SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uyb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 4uyb SEC14-LIKE PROTEIN 3
(Homo
sapiens) 		5 / 11 CYH A 254
LEU A 190
LEU A 237
CYH A  89
ILE A 152
 EDO  A1403 ( 3.8A)
None
None
EDO  A1403 ( 4.2A)
None
 1.39A 1ee2A-4uybA:
undetectable		 1ee2A-4uybA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 4uyb SEC14-LIKE PROTEIN 3
(Homo
sapiens) 		5 / 11 CYH A 254
LEU A 190
LEU A 237
CYH A  89
ILE A 152
 EDO  A1403 ( 3.8A)
None
None
EDO  A1403 ( 4.2A)
None
 1.39A 1ee2B-4uybA:
undetectable		 1ee2B-4uybA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 4uyb SEC14-LIKE PROTEIN 3
(Homo
sapiens) 		5 / 12 GLY A 201
ALA A 194
PHE A 163
LEU A 160
ASN A 203
 UNL  A1407 ( 3.2A)
None
None
None
None
 1.13A 1nw3A-4uybA:
undetectable		 1nw3A-4uybA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 4uyb SEC14-LIKE PROTEIN 3
(Homo
sapiens) 		4 / 8 LEU A 209
GLU A 211
ILE A 217
TYR A 202
 None
 1.10A 1qvtA-4uybA:
undetectable		 1qvtA-4uybA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BL9_A_CP6A1240_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4uyb SEC14-LIKE PROTEIN 3
(Homo
sapiens) 		5 / 12 ILE A 217
MET A 205
ILE A 103
ILE A 191
THR A 213
 None
UNL  A1407 ( 4.9A)
UNL  A1407 ( 4.6A)
None
None
 1.09A 2bl9A-4uybA:
undetectable		 2bl9A-4uybA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_A_BEZA1222_0
(PEROXIREDOXIN 6)		 4uyb SEC14-LIKE PROTEIN 3
(Homo
sapiens) 		4 / 7 THR A 398
PRO A 399
VAL A 400
GLU A 156
 None
None
None
EDO  A1401 ( 4.4A)
 0.97A 2v2gA-4uybA:
undetectable
2v2gB-4uybA:
undetectable		 2v2gA-4uybA:
19.55
2v2gB-4uybA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_B_BEZB1220_0
(PEROXIREDOXIN 6)		 4uyb SEC14-LIKE PROTEIN 3
(Homo
sapiens) 		4 / 7 THR A 398
PRO A 399
VAL A 400
GLU A 156
 None
None
None
EDO  A1401 ( 4.4A)
 0.95A 2v2gA-4uybA:
undetectable
2v2gB-4uybA:
undetectable		 2v2gA-4uybA:
19.55
2v2gB-4uybA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_C_BEZC1222_0
(PEROXIREDOXIN 6)		 4uyb SEC14-LIKE PROTEIN 3
(Homo
sapiens) 		4 / 7 THR A 398
PRO A 399
VAL A 400
GLU A 156
 None
None
None
EDO  A1401 ( 4.4A)
 0.97A 2v2gC-4uybA:
undetectable
2v2gD-4uybA:
undetectable		 2v2gC-4uybA:
19.55
2v2gD-4uybA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_D_BEZD1221_0
(PEROXIREDOXIN 6)		 4uyb SEC14-LIKE PROTEIN 3
(Homo
sapiens) 		4 / 7 THR A 398
PRO A 399
VAL A 400
GLU A 156
 None
None
None
EDO  A1401 ( 4.4A)
 0.97A 2v2gC-4uybA:
undetectable
2v2gD-4uybA:
undetectable		 2v2gC-4uybA:
19.55
2v2gD-4uybA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_A_BEZA1222_0
(PEROXIREDOXIN 6)		 4uyb SEC14-LIKE PROTEIN 3
(Homo
sapiens) 		4 / 8 THR A 398
PRO A 399
VAL A 400
GLU A 156
 None
None
None
EDO  A1401 ( 4.4A)
 0.94A 2v32A-4uybA:
undetectable
2v32B-4uybA:
undetectable		 2v32A-4uybA:
19.55
2v32B-4uybA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_B_BEZB1220_0
(PEROXIREDOXIN 6)		 4uyb SEC14-LIKE PROTEIN 3
(Homo
sapiens) 		4 / 8 THR A 398
PRO A 399
VAL A 400
GLU A 156
 None
None
None
EDO  A1401 ( 4.4A)
 0.95A 2v32A-4uybA:
undetectable
2v32B-4uybA:
undetectable		 2v32A-4uybA:
19.55
2v32B-4uybA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_C_BEZC1222_0
(PEROXIREDOXIN 6)		 4uyb SEC14-LIKE PROTEIN 3
(Homo
sapiens) 		4 / 8 THR A 398
PRO A 399
VAL A 400
GLU A 156
 None
None
None
EDO  A1401 ( 4.4A)
 0.98A 2v32C-4uybA:
undetectable
2v32D-4uybA:
undetectable		 2v32C-4uybA:
19.55
2v32D-4uybA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_D_BEZD1221_0
(PEROXIREDOXIN 6)		 4uyb SEC14-LIKE PROTEIN 3
(Homo
sapiens) 		4 / 8 THR A 398
PRO A 399
VAL A 400
GLU A 156
 None
None
None
EDO  A1401 ( 4.4A)
 0.98A 2v32C-4uybA:
undetectable
2v32D-4uybA:
undetectable		 2v32C-4uybA:
19.55
2v32D-4uybA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_C_BEZC1218_0
(PEROXIREDOXIN 6.)		 4uyb SEC14-LIKE PROTEIN 3
(Homo
sapiens) 		4 / 8 THR A 398
PRO A 399
VAL A 400
GLU A 156
 None
None
None
EDO  A1401 ( 4.4A)
 0.99A 2v41C-4uybA:
undetectable
2v41D-4uybA:
undetectable		 2v41C-4uybA:
19.55
2v41D-4uybA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_D_BEZD1222_0
(PEROXIREDOXIN 6.)		 4uyb SEC14-LIKE PROTEIN 3
(Homo
sapiens) 		4 / 8 THR A 398
PRO A 399
VAL A 400
GLU A 156
 None
None
None
EDO  A1401 ( 4.4A)
 1.03A 2v41C-4uybA:
undetectable
2v41D-4uybA:
undetectable		 2v41C-4uybA:
19.55
2v41D-4uybA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_E_BEZE1222_0
(PEROXIREDOXIN 6.)		 4uyb SEC14-LIKE PROTEIN 3
(Homo
sapiens) 		4 / 7 THR A 398
PRO A 399
VAL A 400
GLU A 156
 None
None
None
EDO  A1401 ( 4.4A)
 0.93A 2v41E-4uybA:
undetectable
2v41F-4uybA:
undetectable		 2v41E-4uybA:
19.55
2v41F-4uybA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_F_BEZF1222_0
(PEROXIREDOXIN 6.)		 4uyb SEC14-LIKE PROTEIN 3
(Homo
sapiens) 		4 / 7 THR A 398
PRO A 399
VAL A 400
GLU A 156
 None
None
None
EDO  A1401 ( 4.4A)
 1.05A 2v41E-4uybA:
undetectable
2v41F-4uybA:
undetectable		 2v41E-4uybA:
19.55
2v41F-4uybA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_G_BEZG1222_0
(PEROXIREDOXIN 6.)		 4uyb SEC14-LIKE PROTEIN 3
(Homo
sapiens) 		4 / 8 THR A 398
PRO A 399
VAL A 400
GLU A 156
 None
None
None
EDO  A1401 ( 4.4A)
 0.96A 2v41G-4uybA:
undetectable
2v41H-4uybA:
undetectable		 2v41G-4uybA:
19.55
2v41H-4uybA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_1
(UNCHARACTERIZED
PROTEIN PH0793)		 4uyb SEC14-LIKE PROTEIN 3
(Homo
sapiens) 		3 / 3 MET A  60
GLU A 129
ASP A 136
 None
 1.03A 3a25A-4uybA:
undetectable		 3a25A-4uybA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 4uyb SEC14-LIKE PROTEIN 3
(Homo
sapiens) 		4 / 8 TYR A 294
GLU A 293
PHE A 316
ILE A 314
 None
 1.07A 3jz0B-4uybA:
undetectable		 3jz0B-4uybA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_I_ACHI323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 4uyb SEC14-LIKE PROTEIN 3
(Homo
sapiens) 		4 / 8 TYR A  59
ILE A  68
GLU A 129
TYR A 182
 None
 1.06A 3rqwI-4uybA:
undetectable
3rqwJ-4uybA:
undetectable		 3rqwI-4uybA:
21.95
3rqwJ-4uybA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_C_BEZC1_0
(HEME-BINDING PROTEIN
HUTZ)		 4uyb SEC14-LIKE PROTEIN 3
(Homo
sapiens) 		4 / 5 TYR A 100
PHE A 241
PRO A 238
LEU A 228
 None
 1.41A 3tgvC-4uybA:
undetectable		 3tgvC-4uybA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 4uyb SEC14-LIKE PROTEIN 3
(Homo
sapiens) 		5 / 11 CYH A 155
LEU A 220
ILE A 218
LEU A 231
LEU A 237
 UNL  A1407 ( 4.2A)
None
None
None
None
 1.18A 4dm8A-4uybA:
undetectable		 4dm8A-4uybA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZGF_A_BEZA210_0
(UNCHARACTERIZED
PROTEIN)		 4uyb SEC14-LIKE PROTEIN 3
(Homo
sapiens) 		4 / 4 VAL A 372
ALA A 374
ASN A 285
GLN A 283
 None
None
EDO  A1406 (-4.8A)
None
 1.48A 4zgfA-4uybA:
undetectable		 4zgfA-4uybA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4uyb SEC14-LIKE PROTEIN 3
(Homo
sapiens) 		4 / 8 TYR A 260
CYH A  89
TYR A 100
LEU A 245
 None
EDO  A1403 ( 4.2A)
None
EDO  A1403 ( 4.2A)
 1.29A 5kxiA-4uybA:
2.5
5kxiB-4uybA:
2.5		 5kxiA-4uybA:
21.28
5kxiB-4uybA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4uyb SEC14-LIKE PROTEIN 3
(Homo
sapiens) 		4 / 8 TYR A 260
CYH A  89
TYR A 100
LEU A 245
 None
EDO  A1403 ( 4.2A)
None
EDO  A1403 ( 4.2A)
 1.37A 5kxiD-4uybA:
2.5
5kxiE-4uybA:
2.4		 5kxiD-4uybA:
21.28
5kxiE-4uybA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_ACTA405_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4uyb SEC14-LIKE PROTEIN 3
(Homo
sapiens) 		4 / 6 THR A 123
ARG A 126
GLN A  75
ILE A  80
 None
 1.36A 6ef6A-4uybA:
undetectable		 6ef6A-4uybA:
21.45