SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uz1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_A_DVAA8_0
(ACTINOMYCIN D)		 4uz1 NOTUM
(Homo
sapiens) 		3 / 3 THR A 284
THR A 282
PRO A 287
 None
 0.79A 1a7yA-4uz1A:
undetectable		 1a7yA-4uz1A:
2.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB8_0
(ACTINOMYCIN D)		 4uz1 NOTUM
(Homo
sapiens) 		3 / 3 THR A 284
THR A 282
PRO A 287
 None
 0.85A 1a7yB-4uz1A:
undetectable		 1a7yB-4uz1A:
2.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 4uz1 NOTUM
(Homo
sapiens) 		4 / 7 GLY A 235
ASP A 340
HIS A 389
ALA A 342
 None
 0.96A 1gxsA-4uz1A:
6.0
1gxsB-4uz1A:
undetectable		 1gxsA-4uz1A:
20.97
1gxsB-4uz1A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_1
(HIV-II PROTEASE)		 4uz1 NOTUM
(Homo
sapiens) 		5 / 12 ALA A 229
ILE A 393
GLY A 234
ILE A 391
ILE A 392
 None
 0.93A 1hshC-4uz1A:
undetectable		 1hshC-4uz1A:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE2_0
(ACTINOMYCIN D)		 4uz1 NOTUM
(Homo
sapiens) 		3 / 3 THR A 282
PRO A 287
THR A 284
 None
 0.81A 1i3wE-4uz1A:
undetectable		 1i3wE-4uz1A:
2.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE8_0
(ACTINOMYCIN D)		 4uz1 NOTUM
(Homo
sapiens) 		3 / 3 THR A 284
THR A 282
PRO A 287
 None
 0.87A 1i3wE-4uz1A:
undetectable		 1i3wE-4uz1A:
2.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_F_DVAF8_0
(ACTINOMYCIN D)		 4uz1 NOTUM
(Homo
sapiens) 		3 / 3 THR A 284
THR A 282
PRO A 287
 None
 0.82A 1i3wF-4uz1A:
undetectable		 1i3wF-4uz1A:
2.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG2_0
(ACTINOMYCIN D)		 4uz1 NOTUM
(Homo
sapiens) 		3 / 3 THR A 282
PRO A 287
THR A 284
 None
 0.85A 1i3wG-4uz1A:
undetectable		 1i3wG-4uz1A:
2.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_H_DVAH8_0
(ACTINOMYCIN D)		 4uz1 NOTUM
(Homo
sapiens) 		3 / 3 THR A 284
THR A 282
PRO A 287
 None
 0.86A 1i3wH-4uz1A:
undetectable		 1i3wH-4uz1A:
2.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD8_0
(ACTINOMYCIN D)		 4uz1 NOTUM
(Homo
sapiens) 		3 / 3 THR A 284
THR A 282
PRO A 287
 None
 0.82A 1mnvD-4uz1A:
undetectable		 1mnvD-4uz1A:
2.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OVF_B_DVAB2_0
(ACTINOMYCIN D)		 4uz1 NOTUM
(Homo
sapiens) 		3 / 3 THR A 282
PRO A 287
THR A 284
 None
 0.79A 1ovfB-4uz1A:
undetectable		 1ovfB-4uz1A:
2.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_A_DVAA8_0
(ACTINOMYCIN X2)		 4uz1 NOTUM
(Homo
sapiens) 		3 / 3 THR A 284
THR A 282
PRO A 287
 None
 0.81A 1qfiA-4uz1A:
undetectable		 1qfiA-4uz1A:
2.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_B_DVAB8_0
(ACTINOMYCIN X2)		 4uz1 NOTUM
(Homo
sapiens) 		3 / 3 THR A 284
THR A 282
PRO A 287
 None
 0.84A 1qfiB-4uz1A:
undetectable		 1qfiB-4uz1A:
2.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)		 4uz1 NOTUM
(Homo
sapiens) 		4 / 6 PRO A 384
PHE A 123
ILE A 391
SER A 231
 None
 1.18A 1sbrA-4uz1A:
undetectable
1sbrB-4uz1A:
undetectable		 1sbrA-4uz1A:
19.73
1sbrB-4uz1A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4uz1 NOTUM
(Homo
sapiens) 		5 / 12 ALA A 290
ILE A 291
ILE A 283
ALA A 342
PHE A 320
 None
 0.99A 1uduB-4uz1A:
undetectable		 1uduB-4uz1A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF8_0
(7-AMINO-ACTINOMYCIN
D)		 4uz1 NOTUM
(Homo
sapiens) 		3 / 3 THR A 284
THR A 282
PRO A 287
 None
 0.80A 1unjF-4uz1A:
undetectable		 1unjF-4uz1A:
2.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL2_0
(7-AMINO-ACTINOMYCIN
D)		 4uz1 NOTUM
(Homo
sapiens) 		3 / 3 THR A 282
PRO A 287
THR A 284
 None
 0.85A 1unjL-4uz1A:
undetectable		 1unjL-4uz1A:
2.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL8_0
(7-AMINO-ACTINOMYCIN
D)		 4uz1 NOTUM
(Homo
sapiens) 		3 / 3 THR A 284
THR A 282
PRO A 287
 None
 0.85A 1unjL-4uz1A:
undetectable		 1unjL-4uz1A:
2.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR8_0
(7-AMINO-ACTINOMYCIN
D)		 4uz1 NOTUM
(Homo
sapiens) 		3 / 3 THR A 284
THR A 282
PRO A 287
 None
 0.84A 1unjR-4uz1A:
undetectable		 1unjR-4uz1A:
2.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX2_0
(7-AMINO-ACTINOMYCIN
D)		 4uz1 NOTUM
(Homo
sapiens) 		3 / 3 THR A 282
PRO A 287
THR A 284
 None
 0.87A 1unjX-4uz1A:
undetectable		 1unjX-4uz1A:
2.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX8_0
(7-AMINO-ACTINOMYCIN
D)		 4uz1 NOTUM
(Homo
sapiens) 		3 / 3 THR A 284
THR A 282
PRO A 287
 None
 0.82A 1unjX-4uz1A:
undetectable		 1unjX-4uz1A:
2.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE8_0
(7-AMINOACTINOMYCIN D)		 4uz1 NOTUM
(Homo
sapiens) 		3 / 3 THR A 284
THR A 282
PRO A 287
 None
 0.85A 1unmE-4uz1A:
undetectable		 1unmE-4uz1A:
2.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF2_0
(7-AMINOACTINOMYCIN D)		 4uz1 NOTUM
(Homo
sapiens) 		3 / 3 THR A 282
PRO A 287
THR A 284
 None
 0.87A 1unmF-4uz1A:
undetectable		 1unmF-4uz1A:
2.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 4uz1 NOTUM
(Homo
sapiens) 		5 / 10 ILE A 161
LEU A 121
ASN A 176
ASN A 169
VAL A 225
 None
 1.13A 2nnhB-4uz1A:
undetectable		 2nnhB-4uz1A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 4uz1 NOTUM
(Homo
sapiens) 		5 / 12 ALA A 229
GLY A 261
LEU A 122
PHE A 333
LEU A 162
 None
 1.35A 3bxoA-4uz1A:
undetectable		 3bxoA-4uz1A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_2
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 4uz1 NOTUM
(Homo
sapiens) 		4 / 6 ASN A 317
TRP A 316
TYR A 129
TRP A 128
 None
 1.43A 3jzjA-4uz1A:
0.0		 3jzjA-4uz1A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4uz1 NOTUM
(Homo
sapiens) 		4 / 5 ILE A 364
PHE A 339
ASP A 340
GLU A 341
 None
 1.12A 3kp6A-4uz1A:
undetectable
3kp6B-4uz1A:
undetectable		 3kp6A-4uz1A:
18.16
3kp6B-4uz1A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4uz1 NOTUM
(Homo
sapiens) 		6 / 12 GLY A 266
ASP A 264
VAL A 334
GLY A 321
ALA A 233
GLY A 234
 None
 1.31A 3ku1C-4uz1A:
undetectable		 3ku1C-4uz1A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4uz1 NOTUM
(Homo
sapiens) 		5 / 12 LEU A 375
GLY A 266
GLY A 234
GLY A 321
LEU A 240
 None
 1.15A 3ku1G-4uz1A:
undetectable		 3ku1G-4uz1A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 4uz1 NOTUM
(Homo
sapiens) 		4 / 8 VAL A 238
GLY A 230
ILE A 161
GLY A 261
 None
 0.80A 3n9jB-4uz1A:
undetectable		 3n9jB-4uz1A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_1
(PROTEASE)		 4uz1 NOTUM
(Homo
sapiens) 		5 / 9 ALA A 229
ILE A 393
GLY A 126
ILE A 391
ILE A 392
 None
 0.97A 3s45A-4uz1A:
undetectable		 3s45A-4uz1A:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_1
(PROTEASE)		 4uz1 NOTUM
(Homo
sapiens) 		5 / 9 ALA A 229
ILE A 393
GLY A 234
ILE A 391
ILE A 392
 None
 1.01A 3s45A-4uz1A:
undetectable		 3s45A-4uz1A:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC610_0
(GBAA_1210 PROTEIN)		 4uz1 NOTUM
(Homo
sapiens) 		3 / 3 ASN A 241
ALA A 205
ARG A 244
 None
None
SO4  A1456 (-4.0A)
 0.85A 3tj7C-4uz1A:
undetectable
3tj7D-4uz1A:
undetectable		 3tj7C-4uz1A:
21.26
3tj7D-4uz1A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 4uz1 NOTUM
(Homo
sapiens) 		5 / 12 LEU A 240
THR A 288
ILE A 291
ALA A 263
VAL A 346
 None
 1.15A 3vw1D-4uz1A:
undetectable		 3vw1D-4uz1A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 4uz1 NOTUM
(Homo
sapiens) 		4 / 5 ARG A 118
GLY A 222
ALA A 223
GLY A 219
 None
 0.94A 4u9uA-4uz1A:
undetectable		 4u9uA-4uz1A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIL_H_QI9H1223_0
(FAB 314.1)		 4uz1 NOTUM
(Homo
sapiens) 		5 / 12 TRP A 128
HIS A 389
ALA A 342
GLY A 127
GLY A 230
 None
 0.89A 4uilH-4uz1A:
undetectable
4uilL-4uz1A:
undetectable		 4uilH-4uz1A:
21.60
4uilL-4uz1A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4uz1 NOTUM
(Homo
sapiens) 		4 / 5 PHE A 179
LEU A 146
GLY A 127
ILE A 393
 None
 1.02A 5ik1A-4uz1A:
undetectable		 5ik1A-4uz1A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4uz1 NOTUM
(Homo
sapiens) 		4 / 4 LEU A  89
GLY A 158
SER A 163
SER A 164
 None
 1.26A 5uunA-4uz1A:
undetectable		 5uunA-4uz1A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB306_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4uz1 NOTUM
(Homo
sapiens) 		4 / 4 LEU A  89
GLY A 158
SER A 163
SER A 164
 None
 1.34A 5uunB-4uz1A:
undetectable		 5uunB-4uz1A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NQA_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4uz1 NOTUM
(Homo
sapiens) 		5 / 10 THR A 236
GLY A 127
GLY A 126
VAL A 187
GLU A 125
 None
 1.38A 6nqaK-4uz1A:
undetectable		 6nqaK-4uz1A:
19.68