SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uwm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_B_IPBB600_0
(ODORANT-BINDING
PROTEIN)		 4uwm 3,6-DIKETOCAMPHANE
1,6 MONOOXYGENASE
(Pseudomonas
putida) 		4 / 4 ILE A  38
MET A   3
VAL A 327
GLY A   6
 None
 1.44A 1e06B-4uwmA:
undetectable		 1e06B-4uwmA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)		 4uwm 3,6-DIKETOCAMPHANE
1,6 MONOOXYGENASE
(Pseudomonas
putida) 		4 / 6 MET A 294
VAL A 318
LEU A 314
PHE A 281
 FMN  A 400 (-4.6A)
None
None
PGE  A 404 (-4.5A)
 1.14A 1x8vA-4uwmA:
undetectable		 1x8vA-4uwmA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC2_0
(N8-ACTINOMYCIN D)		 4uwm 3,6-DIKETOCAMPHANE
1,6 MONOOXYGENASE
(Pseudomonas
putida) 		3 / 3 THR A 326
PRO A 324
THR A 328
 None
 0.70A 209dC-4uwmA:
undetectable		 209dC-4uwmA:
6.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 4uwm 3,6-DIKETOCAMPHANE
1,6 MONOOXYGENASE
(Pseudomonas
putida) 		4 / 5 LEU A  59
ALA A  62
TRP A  94
LEU A  95
 None
 1.16A 2oaxA-4uwmA:
undetectable		 2oaxA-4uwmA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4uwm 3,6-DIKETOCAMPHANE
1,6 MONOOXYGENASE
(Pseudomonas
putida) 		3 / 3 PRO A 208
ASN A 206
ARG A 232
 FMN  A 400 (-3.8A)
None
None
 1.03A 2qeuB-4uwmA:
undetectable		 2qeuB-4uwmA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA601_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 4uwm 3,6-DIKETOCAMPHANE
1,6 MONOOXYGENASE
(Pseudomonas
putida) 		4 / 7 GLY A  26
SER A  29
ALA A 348
ILE A  54
 None
 0.76A 3a2qA-4uwmA:
undetectable		 3a2qA-4uwmA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4uwm 3,6-DIKETOCAMPHANE
1,6 MONOOXYGENASE
(Pseudomonas
putida) 		5 / 12 PHE A 319
SER A 256
HIS A  10
LEU A 285
TYR A  12
 PGE  A 404 (-4.6A)
PGE  A 404 ( 4.1A)
FMN  A 400 (-3.7A)
None
PGE  A 404 (-4.5A)
 1.46A 3adsA-4uwmA:
undetectable		 3adsA-4uwmA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 4uwm 3,6-DIKETOCAMPHANE
1,6 MONOOXYGENASE
(Pseudomonas
putida) 		4 / 5 GLN A  32
ILE A 365
LEU A 362
PHE A 359
 None
 1.23A 3ls4L-4uwmA:
undetectable		 3ls4L-4uwmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4uwm 3,6-DIKETOCAMPHANE
1,6 MONOOXYGENASE
(Pseudomonas
putida) 		5 / 10 GLY A   6
ALA A 370
GLU A   4
MET A   3
VAL A 346
 None
 1.18A 4da7A-4uwmA:
undetectable		 4da7A-4uwmA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7A_A_MXDA1002_1
(ANDROGEN RECEPTOR)		 4uwm 3,6-DIKETOCAMPHANE
1,6 MONOOXYGENASE
(Pseudomonas
putida) 		3 / 3 GLU A 100
TRP A 191
LYS A  69
 None
PEG  A 403 (-3.7A)
None
 1.44A 4k7aA-4uwmA:
undetectable		 4k7aA-4uwmA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4uwm 3,6-DIKETOCAMPHANE
1,6 MONOOXYGENASE
(Pseudomonas
putida) 		4 / 6 LEU A 285
TYR A  12
ILE A 223
THR A 258
 None
PGE  A 404 (-4.5A)
FMN  A 400 ( 4.5A)
PGE  A 404 (-3.2A)
 0.97A 4l39A-4uwmA:
0.6		 4l39A-4uwmA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 4uwm 3,6-DIKETOCAMPHANE
1,6 MONOOXYGENASE
(Pseudomonas
putida) 		4 / 6 TRP A 234
GLY A 339
THR A 338
HIS A 253
 None
 0.77A 5ewuB-4uwmA:
undetectable		 5ewuB-4uwmA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 4uwm 3,6-DIKETOCAMPHANE
1,6 MONOOXYGENASE
(Pseudomonas
putida) 		3 / 3 TYR A 103
HIS A  78
MET A  76
 None
 1.10A 6af6A-4uwmA:
undetectable		 6af6A-4uwmA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 4uwm 3,6-DIKETOCAMPHANE
1,6 MONOOXYGENASE
(Pseudomonas
putida) 		3 / 3 THR A   5
ALA A 370
LYS A 372
 None
 0.75A 6fgcA-4uwmA:
undetectable		 6fgcA-4uwmA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 4uwm 3,6-DIKETOCAMPHANE
1,6 MONOOXYGENASE
(Pseudomonas
putida) 		3 / 3 THR A   5
ALA A 370
LYS A 372
 None
 0.72A 6fgdA-4uwmA:
undetectable		 6fgdA-4uwmA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 4uwm 3,6-DIKETOCAMPHANE
1,6 MONOOXYGENASE
(Pseudomonas
putida) 		5 / 11 ILE A 288
TRP A 289
LEU A 314
GLY A 293
PHE A 292
 None
FMN  A 400 ( 4.8A)
None
None
None
 1.34A 6r2eG-4uwmA:
undetectable		 6r2eG-4uwmA:
22.49