SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uya'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 4uya MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLK4
(Homo
sapiens) 		4 / 7 THR A 362
GLY A 355
LEU A 432
TYR A 344
 None
 1.02A 1gtiE-4uyaA:
undetectable		 1gtiE-4uyaA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4uya MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLK4
(Homo
sapiens) 		4 / 6 GLY A 324
VAL A 315
ALA A 312
SER A 329
 None
 0.89A 1p6kA-4uyaA:
undetectable		 1p6kA-4uyaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4uya MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLK4
(Homo
sapiens) 		4 / 6 GLN A 243
ASN A 239
ASN A 268
LEU A 264
 None
None
MG  A1439 ( 3.0A)
None
 1.19A 2nyrA-4uyaA:
undetectable		 2nyrA-4uyaA:
20.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 4uya MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLK4
(Homo
sapiens) 		6 / 12 GLY A 131
VAL A 138
ALA A 149
LEU A 200
GLY A 206
ASP A 289
 AGS  A1438 ( 3.8A)
AGS  A1438 (-4.4A)
AGS  A1438 (-3.4A)
AGS  A1438 (-3.6A)
None
AGS  A1438 (-2.7A)
 0.71A 2wgjA-4uyaA:
25.3		 2wgjA-4uyaA:
31.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 4uya MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLK4
(Homo
sapiens) 		6 / 9 VAL A 138
ALA A 149
LEU A 200
GLY A 206
LEU A 270
ASP A 289
 AGS  A1438 (-4.4A)
AGS  A1438 (-3.4A)
AGS  A1438 (-3.6A)
None
AGS  A1438 (-4.7A)
AGS  A1438 (-2.7A)
 0.67A 2xp2A-4uyaA:
27.3		 2xp2A-4uyaA:
31.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 4uya MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLK4
(Homo
sapiens) 		6 / 12 VAL A 138
ALA A 149
GLY A 206
LEU A 270
THR A 288
PHE A 290
 AGS  A1438 (-4.4A)
AGS  A1438 (-3.4A)
None
AGS  A1438 (-4.7A)
AGS  A1438 ( 4.7A)
None
 0.62A 3bbtB-4uyaA:
26.6		 3bbtB-4uyaA:
34.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 4uya MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLK4
(Homo
sapiens) 		7 / 12 VAL A 138
ALA A 149
LEU A 198
GLY A 206
LEU A 270
THR A 288
PHE A 290
 AGS  A1438 (-4.4A)
AGS  A1438 (-3.4A)
None
None
AGS  A1438 (-4.7A)
AGS  A1438 ( 4.7A)
None
 0.61A 3bbtD-4uyaA:
20.7		 3bbtD-4uyaA:
34.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 4uya MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLK4
(Homo
sapiens) 		6 / 12 VAL A 138
ALA A 149
ILE A 184
ALA A 203
LEU A 251
HIS A 261
 AGS  A1438 (-4.4A)
AGS  A1438 (-3.4A)
AGS  A1438 (-4.2A)
AGS  A1438 (-3.7A)
None
None
 0.54A 3rgfA-4uyaA:
20.7		 3rgfA-4uyaA:
25.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4uya MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLK4
(Homo
sapiens) 		6 / 9 VAL A 138
ALA A 149
LEU A 200
GLY A 206
LEU A 270
ASP A 289
 AGS  A1438 (-4.4A)
AGS  A1438 (-3.4A)
AGS  A1438 (-3.6A)
None
AGS  A1438 (-4.7A)
AGS  A1438 (-2.7A)
 0.72A 4anqA-4uyaA:
27.0		 4anqA-4uyaA:
33.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4uya MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLK4
(Homo
sapiens) 		7 / 12 VAL A 138
ALA A 149
ILE A 184
ASP A 263
ASN A 268
LEU A 270
ASP A 289
 AGS  A1438 (-4.4A)
AGS  A1438 (-3.4A)
AGS  A1438 (-4.2A)
AGS  A1438 (-3.7A)
MG  A1439 ( 3.0A)
AGS  A1438 (-4.7A)
AGS  A1438 (-2.7A)
 0.73A 4i41A-4uyaA:
20.4		 4i41A-4uyaA:
26.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 4uya MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLK4
(Homo
sapiens) 		7 / 12 GLY A 131
VAL A 138
ALA A 149
LEU A 186
LEU A 198
GLY A 206
LEU A 270
 AGS  A1438 ( 3.8A)
AGS  A1438 (-4.4A)
AGS  A1438 (-3.4A)
None
None
None
AGS  A1438 (-4.7A)
 0.56A 4ifgA-4uyaA:
23.0		 4ifgA-4uyaA:
25.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4uya MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLK4
(Homo
sapiens) 		5 / 7 VAL A 138
ILE A 184
ALA A 203
ARG A 262
ILE A 287
 AGS  A1438 (-4.4A)
AGS  A1438 (-4.2A)
AGS  A1438 (-3.7A)
None
None
 0.78A 4uxqA-4uyaA:
25.4		 4uxqA-4uyaA:
32.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4uya MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLK4
(Homo
sapiens) 		4 / 8 ILE A 184
ARG A 262
LEU A 270
ILE A 287
 AGS  A1438 (-4.2A)
None
AGS  A1438 (-4.7A)
None
 0.67A 4v04A-4uyaA:
26.0		 4v04A-4uyaA:
32.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4uya MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLK4
(Homo
sapiens) 		6 / 9 VAL A 138
ALA A 149
LEU A 200
GLY A 206
LEU A 270
ASP A 289
 AGS  A1438 (-4.4A)
AGS  A1438 (-3.4A)
AGS  A1438 (-3.6A)
None
AGS  A1438 (-4.7A)
AGS  A1438 (-2.7A)
 0.73A 5aaaA-4uyaA:
27.1		 5aaaA-4uyaA:
32.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 4uya MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLK4
(Homo
sapiens) 		6 / 11 GLY A 131
VAL A 138
ALA A 149
LEU A 200
ALA A 203
LEU A 270
 AGS  A1438 ( 3.8A)
AGS  A1438 (-4.4A)
AGS  A1438 (-3.4A)
AGS  A1438 (-3.6A)
AGS  A1438 (-3.7A)
AGS  A1438 (-4.7A)
 0.40A 5lvnA-4uyaA:
22.7		 5lvnA-4uyaA:
26.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4uya MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLK4
(Homo
sapiens) 		6 / 12 GLY A 131
VAL A 138
ALA A 149
LEU A 198
LEU A 270
THR A 288
 AGS  A1438 ( 3.8A)
AGS  A1438 (-4.4A)
AGS  A1438 (-3.4A)
None
AGS  A1438 (-4.7A)
AGS  A1438 ( 4.7A)
 0.75A 5yu9B-4uyaA:
26.0		 5yu9B-4uyaA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4uya MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLK4
(Homo
sapiens) 		5 / 12 VAL A 138
ALA A 149
LEU A 198
GLY A 206
THR A 288
 AGS  A1438 (-4.4A)
AGS  A1438 (-3.4A)
None
None
AGS  A1438 ( 4.7A)
 0.63A 5yu9C-4uyaA:
25.7		 5yu9C-4uyaA:
16.00