SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uzz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4uzz INTRAFLAGELLAR
TRANSPORT COMPLEX B
PROTEIN 46
CARBOXY-TERMINAL
PROTEIN
INTRAFLAGELLAR
TRANSPORTER-LIKE
PROTEIN
(Tetrahymena
thermophila;
Tetrahymena
thermophila) 		4 / 7 LEU A 307
ILE A 309
ALA A 303
ILE B 565
 None
 0.88A 1oniB-4uzzA:
undetectable
1oniC-4uzzA:
undetectable		 1oniB-4uzzA:
20.14
1oniC-4uzzA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4uzz INTRAFLAGELLAR
TRANSPORT COMPLEX B
PROTEIN 46
CARBOXY-TERMINAL
PROTEIN
INTRAFLAGELLAR
TRANSPORTER-LIKE
PROTEIN
(Tetrahymena
thermophila;
Tetrahymena
thermophila) 		4 / 8 HIS A 312
PRO A 310
SER A 318
THR B 553
 None
 1.21A 1p7lC-4uzzA:
undetectable		 1p7lC-4uzzA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4uzz INTRAFLAGELLAR
TRANSPORT COMPLEX B
PROTEIN 46
CARBOXY-TERMINAL
PROTEIN
INTRAFLAGELLAR
TRANSPORTER-LIKE
PROTEIN
(Tetrahymena
thermophila;
Tetrahymena
thermophila) 		4 / 8 HIS A 312
PRO A 310
SER A 318
THR B 553
 None
 1.21A 1p7lD-4uzzA:
undetectable		 1p7lD-4uzzA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4uzz INTRAFLAGELLAR
TRANSPORT COMPLEX B
PROTEIN 46
CARBOXY-TERMINAL
PROTEIN
INTRAFLAGELLAR
TRANSPORTER-LIKE
PROTEIN
(Tetrahymena
thermophila;
Tetrahymena
thermophila) 		4 / 8 HIS A 312
PRO A 310
SER A 318
THR B 553
 None
 1.21A 1rg9A-4uzzA:
undetectable		 1rg9A-4uzzA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4uzz INTRAFLAGELLAR
TRANSPORT COMPLEX B
PROTEIN 46
CARBOXY-TERMINAL
PROTEIN
INTRAFLAGELLAR
TRANSPORTER-LIKE
PROTEIN
(Tetrahymena
thermophila;
Tetrahymena
thermophila) 		4 / 8 HIS A 312
PRO A 310
SER A 318
THR B 553
 None
 1.21A 1rg9B-4uzzA:
undetectable		 1rg9B-4uzzA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4uzz INTRAFLAGELLAR
TRANSPORT COMPLEX B
PROTEIN 46
CARBOXY-TERMINAL
PROTEIN
INTRAFLAGELLAR
TRANSPORTER-LIKE
PROTEIN
(Tetrahymena
thermophila;
Tetrahymena
thermophila) 		4 / 8 HIS A 312
PRO A 310
SER A 318
THR B 553
 None
 1.21A 1rg9C-4uzzA:
undetectable		 1rg9C-4uzzA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4uzz INTRAFLAGELLAR
TRANSPORT COMPLEX B
PROTEIN 46
CARBOXY-TERMINAL
PROTEIN
INTRAFLAGELLAR
TRANSPORTER-LIKE
PROTEIN
(Tetrahymena
thermophila;
Tetrahymena
thermophila) 		4 / 8 HIS A 312
PRO A 310
SER A 318
THR B 553
 None
 1.21A 1rg9D-4uzzA:
undetectable		 1rg9D-4uzzA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4uzz INTRAFLAGELLAR
TRANSPORT COMPLEX B
PROTEIN 46
CARBOXY-TERMINAL
PROTEIN
INTRAFLAGELLAR
TRANSPORTER-LIKE
PROTEIN
(Tetrahymena
thermophila) 		5 / 12 LEU A 296
CYH A 300
LEU A 302
ALA A 303
LEU B 592
 None
 0.88A 1s9pB-4uzzA:
undetectable		 1s9pB-4uzzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_C_DESC500_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4uzz INTRAFLAGELLAR
TRANSPORT COMPLEX B
PROTEIN 46
CARBOXY-TERMINAL
PROTEIN
INTRAFLAGELLAR
TRANSPORTER-LIKE
PROTEIN
(Tetrahymena
thermophila) 		5 / 12 LEU A 296
CYH A 300
LEU A 302
ALA A 303
LEU B 592
 None
 0.89A 1s9pC-4uzzA:
undetectable		 1s9pC-4uzzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4uzz INTRAFLAGELLAR
TRANSPORTER-LIKE
PROTEIN
(Tetrahymena
thermophila) 		3 / 3 SER B 544
GLU B 567
ASP B 560
 None
 0.71A 2zulA-4uzzB:
undetectable		 2zulA-4uzzB:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4uzz INTRAFLAGELLAR
TRANSPORTER-LIKE
PROTEIN
(Tetrahymena
thermophila) 		3 / 3 SER B 544
GLU B 567
ASP B 560
 None
 0.73A 3dmhA-4uzzB:
undetectable		 3dmhA-4uzzB:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 4uzz INTRAFLAGELLAR
TRANSPORT COMPLEX B
PROTEIN 46
CARBOXY-TERMINAL
PROTEIN
(Tetrahymena
thermophila) 		4 / 7 ALA A 303
LEU A 327
LEU A 330
ILE A 306
 None
 0.75A 4ubsA-4uzzA:
undetectable		 4ubsA-4uzzA:
13.51