SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4v19'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D8C_A_SORA4000_0
(MALATE SYNTHASE G)		 4v19 MITORIBOSOMAL
PROTEIN UL29M,
MRPL47
(Sus
scrofa) 		3 / 3 GLN 2 237
HIS 2 242
PRO 2 241
 None
 0.90A 1d8cA-4v192:
2.1		 1d8cA-4v192:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4v19 MITORIBOSOMAL
PROTEIN BL28M,
MRPL28
(Sus
scrofa) 		5 / 12 THR 1 148
ARG 1 130
LEU 1 134
TYR 1 144
GLY 1  82
 None
 1.23A 1httB-4v191:
undetectable		 1httB-4v191:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 4v19 MITORIBOSOMAL
PROTEIN BL28M,
MRPL28
(Sus
scrofa) 		4 / 8 GLU 1  83
GLY 1  81
ILE 1 135
LEU 1 132
 None
 0.84A 1jg4A-4v191:
undetectable		 1jg4A-4v191:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 4v19 MITORIBOSOMAL
PROTEIN BL28M,
MRPL28
(Sus
scrofa) 		4 / 6 VAL 1 125
THR 1 124
LEU 1 114
ARG 1 122
 None
 1.09A 1s8fB-4v191:
undetectable		 1s8fB-4v191:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		 4v19 MITORIBOSOMAL
PROTEIN UL29M,
MRPL47
(Sus
scrofa) 		4 / 4 ASP 2 153
LEU 2 158
LEU 2 155
LEU 2 157
 None
 1.41A 1u18A-4v192:
undetectable		 1u18A-4v192:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE509_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4v19 MITORIBOSOMAL
PROTEIN BL32M,
MRPL32
(Sus
scrofa) 		4 / 6 ASP 5 169
GLU 5 155
ARG 5 173
LYS 5 172
 None
 1.32A 1yc2A-4v195:
undetectable
1yc2B-4v195:
undetectable
1yc2E-4v195:
undetectable		 1yc2A-4v195:
20.23
1yc2B-4v195:
20.23
1yc2E-4v195:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 4v19 MITORIBOSOMAL
PROTEIN BL32M,
MRPL32
(Sus
scrofa) 		4 / 6 GLU 5 163
TYR 5 160
SER 5 166
GLN 5 168
 None
 1.38A 2cl5B-4v195:
undetectable		 2cl5B-4v195:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)		 4v19 MITORIBOSOMAL
PROTEIN UL2M, MRPL2
(Sus
scrofa) 		4 / 5 LEU D 229
LEU D 218
CYH D 214
THR D 213
 G  A 849 ( 4.1A)
None
None
A  A 860 ( 3.8A)
 0.90A 2oaxD-4v19D:
undetectable		 2oaxD-4v19D:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4v19 MITORIBOSOMAL
PROTEIN UL2M, MRPL2
(Sus
scrofa) 		3 / 3 VAL D 251
ASP D 252
GLU D 156
 U  A 861 ( 4.4A)
None
None
 0.75A 2qeuA-4v19D:
undetectable		 2qeuA-4v19D:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4v19 MITORIBOSOMAL
PROTEIN UL2M, MRPL2
(Sus
scrofa) 		3 / 3 VAL D 251
ASP D 252
GLU D 156
 U  A 861 ( 4.4A)
None
None
 0.73A 2qeuC-4v19D:
undetectable		 2qeuC-4v19D:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_G_BEZG1222_0
(PEROXIREDOXIN 6.)		 4v19 MITORIBOSOMAL
PROTEIN BL28M,
MRPL28
(Sus
scrofa) 		4 / 8 THR 1  39
PRO 1  40
VAL 1  41
ARG 1 130
 None
 1.12A 2v41G-4v191:
undetectable
2v41H-4v191:
undetectable		 2v41G-4v191:
20.36
2v41H-4v191:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 4v19 MITORIBOSOMAL
PROTEIN BL32M,
MRPL32
(Sus
scrofa) 		4 / 6 GLU 5 163
TYR 5 160
SER 5 166
GLN 5 168
 None
 1.26A 2zvjA-4v195:
undetectable		 2zvjA-4v195:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA2_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 4v19 MITORIBOSOMAL
PROTEIN BL33M,
MRPL33
(Sus
scrofa) 		3 / 3 LYS 6  33
LYS 6  60
VAL 6  18
 None
 1.07A 3brfA-4v196:
undetectable		 3brfA-4v196:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD302_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4v19 MITORIBOSOMAL
PROTEIN UL2M, MRPL2
(Sus
scrofa) 		3 / 3 TYR D 104
PHE D 109
ARG D 136
 A  A 857 ( 3.8A)
None
G  A 858 ( 3.3A)
 1.24A 4g19D-4v19D:
undetectable		 4g19D-4v19D:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 4v19 MITORIBOSOMAL
PROTEIN BL31M,
MRPL55
(Sus
scrofa) 		5 / 12 ARG 4  73
LEU 4  57
VAL 4  55
ILE 4  67
LEU 4  52
 None
 1.25A 4k36A-4v194:
undetectable		 4k36A-4v194:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 4v19 MITORIBOSOMAL
PROTEIN BL31M,
MRPL55
(Sus
scrofa) 		5 / 12 ARG 4  73
LEU 4  57
VAL 4  55
ILE 4  67
LEU 4  52
 None
 1.25A 4k36B-4v194:
undetectable		 4k36B-4v194:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K37_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 4v19 MITORIBOSOMAL
PROTEIN BL31M,
MRPL55
(Sus
scrofa) 		5 / 11 ARG 4  73
LEU 4  57
VAL 4  55
ILE 4  67
LEU 4  52
 None
 1.30A 4k37A-4v194:
undetectable		 4k37A-4v194:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K37_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 4v19 MITORIBOSOMAL
PROTEIN BL31M,
MRPL55
(Sus
scrofa) 		5 / 11 ARG 4  73
LEU 4  57
VAL 4  55
ILE 4  67
LEU 4  52
 None
 1.23A 4k37B-4v194:
undetectable		 4k37B-4v194:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME
KP18CYS PEPTIDE)		 4v19 MITORIBOSOMAL
PROTEIN BL31M,
MRPL55
(Sus
scrofa) 		5 / 12 ARG 4  73
LEU 4  57
VAL 4  55
ILE 4  67
LEU 4  52
 None
 1.30A 4k38A-4v194:
undetectable
4k38D-4v194:
undetectable		 4k38A-4v194:
14.86
4k38D-4v194:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 4v19 MITORIBOSOMAL
PROTEIN BL31M,
MRPL55
(Sus
scrofa) 		5 / 12 ARG 4  73
LEU 4  57
VAL 4  55
ILE 4  67
LEU 4  52
 None
 1.30A 4k38B-4v194:
undetectable		 4k38B-4v194:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 4v19 MITORIBOSOMAL
PROTEIN BL31M,
MRPL55
(Sus
scrofa) 		5 / 12 ARG 4  73
LEU 4  57
VAL 4  55
ILE 4  67
LEU 4  52
 None
 1.24A 4k39A-4v194:
undetectable		 4k39A-4v194:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4v19 MITORIBOSOMAL
PROTEIN BL27M,
MRPL27
(Sus
scrofa) 		3 / 3 VAL 0  61
HIS 0 132
VAL 0  81
 None
 0.58A 5jmnC-4v190:
undetectable		 5jmnC-4v190:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4v19 MITORIBOSOMAL
PROTEIN UL30M,
MRPL30
(Sus
scrofa) 		3 / 3 LYS 3 120
PRO 3 121
LYS 3 123
 None
 1.29A 5y9yA-4v193:
undetectable		 5y9yA-4v193:
19.22