SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uzv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 4uzv HEMOGLOBIN
(Thermobifida
fusca) 		4 / 7 PHE A  53
PHE A  54
PHE A  67
HIS A 106
 None
None
HEM  A1157 ( 3.7A)
HEM  A1157 (-3.3A)
 0.78A 1lh6A-4uzvA:
2.9		 1lh6A-4uzvA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 4uzv HEMOGLOBIN
(Thermobifida
fusca) 		6 / 11 LEU A 130
LEU A 140
LEU A  83
LEU A  49
ARG A  48
ARG A  80
 None
None
HEM  A1157 (-4.9A)
None
None
None
 1.27A 2ceoA-4uzvA:
undetectable		 2ceoA-4uzvA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_B_T44B1395_1
(THYROXINE-BINDING
GLOBULIN)		 4uzv HEMOGLOBIN
(Thermobifida
fusca) 		5 / 10 LEU A 130
LEU A 140
LEU A  83
ARG A  48
ARG A  80
 None
None
HEM  A1157 (-4.9A)
None
None
 1.21A 2ceoB-4uzvA:
undetectable		 2ceoB-4uzvA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 4uzv HEMOGLOBIN
(Thermobifida
fusca) 		6 / 10 LEU A 130
LEU A 140
LEU A  83
LEU A  49
ARG A  48
ARG A  80
 None
None
HEM  A1157 (-4.9A)
None
None
None
 1.12A 2riwA-4uzvA:
undetectable
2riwB-4uzvA:
undetectable		 2riwA-4uzvA:
17.63
2riwB-4uzvA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_2
(ADENOSYLHOMOCYSTEINA
SE)		 4uzv HEMOGLOBIN
(Thermobifida
fusca) 		4 / 5 GLN A  85
THR A  92
GLU A  43
THR A  47
 None
 1.44A 3glqA-4uzvA:
undetectable		 3glqA-4uzvA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4uzv HEMOGLOBIN
(Thermobifida
fusca) 		3 / 3 LEU A 132
PRO A 133
LEU A 136
 None
 0.47A 3w1wB-4uzvA:
undetectable		 3w1wB-4uzvA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4uzv HEMOGLOBIN
(Thermobifida
fusca) 		3 / 3 TYR A 143
ALA A 150
TYR A 146
 None
 0.79A 5uunB-4uzvA:
undetectable		 5uunB-4uzvA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4uzv HEMOGLOBIN
(Thermobifida
fusca) 		3 / 3 ARG A  48
PHE A  53
LEU A 130
 None
 0.88A 5x1bC-4uzvA:
undetectable		 5x1bC-4uzvA:
17.65