
GLU A  74
 None
 1.20A 6bqgA-4uupA:
undetectable		 6bqgA-4uupA:
14.33