SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uxd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_2
(MINERALOCORTICOID
RECEPTOR)		 4uxd 2-DEHYDRO-3-DEOXY-D-
GLUCONATE/2-DEHYDRO-
3-DEOXY-PHOSPHOGLUCO
NATE ALDOLASE
(Picrophilus
torridus) 		4 / 4 LEU A 226
LEU A 193
SER A 192
LEU A 188
 None
 1.13A 1ya3A-4uxdA:
undetectable		 1ya3A-4uxdA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2001_1
(SERUM ALBUMIN)		 4uxd 2-DEHYDRO-3-DEOXY-D-
GLUCONATE/2-DEHYDRO-
3-DEOXY-PHOSPHOGLUCO
NATE ALDOLASE
(Picrophilus
torridus) 		5 / 11 LEU A 121
ILE A 120
VAL A  75
GLY A  76
SER A 154
 None
 0.95A 2bxeA-4uxdA:
undetectable		 2bxeA-4uxdA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2001_1
(SERUM ALBUMIN)		 4uxd 2-DEHYDRO-3-DEOXY-D-
GLUCONATE/2-DEHYDRO-
3-DEOXY-PHOSPHOGLUCO
NATE ALDOLASE
(Picrophilus
torridus) 		5 / 12 LEU A 121
ILE A 120
VAL A  75
GLY A  76
SER A 154
 None
 0.99A 2bxeB-4uxdA:
undetectable		 2bxeB-4uxdA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 4uxd 2-DEHYDRO-3-DEOXY-D-
GLUCONATE/2-DEHYDRO-
3-DEOXY-PHOSPHOGLUCO
NATE ALDOLASE
(Picrophilus
torridus) 		4 / 8 TYR A 263
ASN A 247
GLU A 251
TYR A 268
 None
 1.01A 2fl5E-4uxdA:
undetectable
2fl5F-4uxdA:
undetectable		 2fl5E-4uxdA:
21.53
2fl5F-4uxdA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 4uxd 2-DEHYDRO-3-DEOXY-D-
GLUCONATE/2-DEHYDRO-
3-DEOXY-PHOSPHOGLUCO
NATE ALDOLASE
(Picrophilus
torridus) 		4 / 5 GLY A  17
ARG A 264
GLU A  55
PHE A  51
 None
 1.01A 4r82A-4uxdA:
undetectable
4r82B-4uxdA:
undetectable		 4r82A-4uxdA:
19.72
4r82B-4uxdA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4uxd 2-DEHYDRO-3-DEOXY-D-
GLUCONATE/2-DEHYDRO-
3-DEOXY-PHOSPHOGLUCO
NATE ALDOLASE
(Picrophilus
torridus) 		4 / 4 LEU A 100
GLY A  76
SER A  77
SER A  78
 None
 1.29A 5uunA-4uxdA:
undetectable		 5uunA-4uxdA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB306_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4uxd 2-DEHYDRO-3-DEOXY-D-
GLUCONATE/2-DEHYDRO-
3-DEOXY-PHOSPHOGLUCO
NATE ALDOLASE
(Picrophilus
torridus) 		4 / 4 LEU A 100
GLY A  76
SER A  77
SER A  78
 None
 1.31A 5uunB-4uxdA:
undetectable		 5uunB-4uxdA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 4uxd 2-DEHYDRO-3-DEOXY-D-
GLUCONATE/2-DEHYDRO-
3-DEOXY-PHOSPHOGLUCO
NATE ALDOLASE
(Picrophilus
torridus) 		3 / 3 PHE A  62
ASP A  58
LYS A  61
 None
 0.84A 6awtD-4uxdA:
undetectable		 6awtD-4uxdA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B50_A_OAQA302_0
(SULFOTRANSFERASE
OXAMNIQUINE
RESISTANCE PROTEIN)		 4uxd 2-DEHYDRO-3-DEOXY-D-
GLUCONATE/2-DEHYDRO-
3-DEOXY-PHOSPHOGLUCO
NATE ALDOLASE
(Picrophilus
torridus) 		5 / 12 LEU A 193
VAL A 201
ASP A 160
PHE A 168
SER A 192
 None
GOL  A1275 ( 4.1A)
GOL  A1282 ( 4.9A)
None
None
 1.41A 6b50A-4uxdA:
undetectable		 6b50A-4uxdA:
20.07