SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4v0h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4v0h METALLO-BETA-LACTAMA
SE DOMAIN-CONTAINING
PROTEIN 1 1
(Homo
sapiens) 		5 / 12 LEU A 209
HIS A 172
ASP A 121
GLY A 194
HIS A 122
 None
FE  A1242 (-3.4A)
FE  A1243 (-2.9A)
None
FE  A1243 (-3.5A)
 1.38A 1d4fC-4v0hA:
undetectable		 1d4fC-4v0hA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_A_DVAA6_0
(GRAMICIDIN A)		 4v0h METALLO-BETA-LACTAMA
SE DOMAIN-CONTAINING
PROTEIN 1 1
(Homo
sapiens) 		3 / 3 ALA A 183
VAL A 191
TRP A 167
 None
 0.94A 1nrmA-4v0hA:
undetectable		 1nrmA-4v0hA:
6.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_B_DVAB6_0
(GRAMICIDIN A)		 4v0h METALLO-BETA-LACTAMA
SE DOMAIN-CONTAINING
PROTEIN 1 1
(Homo
sapiens) 		3 / 3 ALA A 183
VAL A 191
TRP A 167
 None
 0.93A 1nrmB-4v0hA:
undetectable		 1nrmB-4v0hA:
6.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)		 4v0h METALLO-BETA-LACTAMA
SE DOMAIN-CONTAINING
PROTEIN 1 1
(Homo
sapiens) 		3 / 3 ARG A 239
VAL A 182
THR A 185
 None
 0.77A 2nmzA-4v0hA:
undetectable		 2nmzA-4v0hA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 4v0h METALLO-BETA-LACTAMA
SE DOMAIN-CONTAINING
PROTEIN 1 1
(Homo
sapiens) 		5 / 11 ASP A 121
HIS A 122
HIS A 172
ASP A 195
HIS A 234
 FE  A1243 (-2.9A)
FE  A1243 (-3.5A)
FE  A1242 (-3.4A)
FE  A1243 ( 2.4A)
FE  A1243 (-3.2A)
 0.60A 2q0jB-4v0hA:
13.2		 2q0jB-4v0hA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBO_A_CAMA442_0
(CYTOCHROME P450-CAM)		 4v0h METALLO-BETA-LACTAMA
SE DOMAIN-CONTAINING
PROTEIN 1 1
(Homo
sapiens) 		5 / 10 THR A  48
VAL A 231
VAL A 230
VAL A  17
VAL A  24
 None
 1.39A 2qboA-4v0hA:
undetectable		 2qboA-4v0hA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 4v0h METALLO-BETA-LACTAMA
SE DOMAIN-CONTAINING
PROTEIN 1 1
(Homo
sapiens) 		3 / 3 ARG A 239
VAL A 182
THR A 185
 None
 0.74A 3k4vD-4v0hA:
undetectable		 3k4vD-4v0hA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_N_CLMN221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4v0h METALLO-BETA-LACTAMA
SE DOMAIN-CONTAINING
PROTEIN 1 1
(Homo
sapiens) 		5 / 11 THR A 169
SER A 179
LEU A 224
VAL A 240
PHE A 238
 None
 1.32A 3u9fN-4v0hA:
undetectable
3u9fO-4v0hA:
undetectable		 3u9fN-4v0hA:
20.63
3u9fO-4v0hA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		 4v0h METALLO-BETA-LACTAMA
SE DOMAIN-CONTAINING
PROTEIN 1 1
(Homo
sapiens) 		5 / 11 ARG A 220
HIS A 172
GLY A 194
SER A  46
GLY A 201
 None
FE  A1242 (-3.4A)
None
None
None
 1.49A 3v3oC-4v0hA:
undetectable		 3v3oC-4v0hA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 4v0h METALLO-BETA-LACTAMA
SE DOMAIN-CONTAINING
PROTEIN 1 1
(Homo
sapiens) 		5 / 10 HIS A 117
HIS A 119
ASP A 121
HIS A 172
HIS A 234
 FE  A1242 (-3.5A)
FE  A1242 (-3.4A)
FE  A1243 (-2.9A)
FE  A1242 (-3.4A)
FE  A1243 (-3.2A)
 0.66A 4c1dB-4v0hA:
7.3		 4c1dB-4v0hA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 4v0h METALLO-BETA-LACTAMA
SE DOMAIN-CONTAINING
PROTEIN 1 1
(Homo
sapiens) 		5 / 11 HIS A 117
HIS A 119
ASP A 121
HIS A 172
HIS A 234
 FE  A1242 (-3.5A)
FE  A1242 (-3.4A)
FE  A1243 (-2.9A)
FE  A1242 (-3.4A)
FE  A1243 (-3.2A)
 0.72A 4c1fA-4v0hA:
14.3
4c1fB-4v0hA:
6.0		 4c1fA-4v0hA:
21.55
4c1fB-4v0hA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 4v0h METALLO-BETA-LACTAMA
SE DOMAIN-CONTAINING
PROTEIN 1 1
(Homo
sapiens) 		5 / 9 HIS A 117
HIS A 119
ASP A 121
HIS A 172
HIS A 234
 FE  A1242 (-3.5A)
FE  A1242 (-3.4A)
FE  A1243 (-2.9A)
FE  A1242 (-3.4A)
FE  A1243 (-3.2A)
 0.64A 4c1hA-4v0hA:
5.8		 4c1hA-4v0hA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4v0h METALLO-BETA-LACTAMA
SE DOMAIN-CONTAINING
PROTEIN 1 1
(Homo
sapiens) 		5 / 10 GLY A 124
ASP A 121
GLY A  88
HIS A 117
HIS A 234
 None
FE  A1243 (-2.9A)
None
FE  A1242 (-3.5A)
FE  A1243 (-3.2A)
 1.11A 4c5nB-4v0hA:
undetectable		 4c5nB-4v0hA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 4v0h METALLO-BETA-LACTAMA
SE DOMAIN-CONTAINING
PROTEIN 1 1
(Homo
sapiens) 		4 / 8 HIS A 119
ASP A 121
HIS A 172
HIS A 234
 FE  A1242 (-3.4A)
FE  A1243 (-2.9A)
FE  A1242 (-3.4A)
FE  A1243 (-3.2A)
 0.65A 4exsB-4v0hA:
14.6		 4exsB-4v0hA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 4v0h METALLO-BETA-LACTAMA
SE DOMAIN-CONTAINING
PROTEIN 1 1
(Homo
sapiens) 		5 / 12 HIS A 172
HIS A 119
GLY A 118
ASP A 195
GLY A 194
 FE  A1242 (-3.4A)
FE  A1242 (-3.4A)
None
FE  A1243 ( 2.4A)
None
 1.32A 4qa0A-4v0hA:
undetectable		 4qa0A-4v0hA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 4v0h METALLO-BETA-LACTAMA
SE DOMAIN-CONTAINING
PROTEIN 1 1
(Homo
sapiens) 		4 / 8 HIS A 119
ASP A 121
HIS A 172
HIS A 234
 FE  A1242 (-3.4A)
FE  A1243 (-2.9A)
FE  A1242 (-3.4A)
FE  A1243 (-3.2A)
 0.68A 5a5zA-4v0hA:
15.2		 5a5zA-4v0hA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 4v0h METALLO-BETA-LACTAMA
SE DOMAIN-CONTAINING
PROTEIN 1 1
(Homo
sapiens) 		6 / 11 HIS A 117
HIS A 119
ASP A 121
HIS A 122
HIS A 172
HIS A 234
 FE  A1242 (-3.5A)
FE  A1242 (-3.4A)
FE  A1243 (-2.9A)
FE  A1243 (-3.5A)
FE  A1242 (-3.4A)
FE  A1243 (-3.2A)
 0.49A 5ayaA-4v0hA:
13.8		 5ayaA-4v0hA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 4v0h METALLO-BETA-LACTAMA
SE DOMAIN-CONTAINING
PROTEIN 1 1
(Homo
sapiens) 		5 / 12 ARG A  93
LEU A 128
VAL A 110
PHE A 129
GLY A  98
 None
 1.35A 5i8fA-4v0hA:
undetectable		 5i8fA-4v0hA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 4v0h METALLO-BETA-LACTAMA
SE DOMAIN-CONTAINING
PROTEIN 1 1
(Homo
sapiens) 		4 / 8 ASP A 195
HIS A 172
HIS A 117
HIS A 234
 FE  A1243 ( 2.4A)
FE  A1242 (-3.4A)
FE  A1242 (-3.5A)
FE  A1243 (-3.2A)
 0.92A 5nekD-4v0hA:
undetectable		 5nekD-4v0hA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4v0h METALLO-BETA-LACTAMA
SE DOMAIN-CONTAINING
PROTEIN 1 1
(Homo
sapiens) 		5 / 10 HIS A 117
HIS A 119
HIS A 122
HIS A 172
ASP A 195
 FE  A1242 (-3.5A)
FE  A1242 (-3.4A)
FE  A1243 (-3.5A)
FE  A1242 (-3.4A)
FE  A1243 ( 2.4A)
 0.29A 5nzwA-4v0hA:
4.0		 5nzwA-4v0hA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)		 4v0h METALLO-BETA-LACTAMA
SE DOMAIN-CONTAINING
PROTEIN 1 1
(Homo
sapiens) 		4 / 8 GLY A 115
GLN A 175
VAL A 178
ASP A 177
 None
 0.89A 5vlmA-4v0hA:
undetectable		 5vlmA-4v0hA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 4v0h METALLO-BETA-LACTAMA
SE DOMAIN-CONTAINING
PROTEIN 1 1
(Homo
sapiens) 		4 / 8 HIS A 119
ASP A 121
HIS A 172
HIS A 234
 FE  A1242 (-3.4A)
FE  A1243 (-2.9A)
FE  A1242 (-3.4A)
FE  A1243 (-3.2A)
 0.68A 5zj8A-4v0hA:
15.3		 5zj8A-4v0hA:
23.96