SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ux8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 4ux8 GDNF FAMILY RECEPTOR
ALPHA-1
(Rattus
norvegicus) 		5 / 12 TYR C 235
LEU C 212
TYR C 289
ILE C 342
PHE C 332
 None
 1.40A 1fmlA-4ux8C:
undetectable		 1fmlA-4ux8C:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_1
(GLYCINE
N-METHYLTRANSFERASE)		 4ux8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		4 / 5 ARG A 313
SER A 268
ASN A 179
SER A 307
 None
CA  A1605 (-3.3A)
CA  A1604 ( 4.9A)
None
 1.40A 1kiaB-4ux8A:
undetectable		 1kiaB-4ux8A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_1
(GLYCINE
N-METHYLTRANSFERASE)		 4ux8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		4 / 6 ARG A 313
SER A 268
ASN A 179
SER A 307
 None
CA  A1605 (-3.3A)
CA  A1604 ( 4.9A)
None
 1.41A 1kiaC-4ux8A:
undetectable		 1kiaC-4ux8A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 4ux8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		4 / 6 VAL A 502
THR A 503
GLU A 505
LEU A 410
 None
 1.13A 1s8fB-4ux8A:
undetectable		 1s8fB-4ux8A:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 4ux8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		5 / 11 GLY A 344
ALA A 342
LEU A 319
VAL A 282
VAL A 293
 None
 1.02A 1ukbA-4ux8A:
undetectable		 1ukbA-4ux8A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4ux8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		5 / 12 VAL A 376
LEU A 319
PHE A 346
SER A 345
THR A 350
 None
 1.03A 2oipC-4ux8A:
undetectable		 2oipC-4ux8A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 4ux8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
GDNF FAMILY RECEPTOR
ALPHA-1
(Homo
sapiens;
Rattus
norvegicus) 		3 / 3 ARG A 144
SER C  42
TYR A 146
 None
 0.80A 2q2hA-4ux8A:
undetectable
2q2hB-4ux8A:
undetectable		 2q2hA-4ux8A:
12.27
2q2hB-4ux8A:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4ux8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		5 / 10 ALA A 294
LEU A 296
VAL A 374
LEU A 319
PHE A 329
 None
 1.19A 3fl9A-4ux8A:
undetectable		 3fl9A-4ux8A:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4ux8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		5 / 9 ALA A 294
LEU A 296
VAL A 374
LEU A 319
PHE A 329
 None
 1.26A 3fl9D-4ux8A:
undetectable		 3fl9D-4ux8A:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4ux8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		5 / 10 ALA A 294
LEU A 296
VAL A 374
LEU A 319
PHE A 329
 None
 1.20A 3fl9F-4ux8A:
undetectable		 3fl9F-4ux8A:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4ux8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		5 / 12 VAL A 376
LEU A 319
PHE A 346
SER A 345
THR A 350
 None
 0.91A 3hj3C-4ux8A:
undetectable		 3hj3C-4ux8A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I45_A_NIOA500_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN)		 4ux8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		4 / 8 PHE A  66
SER A 128
LEU A  29
PHE A  31
 None
 1.03A 3i45A-4ux8A:
undetectable		 3i45A-4ux8A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 4ux8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		3 / 3 PHE A 147
TYR A  36
LEU A 119
 None
 0.73A 3keeB-4ux8A:
undetectable		 3keeB-4ux8A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4ux8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		3 / 3 PHE A 147
TYR A  36
LEU A 119
 None
 0.74A 3sueB-4ux8A:
undetectable		 3sueB-4ux8A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4ux8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		5 / 12 VAL A 376
PHE A 346
SER A 345
VAL A 282
THR A 350
 None
 1.14A 4eckB-4ux8A:
undetectable		 4eckB-4ux8A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_A_H4BA804_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ux8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		4 / 7 ARG A 189
VAL A 254
PHE A 167
GLU A 164
 None
 1.30A 4jseA-4ux8A:
undetectable
4jseB-4ux8A:
undetectable		 4jseA-4ux8A:
20.68
4jseB-4ux8A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ux8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		4 / 7 PHE A 167
GLU A 164
ARG A 189
VAL A 254
 None
 1.27A 4jseA-4ux8A:
undetectable
4jseB-4ux8A:
undetectable		 4jseA-4ux8A:
20.68
4jseB-4ux8A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDC_A_ASDA404_1
(3-KETOSTEROID
9ALPHA-HYDROXYLASE
OXYGENASE)		 4ux8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		5 / 12 VAL A 298
ALA A 274
MET A 370
ASP A 277
LEU A 372
 None
 1.14A 4qdcA-4ux8A:
undetectable		 4qdcA-4ux8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 4ux8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		5 / 12 LEU A 118
ASN A  83
LEU A  95
PHE A 147
ILE A  86
 None
 1.26A 5dv4A-4ux8A:
undetectable		 5dv4A-4ux8A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4ux8 GDNF FAMILY RECEPTOR
ALPHA-1
(Rattus
norvegicus) 		4 / 6 PHE C 328
SER C 318
LEU C 326
LEU C 329
 None
 1.28A 5dzke-4ux8C:
undetectable
5dzks-4ux8C:
undetectable		 5dzke-4ux8C:
18.75
5dzks-4ux8C:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 4ux8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		5 / 10 GLY A 183
THR A 225
LEU A  56
GLN A  89
PHE A  66
 None
 1.08A 5fhzC-4ux8A:
undetectable		 5fhzC-4ux8A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		 4ux8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		5 / 12 PHE A 188
VAL A 193
GLN A 187
PRO A 162
ILE A 200
 None
 1.45A 6becA-4ux8A:
undetectable
6becB-4ux8A:
undetectable
6becC-4ux8A:
undetectable		 6becA-4ux8A:
22.06
6becB-4ux8A:
22.06
6becC-4ux8A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4ux8 GDNF FAMILY RECEPTOR
ALPHA-1
(Rattus
norvegicus) 		3 / 3 ARG C 190
HIS C 193
ARG C 197
 None
 1.03A 6dwdD-4ux8C:
undetectable		 6dwdD-4ux8C:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		 4ux8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		4 / 8 TRP A 324
GLY A 344
THR A 328
PHE A 285
 None
 1.00A 6eqpA-4ux8A:
undetectable		 6eqpA-4ux8A:
8.08