SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uvq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 4uvq THIAZOLINE
OXIDASE/SUBTILISIN-L
IKE PROTEASE
(Prochloron
sp.) 		4 / 4 THR A1127
LEU A1125
VAL A1085
LEU A1082
 None
 1.09A 1fbmB-4uvqA:
undetectable		 1fbmB-4uvqA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 4uvq THIAZOLINE
OXIDASE/SUBTILISIN-L
IKE PROTEASE
(Prochloron
sp.) 		4 / 4 GLY A1047
SER A1019
VAL A1042
LEU A1172
 None
 1.32A 1yajB-4uvqA:
undetectable		 1yajB-4uvqA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_2
(PHOSPHOLIPASE A2)		 4uvq THIAZOLINE
OXIDASE/SUBTILISIN-L
IKE PROTEASE
(Prochloron
sp.) 		4 / 5 VAL A1036
VAL A1037
GLN A1094
ARG A1024
 None
 1.38A 3bjwH-4uvqA:
undetectable		 3bjwH-4uvqA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)		 4uvq THIAZOLINE
OXIDASE/SUBTILISIN-L
IKE PROTEASE
(Prochloron
sp.) 		4 / 5 VAL A1036
VAL A1037
GLN A1094
ARG A1024
 None
 1.32A 3bjwB-4uvqA:
undetectable		 3bjwB-4uvqA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4uvq THIAZOLINE
OXIDASE/SUBTILISIN-L
IKE PROTEASE
(Prochloron
sp.) 		5 / 11 GLY A 931
ARG A 968
LEU A 970
LEU A 999
LEU A1002
 None
 1.41A 3ndvA-4uvqA:
undetectable
3ndvB-4uvqA:
undetectable		 3ndvA-4uvqA:
21.65
3ndvB-4uvqA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 4uvq THIAZOLINE
OXIDASE/SUBTILISIN-L
IKE PROTEASE
(Prochloron
sp.) 		5 / 12 PHE A1149
LEU A1078
PHE A1162
THR A1108
ALA A1111
 None
 1.11A 5ieoA-4uvqA:
2.8		 5ieoA-4uvqA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4uvq THIAZOLINE
OXIDASE/SUBTILISIN-L
IKE PROTEASE
(Prochloron
sp.) 		4 / 6 GLY A1093
LEU A1092
VAL A1042
PHE A 998
 None
 0.78A 6h7lA-4uvqA:
undetectable		 6h7lA-4uvqA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4uvq THIAZOLINE
OXIDASE/SUBTILISIN-L
IKE PROTEASE
(Prochloron
sp.) 		4 / 6 GLY A1093
LEU A1092
VAL A1042
PHE A 998
 None
 0.77A 6h7lB-4uvqA:
undetectable		 6h7lB-4uvqA:
14.86