SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uxa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4uxa CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN
(Granulicella
tundricola) 		5 / 12 HIS A  94
HIS A 110
HIS A  40
HIS A  53
THR A  50
 MN  A 200 (-3.6A)
None
None
MN  A 200 (-3.6A)
None
 1.33A 2c6nB-4uxaA:
undetectable		 2c6nB-4uxaA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4uxa CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN
(Granulicella
tundricola) 		3 / 3 HIS A  96
HIS A  53
HIS A  94
 MN  A 200 (-3.7A)
MN  A 200 (-3.6A)
MN  A 200 (-3.6A)
 0.75A 3ag4A-4uxaA:
undetectable		 3ag4A-4uxaA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 4uxa CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN
(Granulicella
tundricola) 		4 / 8 PHE A  29
VAL A  37
LEU A 107
HIS A 110
 None
 1.15A 4f5zA-4uxaA:
undetectable		 4f5zA-4uxaA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 4uxa CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN
(Granulicella
tundricola) 		4 / 7 HIS A  55
HIS A  40
VAL A 118
ALA A 117
 MN  A 200 (-3.7A)
None
None
None
 0.89A 4p6sA-4uxaA:
undetectable		 4p6sA-4uxaA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_C_AZMC303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4uxa CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN
(Granulicella
tundricola) 		5 / 11 HIS A  94
HIS A  96
HIS A  53
VAL A 118
ALA A 108
 MN  A 200 (-3.6A)
MN  A 200 (-3.7A)
MN  A 200 (-3.6A)
None
None
 1.48A 4ygfC-4uxaA:
undetectable		 4ygfC-4uxaA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 4uxa CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN
(Granulicella
tundricola) 		4 / 7 HIS A  55
HIS A  40
VAL A 118
ALA A 117
 MN  A 200 (-3.7A)
None
None
None
 0.89A 5i3aA-4uxaA:
undetectable		 5i3aA-4uxaA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 4uxa CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN
(Granulicella
tundricola) 		4 / 7 HIS A  55
HIS A  40
VAL A 118
ALA A 117
 MN  A 200 (-3.7A)
None
None
None
 0.89A 5i3aB-4uxaA:
undetectable		 5i3aB-4uxaA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 4uxa CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN
(Granulicella
tundricola) 		4 / 7 HIS A  55
HIS A  40
VAL A 118
ALA A 117
 MN  A 200 (-3.7A)
None
None
None
 0.90A 5i3bA-4uxaA:
undetectable		 5i3bA-4uxaA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_G_EZLG303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4uxa CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN
(Granulicella
tundricola) 		5 / 9 HIS A  94
HIS A  96
HIS A  53
VAL A 118
ALA A 108
 MN  A 200 (-3.6A)
MN  A 200 (-3.7A)
MN  A 200 (-3.6A)
None
None
 1.41A 5tt3G-4uxaA:
undetectable		 5tt3G-4uxaA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_2
(RIBOFLAVIN LYASE)		 4uxa CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN
(Granulicella
tundricola) 		4 / 5 GLN A   9
ASP A  26
SER A  11
ARG A  24
 None
 1.48A 5w4zA-4uxaA:
undetectable		 5w4zA-4uxaA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_G_6ELG501_0
(PROTEIN CEREBLON)		 4uxa CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN
(Granulicella
tundricola) 		4 / 8 HIS A  53
TRP A  18
HIS A  40
THR A  42
 MN  A 200 (-3.6A)
None
None
None
 1.14A 5yj1G-4uxaA:
undetectable
5yj1Y-4uxaA:
undetectable		 5yj1G-4uxaA:
17.56
5yj1Y-4uxaA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_T_6ELT501_0
(PROTEIN CEREBLON)		 4uxa CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN
(Granulicella
tundricola) 		4 / 8 HIS A  40
THR A  42
HIS A  53
TRP A  18
 None
None
MN  A 200 (-3.6A)
None
 1.14A 5yj1k-4uxaA:
undetectable
5yj1t-4uxaA:
undetectable		 5yj1k-4uxaA:
17.56
5yj1t-4uxaA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 4uxa CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN
(Granulicella
tundricola) 		3 / 3 HIS A  53
HIS A  94
HIS A  55
 MN  A 200 (-3.6A)
MN  A 200 (-3.6A)
MN  A 200 (-3.7A)
 0.48A 5zrdA-4uxaA:
undetectable		 5zrdA-4uxaA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 4uxa CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN
(Granulicella
tundricola) 		3 / 3 HIS A  94
HIS A  53
HIS A  96
 MN  A 200 (-3.6A)
MN  A 200 (-3.6A)
MN  A 200 (-3.7A)
 0.59A 5zrdA-4uxaA:
undetectable		 5zrdA-4uxaA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC604_0
(TYROSINASE)		 4uxa CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN
(Granulicella
tundricola) 		4 / 4 HIS A  53
HIS A  96
HIS A  94
HIS A  55
 MN  A 200 (-3.6A)
MN  A 200 (-3.7A)
MN  A 200 (-3.6A)
MN  A 200 (-3.7A)
 1.15A 5zrdC-4uxaA:
undetectable		 5zrdC-4uxaA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD607_0
(TYROSINASE)		 4uxa CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN
(Granulicella
tundricola) 		4 / 4 HIS A  53
HIS A  96
HIS A  94
HIS A  55
 MN  A 200 (-3.6A)
MN  A 200 (-3.7A)
MN  A 200 (-3.6A)
MN  A 200 (-3.7A)
 1.17A 5zrdD-4uxaA:
undetectable		 5zrdD-4uxaA:
12.80