SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4v16'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4v16 SVP1-LIKE PROTEIN 2
(Kluyveromyces
lactis) 		5 / 10 TYR A  20
PHE A 316
LEU A 284
VAL A 286
VAL A 242
 None
 1.31A 1q23K-4v16A:
undetectable		 1q23K-4v16A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4v16 SVP1-LIKE PROTEIN 2
(Kluyveromyces
lactis) 		5 / 12 LEU A  45
ILE A  17
VAL A 306
ALA A 313
TYR A  40
 None
 1.22A 2japA-4v16A:
undetectable		 2japA-4v16A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4v16 SVP1-LIKE PROTEIN 2
(Kluyveromyces
lactis) 		5 / 12 LEU A  45
ILE A  17
VAL A 306
ALA A 313
TYR A  40
 None
 1.21A 2japB-4v16A:
undetectable		 2japB-4v16A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4v16 SVP1-LIKE PROTEIN 2
(Kluyveromyces
lactis) 		5 / 12 LEU A  45
ILE A  17
VAL A 306
ALA A 313
TYR A  40
 None
 1.23A 2japC-4v16A:
undetectable		 2japC-4v16A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4v16 SVP1-LIKE PROTEIN 2
(Kluyveromyces
lactis) 		5 / 12 LEU A  45
ILE A  17
VAL A 306
ALA A 313
TYR A  40
 None
 1.23A 2japD-4v16A:
undetectable		 2japD-4v16A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 4v16 SVP1-LIKE PROTEIN 2
(Kluyveromyces
lactis) 		4 / 6 LEU A 284
ARG A 334
PHE A 316
LEU A 303
 None
 1.14A 2wm3A-4v16A:
undetectable		 2wm3A-4v16A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGX_A_SALA102_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 4v16 SVP1-LIKE PROTEIN 2
(Kluyveromyces
lactis) 		4 / 7 MET A  61
ILE A  39
TYR A  40
ILE A  48
 None
 0.96A 3hgxA-4v16A:
undetectable		 3hgxA-4v16A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4v16 SVP1-LIKE PROTEIN 2
(Kluyveromyces
lactis) 		4 / 7 ARG A  47
GLU A 336
ILE A 337
ASN A  15
 None
 1.07A 4d39B-4v16A:
undetectable		 4d39B-4v16A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_A_H4BA804_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4v16 SVP1-LIKE PROTEIN 2
(Kluyveromyces
lactis) 		4 / 7 ARG A 220
TRP A 277
PHE A 251
GLU A 217
 None
 1.30A 4jseA-4v16A:
undetectable
4jseB-4v16A:
undetectable		 4jseA-4v16A:
24.69
4jseB-4v16A:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4v16 SVP1-LIKE PROTEIN 2
(Kluyveromyces
lactis) 		4 / 5 LEU A 248
ARG A 231
PRO A 308
SER A 290
 None
 1.36A 4kmmB-4v16A:
undetectable		 4kmmB-4v16A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 4v16 SVP1-LIKE PROTEIN 2
(Kluyveromyces
lactis) 		3 / 3 ILE A  59
MET A  49
ARG A  47
 None
 0.96A 4lnxA-4v16A:
undetectable		 4lnxA-4v16A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAE_A_NIZA804_1
(CATALASE-PEROXIDASE)		 4v16 SVP1-LIKE PROTEIN 2
(Kluyveromyces
lactis) 		4 / 6 PHE A 121
LEU A 103
HIS A  63
THR A  65
 None
 1.17A 4paeA-4v16A:
undetectable		 4paeA-4v16A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4v16 SVP1-LIKE PROTEIN 2
(Kluyveromyces
lactis) 		4 / 6 ARG A 220
CYH A 197
ILE A 204
ASP A 244
 None
 1.16A 4w5tA-4v16A:
undetectable		 4w5tA-4v16A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4v16 SVP1-LIKE PROTEIN 2
(Kluyveromyces
lactis) 		4 / 6 ARG A 220
CYH A 197
ILE A 204
ASP A 244
 None
 1.15A 4z4cA-4v16A:
undetectable		 4z4cA-4v16A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4v16 SVP1-LIKE PROTEIN 2
(Kluyveromyces
lactis) 		4 / 6 ARG A 220
CYH A 197
ILE A 204
ASP A 244
 None
 1.16A 4z4dA-4v16A:
undetectable		 4z4dA-4v16A:
17.04