SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uzr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 4uzr PUTATIVE
UNCHARACTERIZED
PROTEIN PH1500
(Pyrococcus
horikoshii) 		5 / 11 GLY A  43
ILE A  44
SER A  45
ILE A  46
LEU A  19
 None
 0.86A 2kawA-4uzrA:
undetectable		 2kawA-4uzrA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 4uzr PUTATIVE
UNCHARACTERIZED
PROTEIN PH1500
(Pyrococcus
horikoshii) 		5 / 12 ILE A 109
ILE A 101
ILE A  88
LEU A  93
VAL A 135
 None
 1.01A 3fpjB-4uzrA:
undetectable		 3fpjB-4uzrA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4uzr PUTATIVE
UNCHARACTERIZED
PROTEIN PH1500
(Pyrococcus
horikoshii) 		4 / 4 GLY A  33
LEU A  11
PHE A  53
ILE A  27
 None
 0.89A 4xv2A-4uzrA:
undetectable		 4xv2A-4uzrA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4uzr PUTATIVE
UNCHARACTERIZED
PROTEIN PH1500
(Pyrococcus
horikoshii) 		4 / 4 LEU A 108
ILE A 109
GLY A 120
ILE A 146
 None
 0.87A 5dzk3-4uzrA:
undetectable
5dzkm-4uzrA:
undetectable		 5dzk3-4uzrA:
7.69
5dzkm-4uzrA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4uzr PUTATIVE
UNCHARACTERIZED
PROTEIN PH1500
(Pyrococcus
horikoshii) 		4 / 5 ILE A 109
GLY A 120
ILE A 146
LEU A 108
 None
 0.87A 5dzki-4uzrA:
undetectable
5dzkj-4uzrA:
undetectable
5dzkx-4uzrA:
undetectable		 5dzki-4uzrA:
20.79
5dzkj-4uzrA:
20.79
5dzkx-4uzrA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4uzr PUTATIVE
UNCHARACTERIZED
PROTEIN PH1500
(Pyrococcus
horikoshii) 		4 / 4 ILE A 109
GLY A 120
ILE A 146
LEU A 108
 None
 0.90A 5dzkl-4uzrA:
undetectable
5dzkz-4uzrA:
undetectable		 5dzkl-4uzrA:
20.79
5dzkz-4uzrA:
7.69