SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uzj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 4uzj NOTUM
(Drosophila
melanogaster) 		5 / 12 GLY A 235
GLY A 239
GLY A 242
SER A 268
PHE A 273
 None
 0.98A 1dx6A-4uzjA:
10.1		 1dx6A-4uzjA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4uzj NOTUM
(Drosophila
melanogaster) 		4 / 8 PRO A 616
SER A 270
PHE A 333
ASP A 391
 None
 1.21A 1p7lD-4uzjA:
undetectable		 1p7lD-4uzjA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4uzj NOTUM
(Drosophila
melanogaster) 		4 / 8 PRO A 616
SER A 270
PHE A 333
ASP A 391
 None
 1.21A 1rg9B-4uzjA:
undetectable		 1rg9B-4uzjA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)		 4uzj NOTUM
(Drosophila
melanogaster) 		4 / 6 GLY A 125
SER A 237
LEU A 145
HIS A 384
 None
 0.94A 1yajF-4uzjA:
10.2		 1yajF-4uzjA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P02_A_SAMA2_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-2)		 4uzj NOTUM
(Drosophila
melanogaster) 		4 / 8 PRO A 616
SER A 270
PHE A 333
ASP A 391
 None
 1.22A 2p02A-4uzjA:
undetectable		 2p02A-4uzjA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		 4uzj NOTUM
(Drosophila
melanogaster) 		5 / 12 SER A 268
GLY A 242
GLY A 240
GLN A 334
GLY A 125
 None
 0.94A 2pkkA-4uzjA:
undetectable		 2pkkA-4uzjA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKM_A_ADNA501_1
(ADENOSINE KINASE)		 4uzj NOTUM
(Drosophila
melanogaster) 		5 / 12 SER A 268
GLY A 242
GLY A 240
GLN A 334
GLY A 125
 None
 0.94A 2pkmA-4uzjA:
undetectable		 2pkmA-4uzjA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 4uzj NOTUM
(Drosophila
melanogaster) 		4 / 6 PHE A 273
TRP A 127
GLY A 239
GLY A 240
 None
 0.96A 2qr2A-4uzjA:
3.2
2qr2B-4uzjA:
undetectable		 2qr2A-4uzjA:
20.70
2qr2B-4uzjA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 4uzj NOTUM
(Drosophila
melanogaster) 		4 / 6 PHE A 273
TRP A 127
GLY A 239
GLY A 242
 None
 0.86A 2qr2A-4uzjA:
3.2
2qr2B-4uzjA:
undetectable		 2qr2A-4uzjA:
20.70
2qr2B-4uzjA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 4uzj NOTUM
(Drosophila
melanogaster) 		4 / 5 TRP A 127
GLY A 239
GLY A 240
PHE A 273
 None
 0.93A 2qr2A-4uzjA:
3.3
2qr2B-4uzjA:
undetectable		 2qr2A-4uzjA:
20.70
2qr2B-4uzjA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 4uzj NOTUM
(Drosophila
melanogaster) 		4 / 5 TRP A 127
GLY A 239
GLY A 242
PHE A 273
 None
 0.85A 2qr2A-4uzjA:
3.3
2qr2B-4uzjA:
undetectable		 2qr2A-4uzjA:
20.70
2qr2B-4uzjA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4uzj NOTUM
(Drosophila
melanogaster) 		4 / 7 TYR A 317
GLY A 239
ALA A 238
MET A 241
 None
 0.89A 2wekB-4uzjA:
2.6		 2wekB-4uzjA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCZ_A_SAMA4633_0
(POLYPROTEIN)		 4uzj NOTUM
(Drosophila
melanogaster) 		5 / 12 GLY A 242
GLY A 271
GLY A 239
ASP A 345
VAL A 344
 None
 1.03A 3gczA-4uzjA:
undetectable		 3gczA-4uzjA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 4uzj NOTUM
(Drosophila
melanogaster) 		4 / 8 VAL A 243
GLY A 235
ILE A 160
GLY A 266
 None
 0.73A 3n9jB-4uzjA:
undetectable		 3n9jB-4uzjA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_C_SAMC263_0
(NON-STRUCTURAL
PROTEIN 5)		 4uzj NOTUM
(Drosophila
melanogaster) 		5 / 12 GLY A 242
GLY A 271
GLY A 239
ASP A 345
VAL A 344
 None
 0.89A 3p97C-4uzjA:
undetectable		 3p97C-4uzjA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 4uzj NOTUM
(Drosophila
melanogaster) 		5 / 12 SER A 186
PHE A 273
GLY A 271
GLY A 319
GLY A 240
 None
 1.03A 3tegA-4uzjA:
undetectable		 3tegA-4uzjA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 4uzj NOTUM
(Drosophila
melanogaster) 		3 / 3 PHE A 388
SER A 270
SER A 237
 None
 0.84A 3ufgB-4uzjA:
undetectable		 3ufgB-4uzjA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4uzj NOTUM
(Drosophila
melanogaster) 		3 / 3 ASN A 175
TRP A 119
ASP A  84
 None
 1.12A 4a7tA-4uzjA:
undetectable
4a7tF-4uzjA:
undetectable		 4a7tA-4uzjA:
15.89
4a7tF-4uzjA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4uzj NOTUM
(Drosophila
melanogaster) 		4 / 8 PRO A 616
SER A 270
PHE A 333
ASP A 391
 None
 1.20A 4kttA-4uzjA:
undetectable		 4kttA-4uzjA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4uzj NOTUM
(Drosophila
melanogaster) 		4 / 8 PRO A 616
SER A 270
PHE A 333
ASP A 391
 None
 1.21A 4kttC-4uzjA:
undetectable		 4kttC-4uzjA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4uzj NOTUM
(Drosophila
melanogaster) 		4 / 8 PRO A 616
SER A 270
PHE A 333
ASP A 391
 None
 1.15A 4ndnA-4uzjA:
undetectable		 4ndnA-4uzjA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4uzj NOTUM
(Drosophila
melanogaster) 		4 / 5 GLY A 235
LEU A 231
LEU A 211
LEU A  88
 None
 0.85A 4o8fA-4uzjA:
undetectable		 4o8fA-4uzjA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_C_SAMC4000_0
(GENOME POLYPROTEIN)		 4uzj NOTUM
(Drosophila
melanogaster) 		5 / 12 GLY A 242
GLY A 271
GLY A 239
ASP A 345
VAL A 344
 None
 0.85A 5e9qC-4uzjA:
undetectable		 5e9qC-4uzjA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_C_SAMC4000_0
(GENOME POLYPROTEIN)		 4uzj NOTUM
(Drosophila
melanogaster) 		5 / 12 GLY A 242
GLY A 271
GLY A 239
ASP A 345
VAL A 344
 None
 0.89A 5eifC-4uzjA:
undetectable		 5eifC-4uzjA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQR_A_SAMA301_0
(METHYLTRANSFERASE)		 4uzj NOTUM
(Drosophila
melanogaster) 		5 / 12 GLY A 242
GLY A 271
GLY A 239
ASP A 345
VAL A 344
 None
 0.95A 5kqrA-4uzjA:
undetectable		 5kqrA-4uzjA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4uzj NOTUM
(Drosophila
melanogaster) 		4 / 8 PRO A 616
SER A 270
PHE A 333
ASP A 391
 None
 1.20A 5t8sB-4uzjA:
undetectable		 5t8sB-4uzjA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 4uzj NOTUM
(Drosophila
melanogaster) 		5 / 12 LEU A 387
LEU A 370
VAL A 373
PHE A 273
GLY A 125
 None
 1.07A 5uxdB-4uzjA:
undetectable		 5uxdB-4uzjA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_B_SAMB601_0
(NS5
METHYLTRANSFERASE)		 4uzj NOTUM
(Drosophila
melanogaster) 		5 / 12 GLY A 242
GLY A 271
GLY A 239
ASP A 345
VAL A 344
 None
 0.90A 5wz1B-4uzjA:
undetectable		 5wz1B-4uzjA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_A_SAMA601_0
(NS5 MTASE)		 4uzj NOTUM
(Drosophila
melanogaster) 		5 / 12 GLY A 242
GLY A 271
GLY A 239
ASP A 345
VAL A 344
 None
 0.91A 5wz2A-4uzjA:
undetectable		 5wz2A-4uzjA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4uzj NOTUM
(Drosophila
melanogaster) 		3 / 3 ARG A 601
PHE A 333
LEU A 370
 None
 0.94A 5x1bC-4uzjA:
undetectable		 5x1bC-4uzjA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4uzj NOTUM
(Drosophila
melanogaster) 		4 / 8 PRO A 616
SER A 270
PHE A 333
ASP A 391
 None
 1.18A 6fbnB-4uzjA:
undetectable		 6fbnB-4uzjA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBO_A_ADNA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4uzj NOTUM
(Drosophila
melanogaster) 		4 / 8 PRO A 616
SER A 270
PHE A 333
ASP A 391
 None
 1.20A 6fboA-4uzjA:
undetectable		 6fboA-4uzjA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4uzj NOTUM
(Drosophila
melanogaster) 		4 / 7 ILE A 215
LEU A 218
ARG A 251
THR A 263
 None
 0.89A 6nmfA-4uzjA:
undetectable
6nmfJ-4uzjA:
undetectable		 6nmfA-4uzjA:
19.47
6nmfJ-4uzjA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4uzj NOTUM
(Drosophila
melanogaster) 		4 / 7 ILE A 215
LEU A 218
ARG A 251
THR A 263
 None
 0.93A 6nmpA-4uzjA:
undetectable
6nmpJ-4uzjA:
undetectable		 6nmpA-4uzjA:
19.47
6nmpJ-4uzjA:
9.86