SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4v0n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 4v0n BARDET-BIEDL
SYNDROME 1 PROTEIN
(Chlamydomonas
reinhardtii) 		5 / 8 GLY B  67
ASN B  62
GLY B  65
HIS B  92
VAL B  72
 None
 1.44A 1dbbH-4v0nB:
undetectable
1dbbL-4v0nB:
undetectable		 1dbbH-4v0nB:
19.10
1dbbL-4v0nB:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 4v0n BARDET-BIEDL
SYNDROME 1 PROTEIN
(Chlamydomonas
reinhardtii) 		5 / 10 ILE B 124
ILE B 126
LEU B 235
ARG B 128
ILE B 246
 None
None
None
None
HG  B1433 ( 4.5A)
 1.17A 2nnhB-4v0nB:
undetectable		 2nnhB-4v0nB:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4v0n BARDET-BIEDL
SYNDROME 1 PROTEIN
(Chlamydomonas
reinhardtii) 		4 / 8 LEU B 418
PHE B 394
THR B 354
ALA B 361
 None
 0.85A 3ax9B-4v0nB:
undetectable		 3ax9B-4v0nB:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGX_A_SALA102_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 4v0n BARDET-BIEDL
SYNDROME 1 PROTEIN
(Chlamydomonas
reinhardtii) 		4 / 7 MET B 219
ILE B 124
TYR B 125
ILE B 126
 None
 0.78A 3hgxA-4v0nB:
undetectable		 3hgxA-4v0nB:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW4_A_TICA600_1
(CYTOCHROME P450 2B4)		 4v0n BARDET-BIEDL
SYNDROME 1 PROTEIN
(Chlamydomonas
reinhardtii) 		5 / 11 ILE B 244
ALA B 265
ILE B 262
VAL B 260
GLY B 242
 None
 0.92A 3kw4A-4v0nB:
undetectable		 3kw4A-4v0nB:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 4v0n BARDET-BIEDL
SYNDROME 1 PROTEIN
(Chlamydomonas
reinhardtii) 		4 / 7 ILE B 345
VAL B 364
ARG B 372
TYR B 374
 None
 0.92A 3p6hA-4v0nB:
undetectable		 3p6hA-4v0nB:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4v0n BARDET-BIEDL
SYNDROME 1 PROTEIN
(Chlamydomonas
reinhardtii) 		5 / 12 LEU B 296
GLU B 240
GLY B 261
ILE B 300
ARG B 284
 None
 1.17A 4hytA-4v0nB:
undetectable		 4hytA-4v0nB:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		 4v0n BARDET-BIEDL
SYNDROME 1 PROTEIN
(Chlamydomonas
reinhardtii) 		5 / 11 LEU B 418
VAL B 373
ILE B 363
PHE B 394
LEU B 392
 None
 1.42A 4lhmA-4v0nB:
undetectable		 4lhmA-4v0nB:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4v0n BARDET-BIEDL
SYNDROME 1 PROTEIN
(Chlamydomonas
reinhardtii) 		5 / 9 ALA B 347
ALA B 391
ALA B 406
SER B 385
ALA B 365
 None
 1.31A 4twdA-4v0nB:
undetectable
4twdB-4v0nB:
undetectable
4twdC-4v0nB:
undetectable
4twdD-4v0nB:
undetectable
4twdE-4v0nB:
undetectable		 4twdA-4v0nB:
21.30
4twdB-4v0nB:
21.30
4twdC-4v0nB:
21.30
4twdD-4v0nB:
21.30
4twdE-4v0nB:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4v0n BARDET-BIEDL
SYNDROME 1 PROTEIN
(Chlamydomonas
reinhardtii) 		3 / 3 ALA B 117
TYR B 127
PRO B  98
 None
 0.63A 4zdyA-4v0nB:
undetectable		 4zdyA-4v0nB:
22.18