SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uv6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 4uv6 APICAL MEROZOITE
ANTIGEN 1
(Plasmodium
knowlesi) 		4 / 4 VAL A 114
ARG A 317
ILE A 135
THR A 116
 None
 1.11A 3cl9A-4uv6A:
undetectable		 3cl9A-4uv6A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4uv6 APICAL MEROZOITE
ANTIGEN 1
(Plasmodium
knowlesi) 		4 / 7 SER A 198
LEU A 121
ILE A 101
PHE A 126
 None
 0.99A 3ln1C-4uv6A:
undetectable		 3ln1C-4uv6A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 4uv6 APICAL MEROZOITE
ANTIGEN 1
(Plasmodium
knowlesi) 		5 / 12 ILE A 138
MET A 194
VAL A 114
ILE A 320
ILE A 135
 None
 1.19A 3ohtA-4uv6A:
undetectable
3ohtB-4uv6A:
undetectable		 3ohtA-4uv6A:
23.11
3ohtB-4uv6A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B2000_1
(P38A)		 4uv6 APICAL MEROZOITE
ANTIGEN 1
(Plasmodium
knowlesi) 		5 / 10 ILE A 320
ILE A 135
ILE A 138
MET A 194
VAL A 114
 None
 1.18A 3ohtA-4uv6A:
undetectable
3ohtB-4uv6A:
undetectable		 3ohtA-4uv6A:
23.11
3ohtB-4uv6A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_D_BEZD1_0
(HEME-BINDING PROTEIN
HUTZ)		 4uv6 APICAL MEROZOITE
ANTIGEN 1
(Plasmodium
knowlesi) 		4 / 6 TYR A  62
PHE A 257
PRO A 361
LEU A 364
 None
 1.40A 3tgvD-4uv6A:
undetectable		 3tgvD-4uv6A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 4uv6 APICAL MEROZOITE
ANTIGEN 1
(Plasmodium
knowlesi) 		4 / 6 ASP A 367
ASN A 366
ALA A 255
ASP A 348
 None
 1.17A 4mdaA-4uv6A:
undetectable		 4mdaA-4uv6A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_A_ASCA303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 4uv6 APICAL MEROZOITE
ANTIGEN 1
(Plasmodium
knowlesi) 		4 / 7 ILE A 138
TYR A 147
PHE A 169
ARG A 146
 None
 1.06A 4o7gA-4uv6A:
undetectable
4o7gB-4uv6A:
undetectable		 4o7gA-4uv6A:
20.00
4o7gB-4uv6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4uv6 APICAL MEROZOITE
ANTIGEN 1
(Plasmodium
knowlesi) 		5 / 12 VAL A 102
LEU A 195
LYS A  99
LEU A 232
ALA A 127
 None
 1.01A 4x1kA-4uv6A:
undetectable
4x1kB-4uv6A:
undetectable		 4x1kA-4uv6A:
21.87
4x1kB-4uv6A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA605_1
(CHITINASE)		 4uv6 APICAL MEROZOITE
ANTIGEN 1
(Plasmodium
knowlesi) 		3 / 3 TRP A 344
ILE A  72
SER A 290
 None
 1.04A 5gqbA-4uv6A:
undetectable		 5gqbA-4uv6A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 4uv6 APICAL MEROZOITE
ANTIGEN 1
(Plasmodium
knowlesi) 		3 / 3 ARG A 180
LYS A 237
ARG A  66
 None
 1.33A 6c06D-4uv6A:
undetectable		 6c06D-4uv6A:
undetectable