SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uyr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 4uyr FLOCCULATION PROTEIN
FLO11
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 113
TYR A 118
LEU A  93
LEU A 110
ILE A 120
 None
 1.31A 1fmlA-4uyrA:
undetectable		 1fmlA-4uyrA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 4uyr FLOCCULATION PROTEIN
FLO11
(Saccharomyces
cerevisiae) 		4 / 6 LEU A  90
THR A 171
TYR A 154
TYR A 113
 None
 1.34A 1qvuA-4uyrA:
undetectable		 1qvuA-4uyrA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 4uyr FLOCCULATION PROTEIN
FLO11
(Saccharomyces
cerevisiae) 		3 / 3 HIS A   5
GLU A  33
HIS A   8
 None
None
PO4  A1210 (-3.8A)
 0.80A 3ba0A-4uyrA:
undetectable		 3ba0A-4uyrA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD392_1
(TETX2 PROTEIN)		 4uyr FLOCCULATION PROTEIN
FLO11
(Saccharomyces
cerevisiae) 		4 / 5 HIS A   7
SER A  69
SER A  67
VAL A  68
 PO4  A1210 ( 4.0A)
MG  A1209 (-3.0A)
None
None
 1.47A 4a99D-4uyrA:
undetectable		 4a99D-4uyrA:
25.28