SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uw9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 4uw9 BETA-PHOSPHOGLUCOMUT
ASE
(Pyrococcus
sp.
ST04) 		4 / 8 SER A 137
VAL A 133
ALA A 128
PHE A 142
 None
 0.93A 1dmiA-4uw9A:
undetectable
1dmiB-4uw9A:
undetectable		 1dmiA-4uw9A:
18.97
1dmiB-4uw9A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		 4uw9 BETA-PHOSPHOGLUCOMUT
ASE
(Pyrococcus
sp.
ST04) 		4 / 5 GLU A  69
LEU A  75
LEU A  72
LEU A  74
 None
 1.05A 1np1A-4uw9A:
undetectable		 1np1A-4uw9A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4uw9 BETA-PHOSPHOGLUCOMUT
ASE
(Pyrococcus
sp.
ST04) 		5 / 12 GLU A 100
PHE A  14
LEU A 221
GLY A 214
SER A 212
 None
 1.29A 2e7fA-4uw9A:
undetectable		 2e7fA-4uw9A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4uw9 BETA-PHOSPHOGLUCOMUT
ASE
(Pyrococcus
sp.
ST04) 		5 / 12 GLU A 100
PHE A  14
LEU A 221
GLY A 214
SER A 212
 None
 1.30A 2ogyA-4uw9A:
undetectable		 2ogyA-4uw9A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A933_1
(ANDROGEN RECEPTOR)		 4uw9 BETA-PHOSPHOGLUCOMUT
ASE
(Pyrococcus
sp.
ST04) 		5 / 10 ILE A 102
PHE A 213
GLY A  10
GLU A 178
TYR A 197
 None
None
MG  A1229 ( 4.5A)
MG  A1229 (-3.1A)
None
 1.48A 2piwA-4uw9A:
undetectable		 2piwA-4uw9A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 4uw9 BETA-PHOSPHOGLUCOMUT
ASE
(Pyrococcus
sp.
ST04) 		4 / 5 PHE A 104
PHE A 213
TRP A   6
GLY A 196
 None
 1.38A 2qmzA-4uw9A:
3.3
2qmzB-4uw9A:
3.0		 2qmzA-4uw9A:
20.16
2qmzB-4uw9A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_2
(PHOSPHOLIPASE A2)		 4uw9 BETA-PHOSPHOGLUCOMUT
ASE
(Pyrococcus
sp.
ST04) 		4 / 5 VAL A 177
VAL A 176
PHE A   8
ARG A 185
 None
 0.95A 3bjwH-4uw9A:
undetectable		 3bjwH-4uw9A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)		 4uw9 BETA-PHOSPHOGLUCOMUT
ASE
(Pyrococcus
sp.
ST04) 		4 / 6 VAL A 177
VAL A 176
PHE A   8
ARG A 185
 None
 0.95A 3bjwF-4uw9A:
undetectable		 3bjwF-4uw9A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)		 4uw9 BETA-PHOSPHOGLUCOMUT
ASE
(Pyrococcus
sp.
ST04) 		4 / 5 VAL A 177
VAL A 176
PHE A   8
ARG A 185
 None
 0.96A 3bjwB-4uw9A:
undetectable		 3bjwB-4uw9A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 4uw9 BETA-PHOSPHOGLUCOMUT
ASE
(Pyrococcus
sp.
ST04) 		3 / 3 ASP A 179
GLU A 100
SER A  42
 MG  A1229 (-4.7A)
None
None
 0.86A 3p2kA-4uw9A:
2.2		 3p2kA-4uw9A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4uw9 BETA-PHOSPHOGLUCOMUT
ASE
(Pyrococcus
sp.
ST04) 		4 / 6 LEU A 195
TYR A 197
LEU A 216
GLU A 215
 None
 1.11A 4f3tA-4uw9A:
undetectable		 4f3tA-4uw9A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4uw9 BETA-PHOSPHOGLUCOMUT
ASE
(Pyrococcus
sp.
ST04) 		4 / 7 LEU A 195
TYR A 197
LEU A 216
GLU A 215
 None
 1.03A 5t7bA-4uw9A:
3.5		 5t7bA-4uw9A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 4uw9 BETA-PHOSPHOGLUCOMUT
ASE
(Pyrococcus
sp.
ST04) 		4 / 5 LEU A 195
TYR A 197
LEU A 216
GLU A 215
 None
 1.24A 5weaA-4uw9A:
4.4		 5weaA-4uw9A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)		 4uw9 BETA-PHOSPHOGLUCOMUT
ASE
(Pyrococcus
sp.
ST04) 		5 / 10 ILE A 225
LEU A 224
ASN A 115
PHE A 208
LEU A 216
 None
 1.25A 5y7pH-4uw9A:
undetectable		 5y7pH-4uw9A:
20.36