SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uzs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_4
(HIV-1 PROTEASE)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		4 / 4 GLY A 525
ASP A 522
GLY A 518
THR A 502
 POL  A 707 (-3.7A)
POL  A 707 ( 4.7A)
None
None
 1.01A 1hxbB-4uzsA:
undetectable		 1hxbB-4uzsA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		4 / 7 LEU A  89
VAL A  53
GLY A  54
ASP A  74
 None
None
None
P6G  A 705 ( 3.5A)
 0.42A 1p2yA-4uzsA:
undetectable		 1p2yA-4uzsA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		3 / 3 ASP A 353
LEU A  20
HIS A 644
 None
 0.72A 1qknA-4uzsA:
undetectable		 1qknA-4uzsA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		4 / 7 LEU A  89
VAL A  53
GLY A  54
ASP A  74
 None
None
None
P6G  A 705 ( 3.5A)
 0.35A 1t88A-4uzsA:
undetectable		 1t88A-4uzsA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		4 / 8 LEU A  89
VAL A  53
GLY A  54
ASP A  74
 None
None
None
P6G  A 705 ( 3.5A)
 0.44A 2a1oA-4uzsA:
undetectable		 2a1oA-4uzsA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		4 / 4 ASP A 387
ASP A 343
ASP A 394
GLY A 683
 None
 1.43A 2igtC-4uzsA:
undetectable		 2igtC-4uzsA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_B_SNLB2001_1
(MINERALOCORTICOID
RECEPTOR)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		5 / 12 LEU A 547
ASN A 549
LEU A 570
ALA A 615
LEU A 609
 None
 1.15A 2oaxB-4uzsA:
undetectable		 2oaxB-4uzsA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		5 / 11 GLY A 163
GLU A 123
ARG A 122
PHE A 263
THR A 261
 None
None
GOL  A 702 (-2.8A)
None
None
 1.28A 2vdvF-4uzsA:
undetectable		 2vdvF-4uzsA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		4 / 6 LEU A  80
ARG A 361
PRO A  28
VAL A 348
 None
 1.07A 2ygoA-4uzsA:
undetectable		 2ygoA-4uzsA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		4 / 8 LYS A 407
ARG A 688
ASP A 353
GLU A 314
 None
 1.33A 3dh0A-4uzsA:
undetectable		 3dh0A-4uzsA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		5 / 12 GLY A 392
GLY A  47
ASP A 387
VAL A 341
ARG A  19
 None
 1.36A 3dlcA-4uzsA:
undetectable		 3dlcA-4uzsA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		4 / 7 GLU A 320
ASP A  25
SER A 285
THR A 260
 GOL  A 702 (-2.7A)
None
None
None
 1.19A 3dzgB-4uzsA:
undetectable		 3dzgB-4uzsA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		3 / 3 SER A 462
ASP A 275
ASP A 456
 None
 0.82A 3iv6A-4uzsA:
undetectable		 3iv6A-4uzsA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		3 / 3 SER A 462
ASP A 275
ASP A 456
 None
 0.87A 3iv6C-4uzsA:
undetectable		 3iv6C-4uzsA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		5 / 11 ALA A  76
LEU A  89
VAL A  87
ASN A  27
ILE A  55
 None
 1.21A 3jw5A-4uzsA:
undetectable		 3jw5A-4uzsA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_2
(HIV-1 PROTEASE)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		4 / 4 GLY A 525
ASP A 522
GLY A 518
THR A 502
 POL  A 707 (-3.7A)
POL  A 707 ( 4.7A)
None
None
 0.99A 3k4vC-4uzsA:
undetectable		 3k4vC-4uzsA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		4 / 7 SER A 668
TYR A 357
LEU A 391
ASP A 387
 None
 1.41A 3lslA-4uzsA:
undetectable
3lslD-4uzsA:
undetectable		 3lslA-4uzsA:
17.57
3lslD-4uzsA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		4 / 7 PHE A 297
ILE A 665
THR A 408
ARG A 342
 None
 1.25A 3nxuA-4uzsA:
undetectable		 3nxuA-4uzsA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		3 / 3 THR A 561
SER A 562
ARG A 527
 None
POL  A 707 (-3.1A)
None
 0.83A 3phnA-4uzsA:
undetectable		 3phnA-4uzsA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		5 / 12 ILE A  77
LEU A  80
GLY A  54
ALA A  90
VAL A 153
 POL  A 706 ( 4.1A)
None
None
None
None
 0.88A 3rukB-4uzsA:
undetectable		 3rukB-4uzsA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		5 / 11 ALA A  76
VAL A  53
GLY A  81
ALA A  83
LEU A  89
 None
 1.01A 3sm2B-4uzsA:
undetectable		 3sm2B-4uzsA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_1
(HIV-1 PROTEASE)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		4 / 7 GLY A  47
ALA A  46
VAL A 375
ILE A  40
 None
 0.69A 3t3cA-4uzsA:
undetectable		 3t3cA-4uzsA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		3 / 3 LEU A  42
MET A 374
ASP A 387
 None
 0.86A 3v5wA-4uzsA:
undetectable		 3v5wA-4uzsA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_1
(METHYLTRANSFERASE
WBDD)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		3 / 3 ARG A 397
ASP A 387
GLN A 383
 None
 0.85A 4azsA-4uzsA:
undetectable		 4azsA-4uzsA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		4 / 6 PHE A 297
ALA A 301
ALA A 449
THR A 454
 None
 1.08A 4dtzB-4uzsA:
undetectable		 4dtzB-4uzsA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		4 / 6 PHE A 317
ALA A 354
GLY A  24
LEU A  50
 None
 0.76A 4dubA-4uzsA:
undetectable		 4dubA-4uzsA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		3 / 3 ARG A 233
TRP A 196
GLY A 226
 None
 0.85A 4e7cA-4uzsA:
1.0		 4e7cA-4uzsA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		3 / 3 PRO A 517
TYR A 599
GLY A 525
 None
None
POL  A 707 (-3.7A)
 0.68A 4g2zA-4uzsA:
undetectable		 4g2zA-4uzsA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		5 / 12 LEU A 613
PHE A 497
ALA A 589
MET A 620
GLY A 621
 None
 1.37A 4j7xA-4uzsA:
3.7		 4j7xA-4uzsA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_MTLA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		4 / 6 GLU A 106
ASP A 173
ASP A 172
ARG A 176
 None
 1.38A 4kcnA-4uzsA:
undetectable		 4kcnA-4uzsA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		5 / 12 ILE A  77
LEU A  80
GLY A  54
ALA A  90
VAL A 153
 POL  A 706 ( 4.1A)
None
None
None
None
 0.88A 4nkvB-4uzsA:
undetectable		 4nkvB-4uzsA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA207_0
(OXIDOREDUCTASE)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		4 / 4 GLU A 161
GLY A 163
HIS A 165
ARG A 122
 GOL  A 702 (-3.0A)
None
None
GOL  A 702 (-2.8A)
 1.28A 4r82A-4uzsA:
undetectable
4r82B-4uzsA:
undetectable		 4r82A-4uzsA:
15.46
4r82B-4uzsA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		4 / 5 ILE A 212
PRO A 213
TYR A 186
VAL A 192
 None
 1.30A 4s0vA-4uzsA:
3.8		 4s0vA-4uzsA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		3 / 3 ASP A 387
ARG A 334
PRO A 337
 None
 1.09A 4wanC-4uzsA:
undetectable		 4wanC-4uzsA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		5 / 12 GLY A 662
LEU A 398
ILE A 355
GLY A 351
THR A 408
 None
 1.06A 4ze2A-4uzsA:
undetectable		 4ze2A-4uzsA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		4 / 7 ARG A 487
SER A 483
GLY A 525
THR A 561
 None
None
POL  A 707 (-3.7A)
None
 0.98A 5btaA-4uzsA:
undetectable
5btaC-4uzsA:
undetectable
5btaD-4uzsA:
undetectable		 5btaA-4uzsA:
22.16
5btaC-4uzsA:
22.16
5btaD-4uzsA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		4 / 6 SER A 483
GLY A 525
THR A 561
ARG A 487
 None
POL  A 707 (-3.7A)
None
None
 0.96A 5btaA-4uzsA:
undetectable
5btaB-4uzsA:
undetectable
5btaC-4uzsA:
undetectable		 5btaA-4uzsA:
22.16
5btaB-4uzsA:
17.92
5btaC-4uzsA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		4 / 6 ARG A 487
SER A 483
GLY A 525
THR A 561
 None
None
POL  A 707 (-3.7A)
None
 0.88A 5btcA-4uzsA:
undetectable
5btcC-4uzsA:
undetectable
5btcD-4uzsA:
undetectable		 5btcA-4uzsA:
22.16
5btcC-4uzsA:
22.16
5btcD-4uzsA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		4 / 6 SER A 483
GLY A 525
THR A 561
ARG A 487
 None
POL  A 707 (-3.7A)
None
None
 0.91A 5btcA-4uzsA:
undetectable
5btcB-4uzsA:
undetectable
5btcC-4uzsA:
undetectable		 5btcA-4uzsA:
22.16
5btcB-4uzsA:
17.92
5btcC-4uzsA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		4 / 7 SER A 483
GLY A 525
THR A 561
ARG A 487
 None
POL  A 707 (-3.7A)
None
None
 0.92A 5btfA-4uzsA:
undetectable
5btfB-4uzsA:
undetectable
5btfC-4uzsA:
undetectable		 5btfA-4uzsA:
22.16
5btfB-4uzsA:
17.92
5btfC-4uzsA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_B_5D5B927_1
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		4 / 7 SER A 305
TYR A 302
HIS A 437
TYR A 467
 None
 1.16A 5dlvB-4uzsA:
undetectable		 5dlvB-4uzsA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		4 / 8 THR A 408
SER A 305
ALA A 301
THR A 454
 None
 0.92A 5eevL-4uzsA:
undetectable
5eevV-4uzsA:
undetectable		 5eevL-4uzsA:
6.82
5eevV-4uzsA:
6.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		4 / 8 THR A 408
SER A 305
ALA A 301
THR A 454
 None
 0.91A 5eewL-4uzsA:
undetectable
5eewV-4uzsA:
undetectable		 5eewL-4uzsA:
6.82
5eewV-4uzsA:
6.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		4 / 8 THR A 408
SER A 305
ALA A 301
THR A 454
 None
 0.92A 5ef3L-4uzsA:
undetectable
5ef3V-4uzsA:
undetectable		 5ef3L-4uzsA:
6.82
5ef3V-4uzsA:
6.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		5 / 12 GLY A 662
LEU A 398
ILE A 355
GLY A 351
THR A 408
 None
 1.13A 5eskA-4uzsA:
undetectable		 5eskA-4uzsA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		5 / 12 ASP A 353
ALA A 352
ASP A 456
GLY A 309
GLU A 314
 None
 1.15A 5hfjA-4uzsA:
undetectable		 5hfjA-4uzsA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		5 / 12 ASP A 353
ALA A 352
ASP A 456
GLY A 309
GLU A 314
 None
 1.21A 5hfjD-4uzsA:
undetectable		 5hfjD-4uzsA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN8_A_ACRA1016_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		4 / 5 ASP A 282
GLY A 256
PRO A 258
TRP A 156
 None
 0.93A 5nn8A-4uzsA:
2.7		 5nn8A-4uzsA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		5 / 10 LEU A 448
ILE A 453
GLY A 452
GLY A 629
SER A 612
 None
 1.14A 5twjB-4uzsA:
undetectable		 5twjB-4uzsA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		3 / 3 TYR A 501
ALA A 424
TYR A 476
 None
 0.87A 5uunB-4uzsA:
undetectable		 5uunB-4uzsA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA411_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		3 / 3 LYS A  45
LEU A  42
ARG A  41
 None
 0.76A 5yw0A-4uzsA:
undetectable		 5yw0A-4uzsA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		5 / 10 ASN A  27
GLU A 368
HIS A 371
GLU A 320
GLY A  24
 None
GOL  A 702 (-2.9A)
None
GOL  A 702 (-2.7A)
None
 1.11A 6bniA-4uzsA:
undetectable		 6bniA-4uzsA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		3 / 3 ARG A 176
ARG A 215
ARG A 126
 None
GOL  A 711 (-3.9A)
None
 0.99A 6bplA-4uzsA:
undetectable
6bplB-4uzsA:
undetectable		 6bplA-4uzsA:
8.12
6bplB-4uzsA:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		4 / 6 ASP A 555
TYR A 500
GLU A 440
ASP A 443
 None
 1.18A 6mn5A-4uzsA:
undetectable		 6mn5A-4uzsA:
8.29