SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uzg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_ACTA1181_0
(WNT INHIBITORY
FACTOR 1)
4uzg SURFACE PROTEIN SPB1
(Streptococcus
agalactiae)
3 / 3 TYR A 194
VAL A 189
THR A 199
None
0.51A 2ygnA-4uzgA:
undetectable
2ygnA-4uzgA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)
4uzg SURFACE PROTEIN SPB1
(Streptococcus
agalactiae)
5 / 12 ALA A 318
LEU A 325
GLU A 416
ASN A 453
LEU A 441
None
1.34A 3eigA-4uzgA:
undetectable
3eigA-4uzgA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)
4uzg SURFACE PROTEIN SPB1
(Streptococcus
agalactiae)
4 / 8 PHE A 384
THR A 410
GLY A 352
SER A 195
EDO  A1472 ( 4.8A)
EDO  A1472 (-4.7A)
None
None
1.09A 3tzfB-4uzgA:
undetectable
3tzfB-4uzgA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)
4uzg SURFACE PROTEIN SPB1
(Streptococcus
agalactiae)
5 / 12 PRO A 458
LEU A 421
ILE A 409
ILE A 354
PHE A 384
None
None
None
None
EDO  A1472 ( 4.8A)
1.36A 4a79A-4uzgA:
undetectable
4a79A-4uzgA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)
4uzg SURFACE PROTEIN SPB1
(Streptococcus
agalactiae)
5 / 12 PRO A 458
LEU A 421
ILE A 409
ILE A 354
PHE A 384
None
None
None
None
EDO  A1472 ( 4.8A)
1.40A 4a79B-4uzgA:
undetectable
4a79B-4uzgA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
4uzg SURFACE PROTEIN SPB1
(Streptococcus
agalactiae)
4 / 4 GLY A 352
LEU A 421
PHE A 372
ILE A 356
None
0.90A 4xv2A-4uzgA:
undetectable
4xv2A-4uzgA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_A_1FLA1375_1
(DNA POLYMERASE III
SUBUNIT BETA)
4uzg SURFACE PROTEIN SPB1
(Streptococcus
agalactiae)
4 / 8 THR A 418
LEU A 441
ILE A 354
LEU A 414
EDO  A1471 (-4.7A)
None
None
None
0.93A 5g48A-4uzgA:
undetectable
5g48A-4uzgA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NQA_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)
4uzg SURFACE PROTEIN SPB1
(Streptococcus
agalactiae)
5 / 10 THR A 446
GLY A 417
GLY A 442
VAL A 456
GLU A 416
None
EDO  A1471 (-3.2A)
None
None
None
0.96A 6nqaK-4uzgA:
undetectable
6nqaK-4uzgA:
19.62