SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4v12'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 4v12 MAOC LIKE DOMAIN
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 7 SER A 326
ALA A 324
TYR A 304
ALA A 293
 None
 1.00A 1k5qA-4v12A:
undetectable
1k5qB-4v12A:
undetectable		 1k5qA-4v12A:
19.13
1k5qB-4v12A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)		 4v12 MAOC LIKE DOMAIN
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 11 LEU A 242
ALA A 249
LYS A 250
ALA A 161
VAL A 165
 None
 1.23A 3e22B-4v12A:
undetectable		 3e22B-4v12A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_D_LOCD700_2
(TUBULIN BETA-2B
CHAIN)		 4v12 MAOC LIKE DOMAIN
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 11 LEU A 242
ALA A 249
LYS A 250
ALA A 161
VAL A 165
 None
 1.24A 3e22D-4v12A:
undetectable		 3e22D-4v12A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 4v12 MAOC LIKE DOMAIN
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 11 SER A 305
LEU A 263
GLY A 270
PHE A 271
TYR A  41
 BTB  A1344 (-2.7A)
None
None
None
None
 1.48A 4foxC-4v12A:
undetectable		 4foxC-4v12A:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4v12 MAOC LIKE DOMAIN
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE A 282
GLY A 280
ILE A 101
ASP A 105
HIS A 140
 None
 1.17A 4iv0B-4v12A:
undetectable		 4iv0B-4v12A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 4v12 MAOC LIKE DOMAIN
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A 268
ALA A 269
SER A 273
ILE A 331
SER A 326
 None
 1.13A 4rtpA-4v12A:
undetectable		 4rtpA-4v12A:
24.65