SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uzu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 4uzu ALPHA-AMYLASE
(Geobacillus
stearothermophil
us) 		6 / 12 TYR A  57
LEU A 197
ASP A 232
ALA A 233
HIS A 328
ASP A 329
 None
None
NA  A1490 (-2.9A)
NA  A1490 ( 4.2A)
None
NA  A1490 ( 4.5A)
 0.71A 1dedA-4uzuA:
25.9		 1dedA-4uzuA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_B_QPSB1501_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 4uzu ALPHA-AMYLASE
(Geobacillus
stearothermophil
us) 		7 / 12 TYR A  57
ARG A 230
ASP A 232
ALA A 233
GLU A 262
HIS A 328
ASP A 329
 None
NA  A1490 ( 4.1A)
NA  A1490 (-2.9A)
NA  A1490 ( 4.2A)
NA  A1490 (-2.7A)
None
NA  A1490 ( 4.5A)
 0.69A 1dedB-4uzuA:
27.9		 1dedB-4uzuA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1502_0
(FERROCHELATASE)		 4uzu ALPHA-AMYLASE
(Geobacillus
stearothermophil
us) 		4 / 8 LEU A 202
PRO A  45
VAL A  59
GLY A  58
 None
 1.00A 1hrkA-4uzuA:
undetectable		 1hrkA-4uzuA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2502_0
(FERROCHELATASE)		 4uzu ALPHA-AMYLASE
(Geobacillus
stearothermophil
us) 		4 / 8 LEU A 202
PRO A  45
VAL A  59
GLY A  58
 None
 0.99A 1hrkB-4uzuA:
undetectable		 1hrkB-4uzuA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 4uzu ALPHA-AMYLASE
(Geobacillus
stearothermophil
us) 		5 / 12 TRP A  14
HIS A 106
ALA A 233
GLU A 262
ASP A 329
 None
None
NA  A1490 ( 4.2A)
NA  A1490 (-2.7A)
NA  A1490 ( 4.5A)
 0.69A 1kxhA-4uzuA:
28.6		 1kxhA-4uzuA:
24.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MXD_A_ACRA735_1
(ALPHA AMYLASE)		 4uzu ALPHA-AMYLASE
(Geobacillus
stearothermophil
us) 		8 / 12 TRP A  14
TYR A  57
ARG A 230
ASP A 232
GLU A 262
TRP A 264
HIS A 328
ASP A 329
 None
None
NA  A1490 ( 4.1A)
NA  A1490 (-2.9A)
NA  A1490 (-2.7A)
None
None
NA  A1490 ( 4.5A)
 0.91A 1mxdA-4uzuA:
39.5		 1mxdA-4uzuA:
30.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MXD_A_ACRA735_1
(ALPHA AMYLASE)		 4uzu ALPHA-AMYLASE
(Geobacillus
stearothermophil
us) 		8 / 12 TRP A  14
TYR A  57
HIS A 106
ARG A 230
ASP A 232
GLU A 262
HIS A 328
ASP A 329
 None
None
None
NA  A1490 ( 4.1A)
NA  A1490 (-2.9A)
NA  A1490 (-2.7A)
None
NA  A1490 ( 4.5A)
 0.36A 1mxdA-4uzuA:
39.5		 1mxdA-4uzuA:
30.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MXD_A_ACRA735_1
(ALPHA AMYLASE)		 4uzu ALPHA-AMYLASE
(Geobacillus
stearothermophil
us) 		8 / 12 TYR A  57
ARG A 230
ASP A 232
LYS A 235
GLU A 262
TRP A 264
HIS A 328
ASP A 329
 None
NA  A1490 ( 4.1A)
NA  A1490 (-2.9A)
None
NA  A1490 (-2.7A)
None
None
NA  A1490 ( 4.5A)
 1.00A 1mxdA-4uzuA:
39.5		 1mxdA-4uzuA:
30.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MXD_A_ACRA735_1
(ALPHA AMYLASE)		 4uzu ALPHA-AMYLASE
(Geobacillus
stearothermophil
us) 		8 / 12 TYR A  57
HIS A 106
ARG A 230
ASP A 232
LYS A 235
GLU A 262
HIS A 328
ASP A 329
 None
None
NA  A1490 ( 4.1A)
NA  A1490 (-2.9A)
None
NA  A1490 (-2.7A)
None
NA  A1490 ( 4.5A)
 0.51A 1mxdA-4uzuA:
39.5		 1mxdA-4uzuA:
30.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 4uzu ALPHA-AMYLASE
(Geobacillus
stearothermophil
us) 		5 / 11 ILE A  88
ALA A  91
VAL A  98
LEU A  65
ALA A  46
 None
 1.23A 1n4hA-4uzuA:
undetectable		 1n4hA-4uzuA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OWC_A_ACRA600_1
(4-ALPHA-GLUCANOTRANS
FERASE)		 4uzu ALPHA-AMYLASE
(Geobacillus
stearothermophil
us) 		5 / 11 TYR A  57
ASP A 232
HIS A 328
ASP A 329
TRP A  14
 None
NA  A1490 (-2.9A)
None
NA  A1490 ( 4.5A)
None
 0.94A 2owcA-4uzuA:
14.4		 2owcA-4uzuA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OWW_A_ACRA600_1
(4-ALPHA-GLUCANOTRANS
FERASE)		 4uzu ALPHA-AMYLASE
(Geobacillus
stearothermophil
us) 		5 / 11 TYR A  57
ASP A 232
HIS A 328
ASP A 329
TRP A  14
 None
NA  A1490 (-2.9A)
None
NA  A1490 ( 4.5A)
None
 0.97A 2owwA-4uzuA:
14.6		 2owwA-4uzuA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4uzu ALPHA-AMYLASE
(Geobacillus
stearothermophil
us) 		4 / 8 LEU A 202
PRO A  45
VAL A  59
GLY A  58
 None
 1.00A 2po5A-4uzuA:
undetectable		 2po5A-4uzuA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_D_SAMD603_0
(HYPOTHETICAL PROTEIN)		 4uzu ALPHA-AMYLASE
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A 382
GLY A 365
GLY A 369
PHE A  12
ASP A 366
 None
 1.19A 2yvlD-4uzuA:
undetectable		 2yvlD-4uzuA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_1
(GLUCOSYLTRANSFERASE-
SI)		 4uzu ALPHA-AMYLASE
(Geobacillus
stearothermophil
us) 		7 / 12 LEU A 197
ARG A 230
ASP A 232
ALA A 233
GLU A 262
HIS A 328
ASP A 329
 None
NA  A1490 ( 4.1A)
NA  A1490 (-2.9A)
NA  A1490 ( 4.2A)
NA  A1490 (-2.7A)
None
NA  A1490 ( 4.5A)
 0.59A 3aicA-4uzuA:
11.6		 3aicA-4uzuA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_1
(GLUCOSYLTRANSFERASE-
SI)		 4uzu ALPHA-AMYLASE
(Geobacillus
stearothermophil
us) 		7 / 12 LEU A 197
ARG A 230
ASP A 232
ALA A 233
GLU A 262
HIS A 328
ASP A 329
 None
NA  A1490 ( 4.1A)
NA  A1490 (-2.9A)
NA  A1490 ( 4.2A)
NA  A1490 (-2.7A)
None
NA  A1490 ( 4.5A)
 0.58A 3aicB-4uzuA:
7.2		 3aicB-4uzuA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_C_ACRC5044_1
(GLUCOSYLTRANSFERASE-
SI)		 4uzu ALPHA-AMYLASE
(Geobacillus
stearothermophil
us) 		7 / 12 ARG A 230
ASP A 232
ALA A 233
GLU A 262
HIS A 328
ASP A 329
TYR A  57
 NA  A1490 ( 4.1A)
NA  A1490 (-2.9A)
NA  A1490 ( 4.2A)
NA  A1490 (-2.7A)
None
NA  A1490 ( 4.5A)
None
 0.61A 3aicC-4uzuA:
11.7		 3aicC-4uzuA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_D_ACRD5044_1
(GLUCOSYLTRANSFERASE-
SI)		 4uzu ALPHA-AMYLASE
(Geobacillus
stearothermophil
us) 		7 / 12 LEU A 197
ARG A 230
ASP A 232
ALA A 233
GLU A 262
HIS A 328
ASP A 329
 None
NA  A1490 ( 4.1A)
NA  A1490 (-2.9A)
NA  A1490 ( 4.2A)
NA  A1490 (-2.7A)
None
NA  A1490 ( 4.5A)
 0.65A 3aicD-4uzuA:
11.7		 3aicD-4uzuA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_1
(GLUCOSYLTRANSFERASE-
SI)		 4uzu ALPHA-AMYLASE
(Geobacillus
stearothermophil
us) 		7 / 12 LEU A 197
ARG A 230
ASP A 232
ALA A 233
GLU A 262
HIS A 328
ASP A 329
 None
NA  A1490 ( 4.1A)
NA  A1490 (-2.9A)
NA  A1490 ( 4.2A)
NA  A1490 (-2.7A)
None
NA  A1490 ( 4.5A)
 0.63A 3aicE-4uzuA:
11.7		 3aicE-4uzuA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_1
(GLUCOSYLTRANSFERASE-
SI)		 4uzu ALPHA-AMYLASE
(Geobacillus
stearothermophil
us) 		7 / 12 LEU A 197
ARG A 230
ASP A 232
ALA A 233
GLU A 262
HIS A 328
ASP A 329
 None
NA  A1490 ( 4.1A)
NA  A1490 (-2.9A)
NA  A1490 ( 4.2A)
NA  A1490 (-2.7A)
None
NA  A1490 ( 4.5A)
 0.61A 3aicF-4uzuA:
11.6		 3aicF-4uzuA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_1
(GLUCOSYLTRANSFERASE-
SI)		 4uzu ALPHA-AMYLASE
(Geobacillus
stearothermophil
us) 		7 / 12 LEU A 197
ARG A 230
ASP A 232
ALA A 233
GLU A 262
HIS A 328
ASP A 329
 None
NA  A1490 ( 4.1A)
NA  A1490 (-2.9A)
NA  A1490 ( 4.2A)
NA  A1490 (-2.7A)
None
NA  A1490 ( 4.5A)
 0.57A 3aicG-4uzuA:
11.6		 3aicG-4uzuA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_1
(GLUCOSYLTRANSFERASE-
SI)		 4uzu ALPHA-AMYLASE
(Geobacillus
stearothermophil
us) 		7 / 12 LEU A 197
ARG A 230
ASP A 232
ALA A 233
GLU A 262
HIS A 328
ASP A 329
 None
NA  A1490 ( 4.1A)
NA  A1490 (-2.9A)
NA  A1490 ( 4.2A)
NA  A1490 (-2.7A)
None
NA  A1490 ( 4.5A)
 0.67A 3aicH-4uzuA:
11.6		 3aicH-4uzuA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4uzu ALPHA-AMYLASE
(Geobacillus
stearothermophil
us) 		5 / 10 ILE A 237
GLY A 217
TYR A  47
VAL A  59
LEU A 231
 None
 1.13A 3elzC-4uzuA:
2.2		 3elzC-4uzuA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB0_A_DIFA701_1
(LACTOTRANSFERRIN)		 4uzu ALPHA-AMYLASE
(Geobacillus
stearothermophil
us) 		4 / 4 PRO A  45
TYR A  57
GLY A  58
THR A  50
 None
 1.47A 3ib0A-4uzuA:
undetectable		 3ib0A-4uzuA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_1
(STRUCTURAL PROTEIN
VP3)		 4uzu ALPHA-AMYLASE
(Geobacillus
stearothermophil
us) 		3 / 3 GLU A 262
ASP A 101
ASP A 105
 NA  A1490 (-2.7A)
None
CA  A1484 (-3.2A)
 0.75A 3jb2A-4uzuA:
undetectable		 3jb2A-4uzuA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 4uzu ALPHA-AMYLASE
(Geobacillus
stearothermophil
us) 		3 / 3 HIS A 106
PHE A 241
PHE A 242
 None
 0.77A 3lk0D-4uzuA:
undetectable		 3lk0D-4uzuA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_B_9PLB501_1
(CYTOCHROME P450 2A6)		 4uzu ALPHA-AMYLASE
(Geobacillus
stearothermophil
us) 		5 / 10 PHE A 293
PHE A 344
PHE A 351
ALA A 350
THR A 354
 None
 1.49A 3t3qB-4uzuA:
undetectable		 3t3qB-4uzuA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_2
(NEURAMINIDASE)		 4uzu ALPHA-AMYLASE
(Geobacillus
stearothermophil
us) 		3 / 3 ARG A 355
ARG A 411
TRP A 409
 None
 1.08A 4b7nA-4uzuA:
undetectable		 4b7nA-4uzuA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_2
(NEURAMINIDASE)		 4uzu ALPHA-AMYLASE
(Geobacillus
stearothermophil
us) 		3 / 3 ARG A 355
ARG A 411
TRP A 409
 None
 1.17A 4cpzC-4uzuA:
undetectable		 4cpzC-4uzuA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_2
(NEURAMINIDASE)		 4uzu ALPHA-AMYLASE
(Geobacillus
stearothermophil
us) 		3 / 3 ARG A 355
ARG A 411
TRP A 409
 None
 1.15A 4cpzE-4uzuA:
undetectable		 4cpzE-4uzuA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_2
(NEURAMINIDASE)		 4uzu ALPHA-AMYLASE
(Geobacillus
stearothermophil
us) 		3 / 3 ARG A 355
ARG A 411
TRP A 409
 None
 1.08A 4cpzF-4uzuA:
undetectable		 4cpzF-4uzuA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_2
(NEURAMINIDASE)		 4uzu ALPHA-AMYLASE
(Geobacillus
stearothermophil
us) 		3 / 3 ARG A 355
ARG A 411
TRP A 409
 None
 1.12A 4cpzG-4uzuA:
undetectable		 4cpzG-4uzuA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_2
(NEURAMINIDASE)		 4uzu ALPHA-AMYLASE
(Geobacillus
stearothermophil
us) 		3 / 3 ARG A 355
ARG A 411
TRP A 409
 None
 1.09A 4cpzH-4uzuA:
undetectable		 4cpzH-4uzuA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_B_NCTB501_1
(CYTOCHROME P450 2A6)		 4uzu ALPHA-AMYLASE
(Geobacillus
stearothermophil
us) 		4 / 7 PHE A 104
ASN A 215
GLY A 217
PHE A 241
 None
 0.97A 4ejjB-4uzuA:
undetectable		 4ejjB-4uzuA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_1
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 4uzu ALPHA-AMYLASE
(Geobacillus
stearothermophil
us) 		5 / 12 ARG A 230
ASP A 232
GLU A 262
HIS A 328
ASP A 329
 NA  A1490 ( 4.1A)
NA  A1490 (-2.9A)
NA  A1490 (-2.7A)
None
NA  A1490 ( 4.5A)
 0.49A 5csyB-4uzuA:
5.0		 5csyB-4uzuA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 4uzu ALPHA-AMYLASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 300
SER A 299
PHE A 303
VAL A 470
PRO A 346
 None
 1.07A 5ergB-4uzuA:
undetectable		 5ergB-4uzuA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4uzu ALPHA-AMYLASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 192
ASN A 193
ALA A 182
SER A 131
ILE A 130
 None
None
CL  A1487 (-3.8A)
None
None
 1.23A 5igyA-4uzuA:
2.2		 5igyA-4uzuA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4uzu ALPHA-AMYLASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 192
ASN A 193
ALA A 182
SER A 131
ILE A 130
 None
None
CL  A1487 (-3.8A)
None
None
 1.21A 5ih0A-4uzuA:
undetectable		 5ih0A-4uzuA:
19.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AG0_A_ACRA605_0
(ALPHA-AMYLASE)		 4uzu ALPHA-AMYLASE
(Geobacillus
stearothermophil
us) 		7 / 8 TYR A 159
GLY A 180
LYS A 181
ASP A 203
ASP A 205
HIS A 206
PRO A 207
 None
None
None
CA  A1483 (-3.0A)
None
None
None
 1.00A 6ag0A-4uzuA:
67.2		 6ag0A-4uzuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AG0_A_ACRA607_0
(ALPHA-AMYLASE)		 4uzu ALPHA-AMYLASE
(Geobacillus
stearothermophil
us) 		4 / 4 ARG A 454
SER A 455
ASP A 456
ASN A 471
 None
 0.60A 6ag0A-4uzuA:
67.2		 6ag0A-4uzuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)		 4uzu ALPHA-AMYLASE
(Geobacillus
stearothermophil
us) 		5 / 6 GLY A   6
THR A  39
GLN A  97
TYR A  99
TYR A 359
 None
 0.21A 6ag0A-4uzuA:
67.2		 6ag0A-4uzuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AG0_A_ACRA609_0
(ALPHA-AMYLASE)		 4uzu ALPHA-AMYLASE
(Geobacillus
stearothermophil
us) 		7 / 7 LYS A  71
GLY A 109
TRP A 139
ASP A 165
TRP A 166
MET A 198
TYR A 199
 None
GLY  A1489 (-3.6A)
GLY  A1489 ( 4.8A)
None
None
None
GLY  A1489 (-4.8A)
 0.54A 6ag0A-4uzuA:
67.2		 6ag0A-4uzuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AG0_A_ACRA610_0
(ALPHA-AMYLASE)		 4uzu ALPHA-AMYLASE
(Geobacillus
stearothermophil
us) 		12 / 12 TRP A  14
TYR A  57
HIS A 106
GLU A 190
TYR A 194
LEU A 197
MET A 198
ASP A 232
LYS A 235
HIS A 236
HIS A 328
ASP A 329
 None
None
None
None
None
None
None
NA  A1490 (-2.9A)
None
None
None
NA  A1490 ( 4.5A)
 0.31A 6ag0A-4uzuA:
67.2		 6ag0A-4uzuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AG0_C_ACRC605_0
(ALPHA-AMYLASE)		 4uzu ALPHA-AMYLASE
(Geobacillus
stearothermophil
us) 		6 / 8 GLY A 180
LYS A 181
ASP A 203
ASP A 205
HIS A 206
PRO A 207
 None
None
CA  A1483 (-3.0A)
None
None
None
 0.96A 6ag0C-4uzuA:
67.4		 6ag0C-4uzuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AG0_C_ACRC605_0
(ALPHA-AMYLASE)		 4uzu ALPHA-AMYLASE
(Geobacillus
stearothermophil
us) 		6 / 8 TYR A 159
LYS A 181
ASP A 203
ASP A 205
HIS A 206
PRO A 207
 None
None
CA  A1483 (-3.0A)
None
None
None
 0.89A 6ag0C-4uzuA:
67.4		 6ag0C-4uzuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)		 4uzu ALPHA-AMYLASE
(Geobacillus
stearothermophil
us) 		5 / 6 GLY A   6
THR A  39
GLN A  97
TYR A  99
TYR A 359
 None
 0.19A 6ag0C-4uzuA:
67.4		 6ag0C-4uzuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)		 4uzu ALPHA-AMYLASE
(Geobacillus
stearothermophil
us) 		6 / 6 GLY A 300
ASP A 341
TRP A 343
GLY A 429
PRO A 430
GLY A 473
 None
 0.28A 6ag0C-4uzuA:
67.4		 6ag0C-4uzuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AG0_C_ACRC608_0
(ALPHA-AMYLASE)		 4uzu ALPHA-AMYLASE
(Geobacillus
stearothermophil
us) 		12 / 12 TRP A  14
GLU A 190
TYR A 194
LEU A 197
MET A 198
ASP A 232
LYS A 235
HIS A 236
TYR A 266
HIS A 328
ASP A 329
GLN A 334
 None
None
None
None
None
NA  A1490 (-2.9A)
None
None
None
None
NA  A1490 ( 4.5A)
None
 0.30A 6ag0C-4uzuA:
67.4		 6ag0C-4uzuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AG0_C_ACRC609_0
(ALPHA-AMYLASE)		 4uzu ALPHA-AMYLASE
(Geobacillus
stearothermophil
us) 		7 / 7 LYS A  71
GLY A 109
TRP A 139
ASP A 165
TRP A 166
MET A 198
TYR A 199
 None
GLY  A1489 (-3.6A)
GLY  A1489 ( 4.8A)
None
None
None
GLY  A1489 (-4.8A)
 0.46A 6ag0C-4uzuA:
67.4		 6ag0C-4uzuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_2
(RIFAMPIN
MONOOXYGENASE)		 4uzu ALPHA-AMYLASE
(Geobacillus
stearothermophil
us) 		4 / 4 GLN A 397
VAL A 438
ARG A 306
ARG A 355
 None
 1.49A 6brdA-4uzuA:
1.6		 6brdA-4uzuA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 4uzu ALPHA-AMYLASE
(Geobacillus
stearothermophil
us) 		4 / 8 ARG A 230
VAL A 209
ARG A 147
GLN A  70
 NA  A1490 ( 4.1A)
None
None
None
 1.16A 6fbvD-4uzuA:
undetectable		 6fbvD-4uzuA:
17.66