SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4v0k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4v0k ARF-LIKE SMALL
GTPASE
(Chlamydomonas
reinhardtii) 		4 / 6 LEU A 163
VAL A  20
VAL A  93
ILE A  34
 GDP  A 700 (-4.4A)
None
None
None
 0.85A 2hyyB-4v0kA:
undetectable		 2hyyB-4v0kA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4v0k ARF-LIKE SMALL
GTPASE
(Chlamydomonas
reinhardtii) 		4 / 6 LEU A 163
VAL A  20
VAL A  93
ILE A  34
 GDP  A 700 (-4.4A)
None
None
None
 0.87A 3k5vA-4v0kA:
undetectable		 3k5vA-4v0kA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4v0k ARF-LIKE SMALL
GTPASE
(Chlamydomonas
reinhardtii) 		3 / 3 THR A  64
ASN A  19
GLU A  57
 None
 0.65A 3v4tA-4v0kA:
undetectable
3v4tC-4v0kA:
undetectable		 3v4tA-4v0kA:
18.88
3v4tC-4v0kA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 4v0k ARF-LIKE SMALL
GTPASE
(Chlamydomonas
reinhardtii) 		4 / 8 ASP A  95
SER A  28
ASN A  27
GLY A 162
 None
GDP  A 700 (-3.1A)
GDP  A 700 (-4.2A)
GDP  A 700 (-3.7A)
 0.96A 4fo4A-4v0kA:
undetectable		 4fo4A-4v0kA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 4v0k ARF-LIKE SMALL
GTPASE
(Chlamydomonas
reinhardtii) 		5 / 12 ILE A 157
ASP A 148
ALA A 142
ILE A 141
SER A  96
 None
 1.09A 4uroC-4v0kA:
undetectable		 4uroC-4v0kA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_A_SAMA901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 4v0k ARF-LIKE SMALL
GTPASE
(Chlamydomonas
reinhardtii) 		5 / 12 PHE A 126
LEU A 163
VAL A  22
ARG A  36
ILE A  34
 None
GDP  A 700 (-4.4A)
None
None
None
 1.35A 6bxnA-4v0kA:
2.0		 6bxnA-4v0kA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 4v0k ARF-LIKE SMALL
GTPASE
(Chlamydomonas
reinhardtii) 		5 / 12 PHE A 126
LEU A 163
VAL A  22
ARG A  36
ILE A  34
 None
GDP  A 700 (-4.4A)
None
None
None
 1.39A 6bxnB-4v0kA:
undetectable		 6bxnB-4v0kA:
18.71