SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4v1d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_A_MTXA301_1
(PTERIDINE REDUCTASE)
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, HEAVY CHAIN

(Homo
sapiens)
5 / 12 PRO D  41
LEU D 119
LEU D  18
LEU D  86
ASP D  90
None
1.14A 1e7wA-4v1dD:
undetectable
1e7wA-4v1dD:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo
sapiens)
4 / 7 VAL E 157
ILE E 215
GLU E 221
LEU E 179
None
0.91A 1j96B-4v1dE:
undetectable
1j96B-4v1dE:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5L_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, HEAVY CHAIN

(Homo
sapiens)
5 / 9 GLY D 117
LEU D  20
GLU D   6
ARG D 116
GLY D   8
None
1.30A 1l5lA-4v1dD:
undetectable
1l5lA-4v1dD:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, HEAVY CHAIN

(Homo
sapiens)
5 / 9 GLY D 117
LEU D  20
GLU D   6
ARG D 116
GLY D   8
None
1.26A 1l5mA-4v1dD:
undetectable
1l5mA-4v1dD:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_A_CAMA1422_0
(CYTOCHROME P450-CAM)
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, HEAVY CHAIN
SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo
sapiens;
Homo
sapiens)
4 / 7 PHE D 111
GLY E 237
VAL D  50
ASP D  99
None
1.01A 1t88A-4v1dD:
undetectable
1t88A-4v1dD:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo
sapiens)
4 / 7 VAL E 248
ARG E 201
VAL E 157
GLU E 223
None
1.09A 1zzrA-4v1dE:
undetectable
1zzrB-4v1dE:
undetectable
1zzrA-4v1dE:
14.73
1zzrB-4v1dE:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo
sapiens)
4 / 7 GLU E 223
VAL E 248
ARG E 201
VAL E 157
None
1.08A 1zzrA-4v1dE:
undetectable
1zzrB-4v1dE:
undetectable
1zzrA-4v1dE:
14.73
1zzrB-4v1dE:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo
sapiens)
4 / 7 VAL E 248
ARG E 201
VAL E 157
GLU E 223
None
1.07A 1zzuA-4v1dE:
undetectable
1zzuB-4v1dE:
undetectable
1zzuA-4v1dE:
14.73
1zzuB-4v1dE:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo
sapiens)
4 / 7 GLU E 223
VAL E 248
ARG E 201
VAL E 157
None
1.08A 1zzuA-4v1dE:
undetectable
1zzuB-4v1dE:
undetectable
1zzuA-4v1dE:
14.73
1zzuB-4v1dE:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo
sapiens)
4 / 8 SER E 170
ASP E 233
SER E 166
SER E 165
None
1.12A 2cmlC-4v1dE:
undetectable
2cmlC-4v1dE:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo
sapiens)
4 / 8 SER E 170
ASP E 233
SER E 166
SER E 165
None
1.12A 2cmlD-4v1dE:
undetectable
2cmlD-4v1dE:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, HEAVY CHAIN
SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo
sapiens;
Homo
sapiens)
4 / 7 TYR D  95
TYR E 176
PRO E 184
TYR E 227
None
0.47A 2oldA-4v1dD:
13.6
2oldB-4v1dD:
13.8
2oldA-4v1dD:
19.28
2oldB-4v1dD:
19.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, HEAVY CHAIN
SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo
sapiens;
Homo
sapiens)
5 / 7 TYR E 176
HIS E 178
PRO E 184
TYR E 227
TYR D  95
None
0.49A 2oldA-4v1dE:
20.0
2oldB-4v1dE:
20.2
2oldA-4v1dE:
33.19
2oldB-4v1dE:
33.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OMB_D_IPHD2002_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo
sapiens)
4 / 7 TYR E 176
HIS E 178
PRO E 184
TYR E 227
None
0.40A 2ombC-4v1dE:
19.7
2ombD-4v1dE:
19.9
2ombC-4v1dE:
33.19
2ombD-4v1dE:
33.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OMB_D_IPHD2002_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, HEAVY CHAIN
SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo
sapiens;
Homo
sapiens)
4 / 7 TYR E 176
HIS E 178
PRO E 184
TYR D  95
None
0.78A 2ombC-4v1dE:
19.7
2ombD-4v1dE:
19.9
2ombC-4v1dE:
33.19
2ombD-4v1dE:
33.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo
sapiens)
4 / 8 LEU E 179
VAL E 248
ILE E 215
PHE E 202
None
0.89A 2weyB-4v1dE:
undetectable
2weyB-4v1dE:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, HEAVY CHAIN
SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo
sapiens)
3 / 3 ASP D  99
PHE D 111
LEU E 186
None
0.72A 2zi9A-4v1dD:
undetectable
2zi9A-4v1dD:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo
sapiens)
4 / 7 VAL E 248
ARG E 201
VAL E 157
GLU E 223
None
1.11A 3dqrA-4v1dE:
undetectable
3dqrB-4v1dE:
undetectable
3dqrA-4v1dE:
14.76
3dqrB-4v1dE:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo
sapiens)
4 / 7 GLU E 223
VAL E 248
ARG E 201
VAL E 157
None
1.15A 3dqrA-4v1dE:
undetectable
3dqrB-4v1dE:
undetectable
3dqrA-4v1dE:
14.76
3dqrB-4v1dE:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_0
(PUTATIVE RRNA
METHYLASE)
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo
sapiens)
5 / 12 GLY E 237
ASP E 233
GLY E 241
GLN E 145
ASN E 171
None
1.14A 3eeyC-4v1dE:
undetectable
3eeyC-4v1dE:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_0
(PUTATIVE RRNA
METHYLASE)
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo
sapiens)
5 / 12 GLY E 237
ASP E 233
GLY E 241
GLN E 145
ASN E 171
None
1.14A 3eeyD-4v1dE:
undetectable
3eeyD-4v1dE:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_0
(PUTATIVE RRNA
METHYLASE)
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo
sapiens)
5 / 12 GLY E 237
ASP E 233
GLY E 241
GLN E 145
ASN E 171
None
1.13A 3eeyE-4v1dE:
undetectable
3eeyE-4v1dE:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_F_SAMF300_0
(PUTATIVE RRNA
METHYLASE)
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo
sapiens)
5 / 12 GLY E 237
ASP E 233
GLY E 241
GLN E 145
ASN E 171
None
1.11A 3eeyF-4v1dE:
undetectable
3eeyF-4v1dE:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_H_SAMH300_0
(PUTATIVE RRNA
METHYLASE)
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo
sapiens)
5 / 12 GLY E 237
ASP E 233
GLY E 241
GLN E 145
ASN E 171
None
1.13A 3eeyH-4v1dE:
undetectable
3eeyH-4v1dE:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_I_SAMI300_0
(PUTATIVE RRNA
METHYLASE)
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo
sapiens)
5 / 12 GLY E 237
ASP E 233
GLY E 241
GLN E 145
ASN E 171
None
1.13A 3eeyI-4v1dE:
undetectable
3eeyI-4v1dE:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_J_SAMJ300_0
(PUTATIVE RRNA
METHYLASE)
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo
sapiens)
5 / 12 GLY E 237
ASP E 233
GLY E 241
GLN E 145
ASN E 171
None
1.10A 3eeyJ-4v1dE:
undetectable
3eeyJ-4v1dE:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo
sapiens)
4 / 7 VAL E 248
ARG E 201
VAL E 157
GLU E 223
None
1.07A 3jx2A-4v1dE:
undetectable
3jx2B-4v1dE:
undetectable
3jx2A-4v1dE:
14.76
3jx2B-4v1dE:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo
sapiens)
4 / 7 GLU E 223
VAL E 248
ARG E 201
VAL E 157
None
1.07A 3jx2A-4v1dE:
undetectable
3jx2B-4v1dE:
undetectable
3jx2A-4v1dE:
14.76
3jx2B-4v1dE:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo
sapiens)
4 / 7 VAL E 248
ARG E 201
VAL E 157
GLU E 223
None
1.09A 3jx3A-4v1dE:
undetectable
3jx3B-4v1dE:
undetectable
3jx3A-4v1dE:
14.76
3jx3B-4v1dE:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo
sapiens)
4 / 7 GLU E 223
VAL E 248
ARG E 201
VAL E 157
None
1.06A 3jx3A-4v1dE:
undetectable
3jx3B-4v1dE:
undetectable
3jx3A-4v1dE:
14.76
3jx3B-4v1dE:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo
sapiens)
4 / 7 GLU E 223
VAL E 248
ARG E 201
VAL E 157
None
1.09A 3jx4A-4v1dE:
undetectable
3jx4B-4v1dE:
undetectable
3jx4A-4v1dE:
14.76
3jx4B-4v1dE:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo
sapiens)
4 / 7 VAL E 248
ARG E 201
VAL E 157
GLU E 223
None
1.06A 3jx5A-4v1dE:
undetectable
3jx5B-4v1dE:
undetectable
3jx5A-4v1dE:
14.76
3jx5B-4v1dE:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo
sapiens)
4 / 7 GLU E 223
VAL E 248
ARG E 201
VAL E 157
None
1.08A 3jx5A-4v1dE:
undetectable
3jx5B-4v1dE:
undetectable
3jx5A-4v1dE:
14.76
3jx5B-4v1dE:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo
sapiens)
4 / 7 VAL E 248
ARG E 201
VAL E 157
GLU E 223
None
1.03A 3jx6A-4v1dE:
undetectable
3jx6B-4v1dE:
undetectable
3jx6A-4v1dE:
14.76
3jx6B-4v1dE:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo
sapiens)
4 / 7 GLU E 223
VAL E 248
ARG E 201
VAL E 157
None
1.03A 3jx6A-4v1dE:
undetectable
3jx6B-4v1dE:
undetectable
3jx6A-4v1dE:
14.76
3jx6B-4v1dE:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo
sapiens)
4 / 7 VAL E 248
ARG E 201
VAL E 157
GLU E 223
None
1.03A 3nljA-4v1dE:
undetectable
3nljB-4v1dE:
undetectable
3nljA-4v1dE:
14.76
3nljB-4v1dE:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo
sapiens)
4 / 7 GLU E 223
VAL E 248
ARG E 201
VAL E 157
None
1.04A 3nljA-4v1dE:
undetectable
3nljB-4v1dE:
undetectable
3nljA-4v1dE:
14.76
3nljB-4v1dE:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo
sapiens)
4 / 7 VAL E 248
ARG E 201
VAL E 157
GLU E 223
None
1.05A 3nlpA-4v1dE:
undetectable
3nlpB-4v1dE:
undetectable
3nlpA-4v1dE:
14.76
3nlpB-4v1dE:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo
sapiens)
4 / 7 GLU E 223
VAL E 248
ARG E 201
VAL E 157
None
1.09A 3nlpA-4v1dE:
undetectable
3nlpB-4v1dE:
undetectable
3nlpA-4v1dE:
14.76
3nlpB-4v1dE:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo
sapiens)
4 / 8 VAL E 248
ARG E 201
VAL E 157
GLU E 223
None
1.00A 3nlqA-4v1dE:
undetectable
3nlqB-4v1dE:
undetectable
3nlqA-4v1dE:
14.76
3nlqB-4v1dE:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo
sapiens)
4 / 7 GLU E 223
VAL E 248
ARG E 201
VAL E 157
None
1.01A 3nlqA-4v1dE:
undetectable
3nlqB-4v1dE:
undetectable
3nlqA-4v1dE:
14.76
3nlqB-4v1dE:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo
sapiens)
4 / 7 VAL E 248
ARG E 201
VAL E 157
GLU E 223
None
1.03A 3nlrA-4v1dE:
undetectable
3nlrB-4v1dE:
undetectable
3nlrA-4v1dE:
14.76
3nlrB-4v1dE:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo
sapiens)
4 / 8 GLU E 223
VAL E 248
ARG E 201
VAL E 157
None
1.05A 3nlrA-4v1dE:
undetectable
3nlrB-4v1dE:
undetectable
3nlrA-4v1dE:
14.76
3nlrB-4v1dE:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo
sapiens)
4 / 7 VAL E 248
ARG E 201
VAL E 157
GLU E 223
None
1.10A 4cx3A-4v1dE:
undetectable
4cx3B-4v1dE:
undetectable
4cx3A-4v1dE:
14.76
4cx3B-4v1dE:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo
sapiens)
4 / 7 GLU E 223
VAL E 248
ARG E 201
VAL E 157
None
1.08A 4cx3A-4v1dE:
undetectable
4cx3B-4v1dE:
undetectable
4cx3A-4v1dE:
14.76
4cx3B-4v1dE:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo
sapiens)
4 / 7 VAL E 248
ARG E 201
VAL E 157
GLU E 223
None
1.11A 4cx4A-4v1dE:
undetectable
4cx4B-4v1dE:
undetectable
4cx4A-4v1dE:
14.76
4cx4B-4v1dE:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo
sapiens)
4 / 7 GLU E 223
VAL E 248
ARG E 201
VAL E 157
None
1.08A 4cx4A-4v1dE:
undetectable
4cx4B-4v1dE:
undetectable
4cx4A-4v1dE:
14.76
4cx4B-4v1dE:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, HEAVY CHAIN
SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo
sapiens;
Homo
sapiens)
5 / 12 ILE E 188
GLN E 145
TYR E 226
GLN D  39
LEU D  45
None
1.24A 4qztA-4v1dE:
undetectable
4qztA-4v1dE:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo
sapiens)
4 / 7 GLU E 223
VAL E 248
ARG E 201
VAL E 157
None
1.00A 5addA-4v1dE:
undetectable
5addB-4v1dE:
undetectable
5addA-4v1dE:
14.76
5addB-4v1dE:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo
sapiens)
4 / 7 GLU E 223
VAL E 248
ARG E 201
VAL E 157
None
0.98A 5adeA-4v1dE:
undetectable
5adeB-4v1dE:
undetectable
5adeA-4v1dE:
14.76
5adeB-4v1dE:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo
sapiens)
4 / 7 VAL E 248
ARG E 201
VAL E 157
GLU E 223
None
1.08A 5g0pA-4v1dE:
undetectable
5g0pB-4v1dE:
undetectable
5g0pA-4v1dE:
14.76
5g0pB-4v1dE:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo
sapiens)
4 / 7 GLU E 223
VAL E 248
ARG E 201
VAL E 157
None
1.08A 5g0pA-4v1dE:
undetectable
5g0pB-4v1dE:
undetectable
5g0pA-4v1dE:
14.76
5g0pB-4v1dE:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, HEAVY CHAIN

(Homo
sapiens)
4 / 4 VAL D  50
GLY D  33
ASP D  99
ASP D 102
None
1.30A 6cjkC-4v1dD:
14.9
6cjkC-4v1dD:
20.66