SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uxv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 4uxv SEPTATION RING
FORMATION REGULATOR
EZRA
(Bacillus
subtilis) 		4 / 5 TYR A 211
PRO A 216
LEU A 219
THR A 272
 None
 1.36A 1i2wA-4uxvA:
undetectable		 1i2wA-4uxvA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)		 4uxv SEPTATION RING
FORMATION REGULATOR
EZRA
(Bacillus
subtilis) 		5 / 12 LEU A 419
LEU A 422
ILE A 426
SER A 488
LEU A 477
 None
 0.90A 1xdkF-4uxvA:
undetectable		 1xdkF-4uxvA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 4uxv SEPTATION RING
FORMATION REGULATOR
EZRA
(Bacillus
subtilis) 		3 / 3 VAL A 301
GLU A 298
GLU A 302
 None
 0.81A 2nv4A-4uxvA:
undetectable		 2nv4A-4uxvA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 4uxv SEPTATION RING
FORMATION REGULATOR
EZRA
(Bacillus
subtilis) 		5 / 12 VAL A 498
LEU A 433
SER A 443
ILE A 438
TYR A 534
 None
 1.11A 2w3vA-4uxvA:
undetectable		 2w3vA-4uxvA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 4uxv SEPTATION RING
FORMATION REGULATOR
EZRA
(Bacillus
subtilis) 		4 / 7 ASN A 204
LEU A 168
ASP A 171
LYS A 170
 None
 0.92A 3lslA-4uxvA:
undetectable
3lslD-4uxvA:
undetectable		 3lslA-4uxvA:
18.85
3lslD-4uxvA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 4uxv SEPTATION RING
FORMATION REGULATOR
EZRA
(Bacillus
subtilis) 		4 / 7 ASN A 204
LEU A 168
ASP A 171
LYS A 170
 None
 0.88A 3lslA-4uxvA:
undetectable
3lslD-4uxvA:
undetectable		 3lslA-4uxvA:
18.85
3lslD-4uxvA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		 4uxv SEPTATION RING
FORMATION REGULATOR
EZRA
(Bacillus
subtilis) 		4 / 6 ASN A 204
LEU A 168
ASP A 171
LYS A 170
 None
 0.87A 3lslG-4uxvA:
undetectable		 3lslG-4uxvA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_1
(WBDD)		 4uxv SEPTATION RING
FORMATION REGULATOR
EZRA
(Bacillus
subtilis) 		4 / 6 GLN A 406
ARG A 340
GLU A 417
LEU A 408
 None
 1.32A 4ax8A-4uxvA:
undetectable		 4ax8A-4uxvA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4uxv SEPTATION RING
FORMATION REGULATOR
EZRA
(Bacillus
subtilis) 		4 / 7 ASP A  88
ASP A 109
ASN A 102
ASP A  30
 None
 1.12A 4feuB-4uxvA:
undetectable		 4feuB-4uxvA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4uxv SEPTATION RING
FORMATION REGULATOR
EZRA
(Bacillus
subtilis) 		4 / 8 ASP A  88
ASP A 109
ASN A 102
ASP A  30
 None
 0.89A 4feuD-4uxvA:
undetectable		 4feuD-4uxvA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4uxv SEPTATION RING
FORMATION REGULATOR
EZRA
(Bacillus
subtilis) 		4 / 8 ASP A  88
ASP A 109
ASN A 102
ASP A  30
 None
 0.97A 4feuF-4uxvA:
undetectable		 4feuF-4uxvA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4uxv SEPTATION RING
FORMATION REGULATOR
EZRA
(Bacillus
subtilis) 		4 / 7 ASP A  88
ASP A 109
ASN A 102
ASP A  30
 None
 0.89A 4fevB-4uxvA:
undetectable		 4fevB-4uxvA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4uxv SEPTATION RING
FORMATION REGULATOR
EZRA
(Bacillus
subtilis) 		4 / 7 ASP A  88
ASP A 109
ASN A 102
ASP A  30
 None
 0.96A 4fevD-4uxvA:
undetectable		 4fevD-4uxvA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4uxv SEPTATION RING
FORMATION REGULATOR
EZRA
(Bacillus
subtilis) 		4 / 7 ASP A  88
ASP A 109
ASN A 102
ASP A  30
 None
 0.97A 4fevF-4uxvA:
undetectable		 4fevF-4uxvA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4uxv SEPTATION RING
FORMATION REGULATOR
EZRA
(Bacillus
subtilis) 		4 / 7 ASP A  88
ASP A 109
ASN A 102
ASP A  30
 None
 0.87A 4fewB-4uxvA:
undetectable		 4fewB-4uxvA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4uxv SEPTATION RING
FORMATION REGULATOR
EZRA
(Bacillus
subtilis) 		4 / 8 ASP A  88
ASP A 109
ASN A 102
ASP A  30
 None
 0.97A 4fewD-4uxvA:
undetectable		 4fewD-4uxvA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4uxv SEPTATION RING
FORMATION REGULATOR
EZRA
(Bacillus
subtilis) 		4 / 8 ASP A  88
ASP A 109
ASN A 102
ASP A  30
 None
 0.95A 4fewF-4uxvA:
undetectable		 4fewF-4uxvA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4uxv SEPTATION RING
FORMATION REGULATOR
EZRA
(Bacillus
subtilis) 		4 / 7 ASP A  88
ASP A 109
ASN A 102
ASP A  30
 None
 0.97A 4fexB-4uxvA:
undetectable		 4fexB-4uxvA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4uxv SEPTATION RING
FORMATION REGULATOR
EZRA
(Bacillus
subtilis) 		4 / 8 ASP A  88
ASP A 109
ASN A 102
ASP A  30
 None
 0.97A 4gkhB-4uxvA:
undetectable		 4gkhB-4uxvA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4uxv SEPTATION RING
FORMATION REGULATOR
EZRA
(Bacillus
subtilis) 		4 / 8 ASP A  88
ASP A 109
ASN A 102
ASP A  30
 None
 0.90A 4gkhD-4uxvA:
undetectable		 4gkhD-4uxvA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4uxv SEPTATION RING
FORMATION REGULATOR
EZRA
(Bacillus
subtilis) 		4 / 8 ASP A  88
ASP A 109
ASN A 102
ASP A  30
 None
 0.95A 4gkhF-4uxvA:
undetectable		 4gkhF-4uxvA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4uxv SEPTATION RING
FORMATION REGULATOR
EZRA
(Bacillus
subtilis) 		4 / 7 ASP A  88
ASP A 109
ASN A 102
ASP A  30
 None
 0.99A 4gkhG-4uxvA:
undetectable		 4gkhG-4uxvA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_J_KANJ301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4uxv SEPTATION RING
FORMATION REGULATOR
EZRA
(Bacillus
subtilis) 		4 / 6 ASP A  88
ASP A 109
ASN A 102
ASP A  30
 None
 0.91A 4gkhJ-4uxvA:
undetectable		 4gkhJ-4uxvA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4uxv SEPTATION RING
FORMATION REGULATOR
EZRA
(Bacillus
subtilis) 		4 / 8 ASP A  88
ASP A 109
ASN A 102
ASP A  30
 None
 0.98A 4gkhC-4uxvA:
undetectable
4gkhK-4uxvA:
undetectable		 4gkhC-4uxvA:
17.71
4gkhK-4uxvA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4uxv SEPTATION RING
FORMATION REGULATOR
EZRA
(Bacillus
subtilis) 		4 / 8 ASP A  88
ASP A 109
ASN A 102
ASP A  30
 None
 0.96A 4gkiA-4uxvA:
undetectable		 4gkiA-4uxvA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4uxv SEPTATION RING
FORMATION REGULATOR
EZRA
(Bacillus
subtilis) 		4 / 8 ASP A  88
ASP A 109
ASN A 102
ASP A  30
 None
 0.96A 4gkiC-4uxvA:
undetectable		 4gkiC-4uxvA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4uxv SEPTATION RING
FORMATION REGULATOR
EZRA
(Bacillus
subtilis) 		4 / 8 ASP A  88
ASP A 109
ASN A 102
ASP A  30
 None
 0.95A 4gkiE-4uxvA:
undetectable
4gkiG-4uxvA:
undetectable		 4gkiE-4uxvA:
17.71
4gkiG-4uxvA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4uxv SEPTATION RING
FORMATION REGULATOR
EZRA
(Bacillus
subtilis) 		4 / 6 ASN A 404
GLU A 411
GLU A 337
GLU A 345
 None
 1.12A 4mi4A-4uxvA:
undetectable		 4mi4A-4uxvA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4uxv SEPTATION RING
FORMATION REGULATOR
EZRA
(Bacillus
subtilis) 		4 / 7 ASN A 404
GLU A 411
GLU A 337
GLU A 345
 None
 1.11A 4mi4B-4uxvA:
undetectable
4mi4C-4uxvA:
undetectable		 4mi4B-4uxvA:
16.61
4mi4C-4uxvA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4uxv SEPTATION RING
FORMATION REGULATOR
EZRA
(Bacillus
subtilis) 		4 / 7 ASN A 404
GLU A 411
GLU A 337
GLU A 345
 None
 1.13A 4mi4A-4uxvA:
undetectable
4mi4C-4uxvA:
undetectable		 4mi4A-4uxvA:
16.61
4mi4C-4uxvA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4uxv SEPTATION RING
FORMATION REGULATOR
EZRA
(Bacillus
subtilis) 		4 / 8 ASN A 404
GLU A 411
GLU A 337
GLU A 345
 None
 1.14A 4mj8A-4uxvA:
undetectable
4mj8C-4uxvA:
undetectable		 4mj8A-4uxvA:
16.15
4mj8C-4uxvA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4uxv SEPTATION RING
FORMATION REGULATOR
EZRA
(Bacillus
subtilis) 		4 / 8 ILE A 119
GLU A 120
GLU A 116
LEU A 112
 None
 0.91A 4mj8A-4uxvA:
undetectable		 4mj8A-4uxvA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4uxv SEPTATION RING
FORMATION REGULATOR
EZRA
(Bacillus
subtilis) 		4 / 8 ASN A 404
GLU A 411
GLU A 337
GLU A 345
 None
 1.12A 4mj8B-4uxvA:
undetectable
4mj8C-4uxvA:
undetectable		 4mj8B-4uxvA:
16.15
4mj8C-4uxvA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4uxv SEPTATION RING
FORMATION REGULATOR
EZRA
(Bacillus
subtilis) 		4 / 7 ASN A 404
GLU A 411
GLU A 337
GLU A 345
 None
 1.22A 4mj8C-4uxvA:
undetectable		 4mj8C-4uxvA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 4uxv SEPTATION RING
FORMATION REGULATOR
EZRA
(Bacillus
subtilis) 		3 / 3 LEU A 168
LEU A 172
TRP A 176
 None
 0.92A 5nwuA-4uxvA:
undetectable		 5nwuA-4uxvA:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_1
(SCRFP-TAG,GP41)		 4uxv SEPTATION RING
FORMATION REGULATOR
EZRA
(Bacillus
subtilis) 		5 / 12 GLY A 344
ASN A 469
LEU A 408
GLU A 333
LEU A 405
 None
 1.14A 5nwwA-4uxvA:
undetectable		 5nwwA-4uxvA:
6.44