SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uuu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_A_SAMA603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4uuu CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		7 / 7 PHE A 443
ASP A 444
GLN A 445
PRO A 447
THR A 535
ILE A 537
ASP A 538
 SAM  A1546 (-3.5A)
SAM  A1546 ( 3.2A)
SAM  A1546 (-3.0A)
None
SAM  A1546 (-2.9A)
None
SAM  A1546 ( 2.9A)
 0.36A 4pcuA-4uuuA:
3.0		 4pcuA-4uuuA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_B_SAMB603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4uuu CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		7 / 9 LEU A 423
PHE A 443
ASP A 444
VAL A 533
THR A 535
ILE A 537
ASP A 538
 SAM  A1546 (-4.5A)
SAM  A1546 (-3.5A)
SAM  A1546 ( 3.2A)
SAM  A1546 (-4.5A)
SAM  A1546 (-2.9A)
None
SAM  A1546 ( 2.9A)
 0.64A 4pcuA-4uuuA:
3.0
4pcuB-4uuuA:
19.3		 4pcuA-4uuuA:
27.93
4pcuB-4uuuA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_B_SAMB603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4uuu CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		7 / 9 PHE A 443
ASP A 444
GLN A 445
VAL A 533
THR A 535
ILE A 537
ASP A 538
 SAM  A1546 (-3.5A)
SAM  A1546 ( 3.2A)
SAM  A1546 (-3.0A)
SAM  A1546 (-4.5A)
SAM  A1546 (-2.9A)
None
SAM  A1546 ( 2.9A)
 0.68A 4pcuA-4uuuA:
3.0
4pcuB-4uuuA:
19.3		 4pcuA-4uuuA:
27.93
4pcuB-4uuuA:
27.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UUU_A_SAMA1546_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4uuu CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		9 / 11 LEU A 423
PHE A 443
ASP A 444
GLN A 445
ALA A 446
VAL A 533
THR A 535
ILE A 537
ASP A 538
 SAM  A1546 (-4.5A)
SAM  A1546 (-3.5A)
SAM  A1546 ( 3.2A)
SAM  A1546 (-3.0A)
SAM  A1546 ( 3.7A)
SAM  A1546 (-4.5A)
SAM  A1546 (-2.9A)
None
SAM  A1546 ( 2.9A)
 0.00A 4uuuA-4uuuA:
26.6
4uuuB-4uuuA:
21.4		 4uuuA-4uuuA:
100.00
4uuuB-4uuuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UUU_B_SAMB1548_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4uuu CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		10 / 11 LEU A 423
PHE A 443
ASP A 444
GLN A 445
ALA A 446
PRO A 447
VAL A 533
THR A 535
ILE A 537
ASP A 538
 SAM  A1546 (-4.5A)
SAM  A1546 (-3.5A)
SAM  A1546 ( 3.2A)
SAM  A1546 (-3.0A)
SAM  A1546 ( 3.7A)
None
SAM  A1546 (-4.5A)
SAM  A1546 (-2.9A)
None
SAM  A1546 ( 2.9A)
 0.15A 4uuuB-4uuuA:
21.4		 4uuuB-4uuuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UUU_B_SAMB1548_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4uuu CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		7 / 11 SER A 420
LEU A 423
ALA A 446
PRO A 447
VAL A 533
ILE A 537
ASP A 538
 EDO  A1547 (-2.7A)
SAM  A1546 (-4.5A)
SAM  A1546 ( 3.7A)
None
SAM  A1546 (-4.5A)
None
SAM  A1546 ( 2.9A)
 0.72A 4uuuB-4uuuA:
21.4		 4uuuB-4uuuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4uuu CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		4 / 6 PRO A 422
ILE A 455
VAL A 459
PHE A 487
 SAM  A1546 (-4.7A)
None
None
None
 1.04A 4xe5A-4uuuA:
undetectable		 4xe5A-4uuuA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 4uuu CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		4 / 6 PRO A 407
LEU A 540
PHE A 542
LEU A 499
 None
None
EDO  A1551 (-3.7A)
None
 1.11A 5tl8A-4uuuA:
undetectable		 5tl8A-4uuuA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 4uuu CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		5 / 10 ALA A 446
VAL A 459
LEU A 510
VAL A 449
ILE A 455
 SAM  A1546 ( 3.7A)
None
None
None
None
 1.11A 5v02B-4uuuA:
undetectable
5v02R-4uuuA:
undetectable		 5v02B-4uuuA:
19.50
5v02R-4uuuA:
20.96