SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4v06'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4v06 TRYPTOPHAN
5-HYDROXYLASE 2
(Homo
sapiens) 		5 / 7 VAL A 278
LEU A 282
PHE A 287
LEU A 288
ALA A 355
 None
None
IMD  A 600 ( 4.4A)
None
None
 0.25A 1j8uA-4v06A:
48.0		 1j8uA-4v06A:
61.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4v06 TRYPTOPHAN
5-HYDROXYLASE 2
(Homo
sapiens) 		6 / 12 VAL A 278
LEU A 282
PHE A 287
LEU A 288
THR A 299
TYR A 358
 None
None
IMD  A 600 ( 4.4A)
None
None
None
 0.96A 1kw0A-4v06A:
41.7		 1kw0A-4v06A:
61.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4v06 TRYPTOPHAN
5-HYDROXYLASE 2
(Homo
sapiens) 		7 / 12 VAL A 278
PHE A 287
LEU A 288
THR A 299
GLU A 319
HIS A 323
TYR A 358
 None
IMD  A 600 ( 4.4A)
None
None
IMD  A 600 (-3.3A)
FE  A1491 ( 3.3A)
None
 0.97A 1kw0A-4v06A:
41.7		 1kw0A-4v06A:
61.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4v06 TRYPTOPHAN
5-HYDROXYLASE 2
(Homo
sapiens) 		7 / 12 VAL A 278
PHE A 287
THR A 299
GLU A 319
HIS A 323
TYR A 358
GLU A 363
 None
IMD  A 600 ( 4.4A)
None
IMD  A 600 (-3.3A)
FE  A1491 ( 3.3A)
None
FE  A1491 ( 2.0A)
 0.98A 1kw0A-4v06A:
41.7		 1kw0A-4v06A:
61.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4v06 TRYPTOPHAN
5-HYDROXYLASE 2
(Homo
sapiens) 		7 / 12 VAL A 278
LEU A 282
PHE A 287
GLU A 319
HIS A 323
TYR A 358
GLU A 363
 None
None
IMD  A 600 ( 4.4A)
IMD  A 600 (-3.3A)
FE  A1491 ( 3.3A)
None
FE  A1491 ( 2.0A)
 1.09A 1mmkA-4v06A:
41.8		 1mmkA-4v06A:
61.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4v06 TRYPTOPHAN
5-HYDROXYLASE 2
(Homo
sapiens) 		7 / 12 VAL A 278
LEU A 282
PHE A 287
LEU A 288
GLU A 319
HIS A 323
TYR A 358
 None
None
IMD  A 600 ( 4.4A)
None
IMD  A 600 (-3.3A)
FE  A1491 ( 3.3A)
None
 0.99A 1mmkA-4v06A:
41.8		 1mmkA-4v06A:
61.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4v06 TRYPTOPHAN
5-HYDROXYLASE 2
(Homo
sapiens) 		7 / 11 VAL A 278
LEU A 282
PHE A 287
LEU A 288
THR A 299
HIS A 323
TYR A 358
 None
None
IMD  A 600 ( 4.4A)
None
None
FE  A1491 ( 3.3A)
None
 0.93A 1mmtA-4v06A:
41.7		 1mmtA-4v06A:
61.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4v06 TRYPTOPHAN
5-HYDROXYLASE 2
(Homo
sapiens) 		7 / 11 VAL A 278
LEU A 282
PHE A 287
THR A 299
HIS A 323
TYR A 358
GLU A 363
 None
None
IMD  A 600 ( 4.4A)
None
FE  A1491 ( 3.3A)
None
FE  A1491 ( 2.0A)
 1.03A 1mmtA-4v06A:
41.7		 1mmtA-4v06A:
61.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4v06 TRYPTOPHAN
5-HYDROXYLASE 2
(Homo
sapiens) 		7 / 11 VAL A 278
PHE A 287
LEU A 288
THR A 299
GLU A 319
HIS A 323
TYR A 358
 None
IMD  A 600 ( 4.4A)
None
None
IMD  A 600 (-3.3A)
FE  A1491 ( 3.3A)
None
 0.87A 1mmtA-4v06A:
41.7		 1mmtA-4v06A:
61.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4v06 TRYPTOPHAN
5-HYDROXYLASE 2
(Homo
sapiens) 		7 / 11 VAL A 278
PHE A 287
THR A 299
GLU A 319
HIS A 323
TYR A 358
GLU A 363
 None
IMD  A 600 ( 4.4A)
None
IMD  A 600 (-3.3A)
FE  A1491 ( 3.3A)
None
FE  A1491 ( 2.0A)
 0.91A 1mmtA-4v06A:
41.7		 1mmtA-4v06A:
61.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOW_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 4v06 TRYPTOPHAN
5-HYDROXYLASE 2
(Homo
sapiens) 		4 / 7 PHE A 425
GLU A 238
GLN A 369
GLU A 427
 None
 1.17A 2aowA-4v06A:
undetectable		 2aowA-4v06A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OBV_A_SAMA501_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1)		 4v06 TRYPTOPHAN
5-HYDROXYLASE 2
(Homo
sapiens) 		4 / 8 HIS A 318
PRO A 314
SER A 336
PHE A 296
 FE  A1491 ( 3.5A)
IMD  A 600 ( 4.7A)
None
IMD  A 600 (-4.7A)
 1.22A 2obvA-4v06A:
undetectable		 2obvA-4v06A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_2
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 4v06 TRYPTOPHAN
5-HYDROXYLASE 2
(Homo
sapiens) 		3 / 3 ARG A 209
GLU A 261
GLN A 259
 None
 1.02A 2p16A-4v06A:
undetectable		 2p16A-4v06A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4v06 TRYPTOPHAN
5-HYDROXYLASE 2
(Homo
sapiens) 		5 / 12 HIS A 318
GLU A 319
HIS A 323
GLU A 363
TYR A 281
 FE  A1491 ( 3.5A)
IMD  A 600 (-3.3A)
FE  A1491 ( 3.3A)
FE  A1491 ( 2.0A)
None
 1.41A 2x91A-4v06A:
undetectable		 2x91A-4v06A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_C_CHDC1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4v06 TRYPTOPHAN
5-HYDROXYLASE 2
(Homo
sapiens) 		4 / 5 PHE A 335
PHE A 332
LEU A 327
PHE A 296
 None
None
None
IMD  A 600 (-4.7A)
 1.32A 2y69C-4v06A:
undetectable
2y69J-4v06A:
undetectable		 2y69C-4v06A:
21.41
2y69J-4v06A:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_P_CHDP1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4v06 TRYPTOPHAN
5-HYDROXYLASE 2
(Homo
sapiens) 		4 / 5 PHE A 335
PHE A 332
LEU A 327
PHE A 296
 None
None
None
IMD  A 600 (-4.7A)
 1.30A 2y69P-4v06A:
undetectable
2y69W-4v06A:
undetectable		 2y69P-4v06A:
21.41
2y69W-4v06A:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4v06 TRYPTOPHAN
5-HYDROXYLASE 2
(Homo
sapiens) 		4 / 5 PHE A 335
PHE A 332
LEU A 327
PHE A 296
 None
None
None
IMD  A 600 (-4.7A)
 1.32A 3abmC-4v06A:
undetectable
3abmJ-4v06A:
undetectable		 3abmC-4v06A:
21.41
3abmJ-4v06A:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4v06 TRYPTOPHAN
5-HYDROXYLASE 2
(Homo
sapiens) 		4 / 5 PHE A 335
PHE A 332
LEU A 327
PHE A 296
 None
None
None
IMD  A 600 (-4.7A)
 1.28A 3abmP-4v06A:
undetectable
3abmW-4v06A:
undetectable		 3abmP-4v06A:
21.41
3abmW-4v06A:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4v06 TRYPTOPHAN
5-HYDROXYLASE 2
(Homo
sapiens) 		4 / 5 PHE A 335
PHE A 332
LEU A 327
PHE A 296
 None
None
None
IMD  A 600 (-4.7A)
 1.35A 3ag3C-4v06A:
undetectable
3ag3J-4v06A:
undetectable		 3ag3C-4v06A:
21.41
3ag3J-4v06A:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_A_ADNA438_1
(ADENOSYLHOMOCYSTEINA
SE)		 4v06 TRYPTOPHAN
5-HYDROXYLASE 2
(Homo
sapiens) 		5 / 12 GLU A 238
ASN A 242
LEU A 381
GLY A 322
PHE A 425
 None
 1.25A 3g1uA-4v06A:
undetectable		 3g1uA-4v06A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_2
(FIV PROTEASE)		 4v06 TRYPTOPHAN
5-HYDROXYLASE 2
(Homo
sapiens) 		5 / 10 LEU A 341
ALA A 289
ILE A 158
VAL A 445
LEU A 344
 None
 1.14A 3ogpB-4v06A:
undetectable		 3ogpB-4v06A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_2
(FIV PROTEASE)		 4v06 TRYPTOPHAN
5-HYDROXYLASE 2
(Homo
sapiens) 		5 / 12 LEU A 341
GLY A 290
ALA A 289
ILE A 158
LEU A 344
 None
 1.04A 3ogqB-4v06A:
undetectable		 3ogqB-4v06A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4v06 TRYPTOPHAN
5-HYDROXYLASE 2
(Homo
sapiens) 		5 / 12 LEU A 148
GLY A 345
ALA A 292
PRO A 155
LEU A 161
 None
 1.01A 3tm4A-4v06A:
undetectable		 3tm4A-4v06A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4v06 TRYPTOPHAN
5-HYDROXYLASE 2
(Homo
sapiens) 		5 / 12 LEU A 148
GLY A 345
ALA A 292
PRO A 155
LEU A 161
 None
 0.99A 3tm4B-4v06A:
undetectable		 3tm4B-4v06A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 4v06 TRYPTOPHAN
5-HYDROXYLASE 2
(Homo
sapiens) 		4 / 7 TYR A 310
SER A 306
HIS A 179
HIS A 304
 None
 1.21A 4arcA-4v06A:
undetectable		 4arcA-4v06A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4v06 TRYPTOPHAN
5-HYDROXYLASE 2
(Homo
sapiens) 		5 / 12 GLU A 386
ILE A 362
LEU A 326
GLY A 379
SER A 383
 None
 1.42A 4djfB-4v06A:
undetectable		 4djfB-4v06A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4v06 TRYPTOPHAN
5-HYDROXYLASE 2
(Homo
sapiens) 		3 / 3 ARG A 191
HIS A 179
TYR A 301
 None
 0.97A 4fu8A-4v06A:
undetectable		 4fu8A-4v06A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4v06 TRYPTOPHAN
5-HYDROXYLASE 2
(Homo
sapiens) 		3 / 3 ARG A 191
HIS A 179
TYR A 301
 None
 0.92A 4fu9A-4v06A:
undetectable		 4fu9A-4v06A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4v06 TRYPTOPHAN
5-HYDROXYLASE 2
(Homo
sapiens) 		4 / 8 HIS A 318
PRO A 314
SER A 336
PHE A 296
 FE  A1491 ( 3.5A)
IMD  A 600 ( 4.7A)
None
IMD  A 600 (-4.7A)
 1.16A 4kttC-4v06A:
undetectable		 4kttC-4v06A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTV_C_ADNC403_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4v06 TRYPTOPHAN
5-HYDROXYLASE 2
(Homo
sapiens) 		5 / 11 HIS A 318
PRO A 314
SER A 336
PHE A 296
ILE A 362
 FE  A1491 ( 3.5A)
IMD  A 600 ( 4.7A)
None
IMD  A 600 (-4.7A)
None
 1.22A 4ktvC-4v06A:
undetectable
4ktvD-4v06A:
undetectable		 4ktvC-4v06A:
20.49
4ktvD-4v06A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4v06 TRYPTOPHAN
5-HYDROXYLASE 2
(Homo
sapiens) 		4 / 8 HIS A 318
PRO A 314
SER A 336
PHE A 296
 FE  A1491 ( 3.5A)
IMD  A 600 ( 4.7A)
None
IMD  A 600 (-4.7A)
 1.20A 4ndnA-4v06A:
undetectable		 4ndnA-4v06A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4v06 TRYPTOPHAN
5-HYDROXYLASE 2
(Homo
sapiens) 		4 / 7 HIS A 318
PRO A 314
SER A 336
PHE A 296
 FE  A1491 ( 3.5A)
IMD  A 600 ( 4.7A)
None
IMD  A 600 (-4.7A)
 1.20A 4ndnC-4v06A:
undetectable		 4ndnC-4v06A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4v06 TRYPTOPHAN
5-HYDROXYLASE 2
(Homo
sapiens) 		4 / 7 HIS A 318
PRO A 314
SER A 336
PHE A 296
 FE  A1491 ( 3.5A)
IMD  A 600 ( 4.7A)
None
IMD  A 600 (-4.7A)
 1.24A 4odjA-4v06A:
undetectable		 4odjA-4v06A:
20.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 4v06 TRYPTOPHAN
5-HYDROXYLASE 2
(Homo
sapiens) 		5 / 6 PHE A 287
HIS A 318
HIS A 323
TYR A 358
GLU A 363
 IMD  A 600 ( 4.4A)
FE  A1491 ( 3.5A)
FE  A1491 ( 3.3A)
None
FE  A1491 ( 2.0A)
 0.48A 4pahA-4v06A:
47.9		 4pahA-4v06A:
64.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 4v06 TRYPTOPHAN
5-HYDROXYLASE 2
(Homo
sapiens) 		5 / 12 ALA A 355
HIS A 318
GLU A 319
HIS A 323
GLU A 363
 None
FE  A1491 ( 3.5A)
IMD  A 600 (-3.3A)
FE  A1491 ( 3.3A)
FE  A1491 ( 2.0A)
 0.91A 4r7lA-4v06A:
undetectable		 4r7lA-4v06A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 4v06 TRYPTOPHAN
5-HYDROXYLASE 2
(Homo
sapiens) 		3 / 3 GLU A 319
TYR A 358
GLU A 363
 IMD  A 600 (-3.3A)
None
FE  A1491 ( 2.0A)
 0.83A 4ryaA-4v06A:
undetectable		 4ryaA-4v06A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4v06 TRYPTOPHAN
5-HYDROXYLASE 2
(Homo
sapiens) 		4 / 7 HIS A 318
PRO A 314
SER A 336
PHE A 296
 FE  A1491 ( 3.5A)
IMD  A 600 ( 4.7A)
None
IMD  A 600 (-4.7A)
 1.24A 5a1iA-4v06A:
undetectable		 5a1iA-4v06A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_C_ACTC403_0
(D-ALANINE--D-ALANINE
LIGASE)		 4v06 TRYPTOPHAN
5-HYDROXYLASE 2
(Homo
sapiens) 		4 / 4 TYR A 231
GLY A 385
SER A 383
LEU A 387
 None
 1.38A 5bphC-4v06A:
undetectable		 5bphC-4v06A:
23.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5PAH_A_LDPA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 4v06 TRYPTOPHAN
5-HYDROXYLASE 2
(Homo
sapiens) 		4 / 4 HIS A 318
HIS A 323
TYR A 358
GLU A 363
 FE  A1491 ( 3.5A)
FE  A1491 ( 3.3A)
None
FE  A1491 ( 2.0A)
 0.53A 5pahA-4v06A:
47.7		 5pahA-4v06A:
64.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4v06 TRYPTOPHAN
5-HYDROXYLASE 2
(Homo
sapiens) 		4 / 5 PHE A 335
PHE A 332
LEU A 327
PHE A 296
 None
None
None
IMD  A 600 (-4.7A)
 1.34A 5wauC-4v06A:
undetectable
5wauJ-4v06A:
undetectable		 5wauC-4v06A:
21.41
5wauJ-4v06A:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4v06 TRYPTOPHAN
5-HYDROXYLASE 2
(Homo
sapiens) 		4 / 5 PHE A 335
PHE A 332
LEU A 327
PHE A 296
 None
None
None
IMD  A 600 (-4.7A)
 1.32A 5wauc-4v06A:
undetectable
5wauj-4v06A:
undetectable		 5wauc-4v06A:
21.41
5wauj-4v06A:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4v06 TRYPTOPHAN
5-HYDROXYLASE 2
(Homo
sapiens) 		4 / 5 PHE A 335
PHE A 332
LEU A 327
PHE A 296
 None
None
None
IMD  A 600 (-4.7A)
 1.28A 5xdqC-4v06A:
undetectable
5xdqJ-4v06A:
undetectable		 5xdqC-4v06A:
21.41
5xdqJ-4v06A:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4v06 TRYPTOPHAN
5-HYDROXYLASE 2
(Homo
sapiens) 		4 / 5 PHE A 335
PHE A 332
LEU A 327
PHE A 296
 None
None
None
IMD  A 600 (-4.7A)
 1.30A 5xdqP-4v06A:
undetectable
5xdqW-4v06A:
undetectable		 5xdqP-4v06A:
21.41
5xdqW-4v06A:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBP_B_ADNB404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4v06 TRYPTOPHAN
5-HYDROXYLASE 2
(Homo
sapiens) 		5 / 12 ILE A 362
HIS A 318
PRO A 314
SER A 336
PHE A 296
 None
FE  A1491 ( 3.5A)
IMD  A 600 ( 4.7A)
None
IMD  A 600 (-4.7A)
 1.21A 6fbpA-4v06A:
undetectable
6fbpB-4v06A:
undetectable		 6fbpA-4v06A:
13.88
6fbpB-4v06A:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCB_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4v06 TRYPTOPHAN
5-HYDROXYLASE 2
(Homo
sapiens) 		4 / 8 HIS A 318
PRO A 314
SER A 336
PHE A 296
 FE  A1491 ( 3.5A)
IMD  A 600 ( 4.7A)
None
IMD  A 600 (-4.7A)
 1.13A 6fcbA-4v06A:
undetectable		 6fcbA-4v06A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4v06 TRYPTOPHAN
5-HYDROXYLASE 2
(Homo
sapiens) 		4 / 7 HIS A 318
PRO A 314
SER A 336
PHE A 296
 FE  A1491 ( 3.5A)
IMD  A 600 ( 4.7A)
None
IMD  A 600 (-4.7A)
 1.24A 6g6rA-4v06A:
undetectable		 6g6rA-4v06A:
20.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 4v06 TRYPTOPHAN
5-HYDROXYLASE 2
(Homo
sapiens) 		5 / 6 PRO A 314
HIS A 318
HIS A 323
TYR A 358
GLU A 363
 IMD  A 600 ( 4.7A)
FE  A1491 ( 3.5A)
FE  A1491 ( 3.3A)
None
FE  A1491 ( 2.0A)
 0.48A 6pahA-4v06A:
47.7		 6pahA-4v06A:
64.56