SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4v08'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 4v08 UL26
(Suid
alphaherpesvirus
1) 		5 / 12 LEU A  73
ILE A  49
ILE A  39
LEU A 105
LEU A  97
 None
 1.17A 1xdkB-4v08A:
undetectable		 1xdkB-4v08A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4v08 UL26
(Suid
alphaherpesvirus
1) 		5 / 12 THR A 140
ILE A 141
GLY A 139
GLY A 135
ILE A 134
 None
None
None
DFP  A 300 (-3.6A)
None
 1.34A 2y7kC-4v08A:
undetectable		 2y7kC-4v08A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_0
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 4v08 UL26
(Suid
alphaherpesvirus
1) 		5 / 12 GLY A  35
ALA A  34
PHE A 126
ALA A  30
VAL A  27
 None
 1.18A 4ryaA-4v08A:
undetectable		 4ryaA-4v08A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 4v08 UL26
(Suid
alphaherpesvirus
1) 		5 / 12 ILE A  39
LEU A 131
VAL A  52
GLY A  66
TYR A 144
 None
 1.01A 5nnaB-4v08A:
undetectable		 5nnaB-4v08A:
25.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 4v08 UL26
(Suid
alphaherpesvirus
1) 		5 / 12 ILE A  39
LEU A 131
VAL A  52
GLY A  66
TYR A 144
 None
 0.96A 5nnaC-4v08A:
undetectable		 5nnaC-4v08A:
25.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4v08 UL26
(Suid
alphaherpesvirus
1) 		5 / 12 SER A   7
VAL A 143
ALA A 215
PRO A 148
GLY A   8
 None
 1.38A 5tzoA-4v08A:
undetectable		 5tzoA-4v08A:
20.61