SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4v15'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 4v15 D-THREONINE ALDOLASE
(Achromobacter
xylosoxidans) 		4 / 4 HIS A  98
LEU A 112
LEU A 134
LEU A 169
 None
 1.19A 1a4lD-4v15A:
5.7		 1a4lD-4v15A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 4v15 D-THREONINE ALDOLASE
(Achromobacter
xylosoxidans) 		4 / 5 LEU A  31
GLU A  37
ALA A 254
LEU A 275
 None
 1.18A 1eta1-4v15A:
undetectable		 1eta1-4v15A:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 4v15 D-THREONINE ALDOLASE
(Achromobacter
xylosoxidans) 		4 / 5 LEU A  31
GLU A  37
ALA A 254
LEU A 275
 None
 1.17A 1eta2-4v15A:
undetectable		 1eta2-4v15A:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 4v15 D-THREONINE ALDOLASE
(Achromobacter
xylosoxidans) 		4 / 6 LEU A  31
GLU A  37
ALA A 254
LEU A 275
 None
 1.15A 1etb1-4v15A:
undetectable		 1etb1-4v15A:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_2_BO221405_1
(PROTEASOME COMPONENT
PRE3)		 4v15 D-THREONINE ALDOLASE
(Achromobacter
xylosoxidans) 		5 / 11 THR A 233
ALA A  47
SER A 252
GLY A 251
SER A 235
 PLP  A1380 (-3.6A)
None
PLP  A1381 (-2.6A)
PLP  A1381 (-3.5A)
None
 0.85A 2f162-4v15A:
undetectable		 2f162-4v15A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 4v15 D-THREONINE ALDOLASE
(Achromobacter
xylosoxidans) 		5 / 11 THR A 233
ALA A  47
SER A 252
GLY A 251
SER A 235
 PLP  A1380 (-3.6A)
None
PLP  A1381 (-2.6A)
PLP  A1381 (-3.5A)
None
 0.85A 2f16N-4v15A:
undetectable		 2f16N-4v15A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4v15 D-THREONINE ALDOLASE
(Achromobacter
xylosoxidans) 		5 / 10 LEU A 112
GLY A 113
LEU A 109
LEU A 179
ILE A 145
 None
 1.04A 2f8dB-4v15A:
undetectable		 2f8dB-4v15A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		 4v15 D-THREONINE ALDOLASE
(Achromobacter
xylosoxidans) 		4 / 5 LEU A  54
ARG A  76
ASP A  48
ALA A  47
 None
 1.00A 2qhfA-4v15A:
undetectable		 2qhfA-4v15A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		 4v15 D-THREONINE ALDOLASE
(Achromobacter
xylosoxidans) 		5 / 12 LEU A 292
ASP A 293
SER A 298
HIS A 355
ALA A 294
 None
 1.27A 3d91A-4v15A:
undetectable		 3d91A-4v15A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 4v15 D-THREONINE ALDOLASE
(Achromobacter
xylosoxidans) 		5 / 11 ALA A 119
ILE A  97
LEU A 115
LEU A  87
ALA A  86
 None
 1.01A 3kw2A-4v15A:
undetectable		 3kw2A-4v15A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 4v15 D-THREONINE ALDOLASE
(Achromobacter
xylosoxidans) 		5 / 11 ALA A 119
ILE A  97
LEU A 115
LEU A  87
ALA A  86
 None
 1.01A 3kw2B-4v15A:
undetectable		 3kw2B-4v15A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 4v15 D-THREONINE ALDOLASE
(Achromobacter
xylosoxidans) 		5 / 11 ARG A  95
ILE A  78
GLY A  77
LEU A  68
ALA A  67
 None
 1.17A 3kw2B-4v15A:
undetectable		 3kw2B-4v15A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_2_BO221405_1
(PROTEASOME COMPONENT
PRE3
PROTEASOME COMPONENT
PUP1)		 4v15 D-THREONINE ALDOLASE
(Achromobacter
xylosoxidans) 		5 / 12 THR A 233
ALA A  47
SER A 252
GLY A 251
SER A 235
 PLP  A1380 (-3.6A)
None
PLP  A1381 (-2.6A)
PLP  A1381 (-3.5A)
None
 0.88A 3mg02-4v15A:
undetectable
3mg0V-4v15A:
undetectable		 3mg02-4v15A:
17.87
3mg0V-4v15A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 4v15 D-THREONINE ALDOLASE
(Achromobacter
xylosoxidans) 		5 / 11 THR A 233
ALA A  47
SER A 252
GLY A 251
SER A 235
 PLP  A1380 (-3.6A)
None
PLP  A1381 (-2.6A)
PLP  A1381 (-3.5A)
None
 0.87A 3mg0N-4v15A:
undetectable		 3mg0N-4v15A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4v15 D-THREONINE ALDOLASE
(Achromobacter
xylosoxidans) 		3 / 3 TYR A 187
GLY A 231
ASP A 239
 PLP  A1380 (-3.5A)
None
None
 0.59A 3ou6C-4v15A:
undetectable		 3ou6C-4v15A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD507_1
(HEMOLYTIC LECTIN
CEL-III)		 4v15 D-THREONINE ALDOLASE
(Achromobacter
xylosoxidans) 		4 / 5 GLU A 150
GLY A 159
TYR A 214
ASP A 162
 None
 1.37A 3w9tD-4v15A:
undetectable		 3w9tD-4v15A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 4v15 D-THREONINE ALDOLASE
(Achromobacter
xylosoxidans) 		4 / 7 LEU A 248
TYR A 245
ASP A 239
SER A 235
 None
 1.25A 4arcA-4v15A:
undetectable		 4arcA-4v15A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4v15 D-THREONINE ALDOLASE
(Achromobacter
xylosoxidans) 		3 / 3 SER A 252
TYR A 260
PRO A  56
 PLP  A1381 (-2.6A)
PLP  A1380 (-4.4A)
None
 0.87A 4kanA-4v15A:
undetectable		 4kanA-4v15A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 4v15 D-THREONINE ALDOLASE
(Achromobacter
xylosoxidans) 		3 / 3 TYR A 245
GLN A 192
TRP A  46
 None
PLP  A1380 ( 4.9A)
None
 0.99A 4kn2C-4v15A:
undetectable		 4kn2C-4v15A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4v15 D-THREONINE ALDOLASE
(Achromobacter
xylosoxidans) 		3 / 3 SER A 252
TYR A 260
PRO A  56
 PLP  A1381 (-2.6A)
PLP  A1380 (-4.4A)
None
 0.85A 4lbgA-4v15A:
undetectable		 4lbgA-4v15A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4v15 D-THREONINE ALDOLASE
(Achromobacter
xylosoxidans) 		5 / 10 ALA A 137
VAL A 123
ALA A 116
ALA A 143
ILE A 145
 None
 1.03A 4lbgA-4v15A:
undetectable		 4lbgA-4v15A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4v15 D-THREONINE ALDOLASE
(Achromobacter
xylosoxidans) 		3 / 3 SER A 252
TYR A 260
PRO A  56
 PLP  A1381 (-2.6A)
PLP  A1380 (-4.4A)
None
 0.85A 4lbgB-4v15A:
undetectable		 4lbgB-4v15A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA601_1
(SERUM ALBUMIN)		 4v15 D-THREONINE ALDOLASE
(Achromobacter
xylosoxidans) 		5 / 11 ASN A 127
VAL A 160
GLY A 159
CYH A 158
LEU A 169
 None
 1.43A 4or0A-4v15A:
undetectable		 4or0A-4v15A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA601_1
(SERUM ALBUMIN)		 4v15 D-THREONINE ALDOLASE
(Achromobacter
xylosoxidans) 		5 / 12 ASN A 127
VAL A 160
GLY A 159
CYH A 158
LEU A 169
 None
 1.43A 4ot2A-4v15A:
undetectable		 4ot2A-4v15A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 4v15 D-THREONINE ALDOLASE
(Achromobacter
xylosoxidans) 		5 / 12 PRO A  56
ARG A  69
LEU A 248
MET A  43
ALA A  47
 None
 1.16A 5h5fA-4v15A:
undetectable		 5h5fA-4v15A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 4v15 D-THREONINE ALDOLASE
(Achromobacter
xylosoxidans) 		4 / 6 PRO A 306
LEU A  29
PHE A 276
LEU A 278
 None
 1.03A 5tl8A-4v15A:
undetectable		 5tl8A-4v15A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA606_1
(SERUM ALBUMIN)		 4v15 D-THREONINE ALDOLASE
(Achromobacter
xylosoxidans) 		5 / 12 ASN A 127
VAL A 160
GLY A 159
CYH A 158
LEU A 169
 None
 1.47A 6ci6A-4v15A:
undetectable		 6ci6A-4v15A:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_0
(ADENOSYLHOMOCYSTEINA
SE)		 4v15 D-THREONINE ALDOLASE
(Achromobacter
xylosoxidans) 		5 / 12 HIS A 347
THR A 300
THR A 351
HIS A 193
GLY A 304
 MN  A1382 (-3.4A)
None
None
None
None
 1.45A 6exiA-4v15A:
undetectable		 6exiA-4v15A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_0
(ADENOSYLHOMOCYSTEINA
SE)		 4v15 D-THREONINE ALDOLASE
(Achromobacter
xylosoxidans) 		5 / 12 HIS A 347
THR A 300
THR A 351
HIS A 193
GLY A 304
 MN  A1382 (-3.4A)
None
None
None
None
 1.45A 6exiD-4v15A:
undetectable		 6exiD-4v15A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_2
(GLUCOAMYLASE P)		 4v15 D-THREONINE ALDOLASE
(Achromobacter
xylosoxidans) 		3 / 3 TRP A 265
GLU A 264
GLU A 237
 None
 0.81A 6fhwA-4v15A:
undetectable		 6fhwA-4v15A:
13.51