SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uuy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4uuy VACUOLAR MEMBRANE
PROTEIN PEP3
(Saccharomyces
cerevisiae) 		4 / 8 TRP A 171
LEU A 239
TYR A 141
THR A 163
 None
 1.44A 1uw6P-4uuyA:
undetectable
1uw6T-4uuyA:
undetectable		 1uw6P-4uuyA:
19.25
1uw6T-4uuyA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		 4uuy VACUOLAR MEMBRANE
PROTEIN PEP3
(Saccharomyces
cerevisiae) 		5 / 12 ASN A  81
GLY A  83
MET A  86
MET A  65
ILE A  64
 None
 1.43A 3h52A-4uuyA:
undetectable		 3h52A-4uuyA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS4_A_AZMA702_1
(CARBONIC ANHYDRASE 2)		 4uuy VACUOLAR MEMBRANE
PROTEIN PEP3
(Saccharomyces
cerevisiae) 		4 / 7 VAL A  75
LYS A  89
TRP A 109
GLU A 129
 None
None
SO4  A1003 (-4.2A)
None
 0.96A 3hs4A-4uuyA:
undetectable		 3hs4A-4uuyA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 4uuy VACUOLAR MEMBRANE
PROTEIN PEP3
(Saccharomyces
cerevisiae) 		5 / 10 THR A 137
PHE A 115
GLU A 129
LEU A  96
ILE A  99
 None
 1.22A 3kvrA-4uuyA:
undetectable		 3kvrA-4uuyA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 4uuy VACUOLAR MEMBRANE
PROTEIN PEP3
(Saccharomyces
cerevisiae) 		5 / 10 THR A 137
PHE A 115
GLU A 129
LEU A  96
ILE A  99
 None
 1.20A 3kvrB-4uuyA:
undetectable		 3kvrB-4uuyA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OI8_A_ADNA2_1
(UNCHARACTERIZED
PROTEIN)		 4uuy VACUOLAR MEMBRANE
PROTEIN PEP3
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 164
ASN A 143
PRO A 184
LEU A 169
 None
 1.19A 3oi8A-4uuyA:
undetectable		 3oi8A-4uuyA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_B_LLTB261_1
(DEOXYCYTIDINE KINASE)		 4uuy VACUOLAR MEMBRANE
PROTEIN PEP3
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 343
LEU A 347
GLN A 284
LEU A 207
 None
 0.96A 3qeoB-4uuyA:
undetectable		 3qeoB-4uuyA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 4uuy VACUOLAR MEMBRANE
PROTEIN PEP3
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 261
LEU A 266
ILE A 271
ILE A 198
LEU A 314
 None
 1.07A 3vrmA-4uuyA:
undetectable		 3vrmA-4uuyA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		 4uuy VACUOLAR MEMBRANE
PROTEIN PEP3
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 168
VAL A 244
LEU A 161
THR A 212
LEU A 221
 None
 1.06A 6b54A-4uuyA:
undetectable		 6b54A-4uuyA:
23.20