SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uy4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4uy4 SPINDLIN-4
(Homo
sapiens) 		4 / 6 LEU A  89
ASP A  92
ILE A 228
ARG A  94
 None
 1.10A 1mt1A-4uy4A:
undetectable
1mt1F-4uy4A:
undetectable		 1mt1A-4uy4A:
15.46
1mt1F-4uy4A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB8_0
(GRAMICIDIN A)		 4uy4 SPINDLIN-4
(Homo
sapiens) 		4 / 5 VAL A  41
GLY A  42
VAL A  63
TRP A 147
 None
 1.28A 1tkqB-4uy4A:
undetectable		 1tkqB-4uy4A:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 4uy4 SPINDLIN-4
(Homo
sapiens) 		4 / 8 VAL A  41
GLY A  42
THR A  62
ILE A  75
 None
None
None
GOL  A1237 ( 4.0A)
 0.79A 2a1mB-4uy4A:
undetectable		 2a1mB-4uy4A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4uy4 SPINDLIN-4
(Homo
sapiens) 		3 / 3 LEU A 172
TRP A 133
TYR A 161
 None
 0.88A 3aicB-4uy4A:
undetectable		 3aicB-4uy4A:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4uy4 SPINDLIN-4
(Homo
sapiens) 		3 / 3 LEU A 172
TRP A 133
TYR A 161
 None
 0.89A 3aicE-4uy4A:
undetectable		 3aicE-4uy4A:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4uy4 SPINDLIN-4
(Homo
sapiens) 		3 / 3 LEU A 172
TRP A 133
TYR A 161
 None
 0.87A 3aicG-4uy4A:
undetectable		 3aicG-4uy4A:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4uy4 SPINDLIN-4
(Homo
sapiens) 		3 / 3 LEU A 172
TRP A 133
TYR A 161
 None
 0.88A 3aicH-4uy4A:
undetectable		 3aicH-4uy4A:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		 4uy4 SPINDLIN-4
(Homo
sapiens) 		5 / 9 ILE A  75
ILE A 210
LYS A 223
LEU A  73
TYR A  78
 GOL  A1237 ( 4.0A)
GOL  A1237 (-4.0A)
None
None
None
 1.28A 3f78A-4uy4A:
undetectable		 3f78A-4uy4A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_B_ICFB2_1
(INTEGRIN ALPHA-L)		 4uy4 SPINDLIN-4
(Homo
sapiens) 		5 / 9 ILE A  75
ILE A 210
LYS A 223
LEU A  73
TYR A  78
 GOL  A1237 ( 4.0A)
GOL  A1237 (-4.0A)
None
None
None
 1.27A 3f78B-4uy4A:
undetectable		 3f78B-4uy4A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UPR_A_1KXA277_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 4uy4 SPINDLIN-4
(Homo
sapiens) 		5 / 10 ILE A  76
ASP A  92
TYR A  85
ILE A 228
TRP A  49
 None
 1.28A 3uprA-4uy4A:
undetectable		 3uprA-4uy4A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UPR_C_1KXC277_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 4uy4 SPINDLIN-4
(Homo
sapiens) 		5 / 10 ILE A  76
ASP A  92
TYR A  85
ILE A 228
TRP A  49
 None
 1.28A 3uprC-4uy4A:
undetectable		 3uprC-4uy4A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4uy4 SPINDLIN-4
(Homo
sapiens) 		3 / 3 LYS A 223
ARG A  94
LEU A  87
 None
 0.97A 3v4tE-4uy4A:
undetectable		 3v4tE-4uy4A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)		 4uy4 SPINDLIN-4
(Homo
sapiens) 		3 / 3 LYS A 216
PRO A 217
SER A 218
 None
 0.37A 4k50I-4uy4A:
undetectable		 4k50I-4uy4A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U98_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 4uy4 SPINDLIN-4
(Homo
sapiens) 		5 / 10 ILE A  76
ASP A  92
TYR A  85
ILE A 228
TRP A  49
 None
 1.26A 5u98A-4uy4A:
undetectable		 5u98A-4uy4A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U98_D_1KXD301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 4uy4 SPINDLIN-4
(Homo
sapiens) 		5 / 10 ILE A  76
ASP A  92
TYR A  85
ILE A 228
TRP A  49
 None
 1.29A 5u98D-4uy4A:
undetectable		 5u98D-4uy4A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB5_A_NMYA301_0
(AAC(3)-IIIB PROTEIN)		 4uy4 SPINDLIN-4
(Homo
sapiens) 		5 / 11 TYR A 161
ASP A  82
TYR A 152
ASP A 169
HIS A 125
 None
 1.36A 6mb5A-4uy4A:
undetectable		 6mb5A-4uy4A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_B_NMYB302_0
(AAC(3)-IIIB PROTEIN)		 4uy4 SPINDLIN-4
(Homo
sapiens) 		5 / 10 TYR A 161
ASP A  82
TYR A 152
ASP A 169
HIS A 125
 None
 1.37A 6mb9B-4uy4A:
undetectable		 6mb9B-4uy4A:
15.71