SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uvj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 4uvj COHESIN SUBUNIT SCC3
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 816
LEU A 813
ILE A 774
GLU A 787
LEU A 781
 None
 1.16A 1wopA-4uvjA:
undetectable		 1wopA-4uvjA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		 4uvj COHESIN SUBUNIT SCC3
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 899
ARG A 902
LEU A 903
LEU A 829
 None
 0.76A 2rlfA-4uvjA:
undetectable
2rlfD-4uvjA:
undetectable		 2rlfA-4uvjA:
9.12
2rlfD-4uvjA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)		 4uvj COHESIN SUBUNIT SCC3
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 840
PHE A 832
MET A 859
TYR A 925
LEU A 903
 None
 1.47A 2w98A-4uvjA:
undetectable		 2w98A-4uvjA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4uvj COHESIN SUBUNIT SCC3
(Saccharomyces
cerevisiae) 		6 / 12 VAL A 907
ALA A 971
LEU A1030
ILE A 938
ILE A 943
ASP A 936
 None
 1.29A 3gcsA-4uvjA:
undetectable		 3gcsA-4uvjA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4uvj COHESIN SUBUNIT SCC3
(Saccharomyces
cerevisiae) 		6 / 12 VAL A 907
ALA A 971
LEU A1030
ILE A 938
ILE A 943
ASP A 936
 None
 1.27A 3hegA-4uvjA:
undetectable		 3hegA-4uvjA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I45_A_NIOA500_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN)		 4uvj COHESIN SUBUNIT SCC3
(Saccharomyces
cerevisiae) 		4 / 8 SER A 838
LEU A 833
PHE A 857
LEU A 860
 None
 0.97A 3i45A-4uvjA:
undetectable		 3i45A-4uvjA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 4uvj COHESIN SUBUNIT SCC3
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 743
ILE A 978
PHE A 979
 None
 0.67A 3j7zS-4uvjA:
0.9
3j7za-4uvjA:
undetectable		 3j7zS-4uvjA:
13.33
3j7za-4uvjA:
4.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX7_A_FOLA202_0
(DIHYDROFOLATE
REDUCTASE)		 4uvj COHESIN SUBUNIT SCC3
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 752
LEU A 816
THR A 730
ILE A 731
ILE A 758
 None
 1.06A 4nx7A-4uvjA:
undetectable		 4nx7A-4uvjA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4uvj COHESIN SUBUNIT SCC3
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 752
LEU A 816
THR A 730
ILE A 731
ILE A 758
 None
 1.02A 4pstA-4uvjA:
undetectable		 4pstA-4uvjA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4uvj COHESIN SUBUNIT SCC3
(Saccharomyces
cerevisiae) 		4 / 5 SER A 692
ALA A 691
MET A 746
LEU A 688
 None
 0.88A 5dzkb-4uvjA:
undetectable
5dzkp-4uvjA:
undetectable		 5dzkb-4uvjA:
20.15
5dzkp-4uvjA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4uvj COHESIN SUBUNIT SCC3
(Saccharomyces
cerevisiae) 		4 / 6 SER A 692
ALA A 691
MET A 746
LEU A 688
 None
 0.99A 5dzkB-4uvjA:
undetectable
5dzkP-4uvjA:
undetectable		 5dzkB-4uvjA:
20.15
5dzkP-4uvjA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4uvj COHESIN SUBUNIT SCC3
(Saccharomyces
cerevisiae) 		4 / 5 SER A 692
ALA A 691
MET A 746
LEU A 688
 None
 0.89A 5dzkc-4uvjA:
undetectable
5dzkq-4uvjA:
undetectable		 5dzkc-4uvjA:
20.15
5dzkq-4uvjA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4uvj COHESIN SUBUNIT SCC3
(Saccharomyces
cerevisiae) 		4 / 7 SER A 692
ALA A 691
MET A 746
LEU A 688
 None
 0.88A 5dzkD-4uvjA:
undetectable
5dzkR-4uvjA:
undetectable		 5dzkD-4uvjA:
20.15
5dzkR-4uvjA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4uvj COHESIN SUBUNIT SCC3
(Saccharomyces
cerevisiae) 		4 / 5 SER A 692
ALA A 691
MET A 746
LEU A 688
 None
 0.82A 5dzkf-4uvjA:
undetectable
5dzkt-4uvjA:
undetectable		 5dzkf-4uvjA:
20.15
5dzkt-4uvjA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4uvj COHESIN SUBUNIT SCC3
(Saccharomyces
cerevisiae) 		4 / 6 SER A 692
ALA A 691
MET A 746
LEU A 688
 None
 0.88A 5dzkg-4uvjA:
undetectable
5dzku-4uvjA:
undetectable		 5dzkg-4uvjA:
20.15
5dzku-4uvjA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4uvj COHESIN SUBUNIT SCC3
(Saccharomyces
cerevisiae) 		5 / 10 PHE A 770
GLY A 817
ARG A 818
ALA A 752
PHE A 709
 None
 1.33A 5zjiA-4uvjA:
undetectable
5zjiJ-4uvjA:
undetectable		 5zjiA-4uvjA:
11.40
5zjiJ-4uvjA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_0
(SERUM ALBUMIN)		 4uvj COHESIN SUBUNIT SCC3
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 967
ILE A 938
VAL A 997
LEU A1046
GLY A1029
 None
 1.22A 6a7pA-4uvjA:
2.4		 6a7pA-4uvjA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4uvj COHESIN SUBUNIT SCC3
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 860
GLY A 817
ILE A 822
PHE A 832
ILE A 810
 None
 1.14A 6ebpA-4uvjA:
undetectable		 6ebpA-4uvjA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4uvj COHESIN SUBUNIT SCC3
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 860
GLY A 817
ILE A 822
PHE A 832
ILE A 810
 None
 1.13A 6ebpB-4uvjA:
2.8		 6ebpB-4uvjA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4uvj COHESIN SUBUNIT SCC3
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 860
GLY A 817
ILE A 822
PHE A 832
ILE A 810
 None
 1.15A 6ebpC-4uvjA:
undetectable		 6ebpC-4uvjA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUP_E_DZPE502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		 4uvj COHESIN SUBUNIT SCC3
(Saccharomyces
cerevisiae) 		5 / 10 PRO A 841
MET A 843
LEU A 910
LEU A 833
PHE A 836
 None
 1.07A 6hupD-4uvjA:
0.0
6hupE-4uvjA:
0.0		 6hupD-4uvjA:
12.95
6hupE-4uvjA:
10.45