SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4v1r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)		 4v1r ALPHA-1,6-MANNANASE
(Bacteroides
thetaiotaomicron) 		3 / 3 ASP A 328
ASP A 330
ASP A 321
 None
 0.75A 1eizA-4v1rA:
undetectable		 1eizA-4v1rA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)		 4v1r ALPHA-1,6-MANNANASE
(Bacteroides
thetaiotaomicron) 		4 / 7 THR A 202
ALA A 206
LEU A 210
SER A 211
 None
 0.86A 1tyrB-4v1rA:
undetectable		 1tyrB-4v1rA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)		 4v1r ALPHA-1,6-MANNANASE
(Bacteroides
thetaiotaomicron) 		3 / 3 THR A 129
GLU A 191
HIS A 118
 None
 0.90A 1xwfA-4v1rA:
undetectable		 1xwfA-4v1rA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 4v1r ALPHA-1,6-MANNANASE
(Bacteroides
thetaiotaomicron) 		3 / 3 TRP A 248
LEU A 246
LYS A 300
 None
 1.41A 1yajK-4v1rA:
undetectable		 1yajK-4v1rA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 4v1r ALPHA-1,6-MANNANASE
(Bacteroides
thetaiotaomicron) 		4 / 7 ALA A 155
TYR A 164
TYR A  91
TYR A  69
 None
 1.10A 2ajvH-4v1rA:
undetectable
2ajvL-4v1rA:
undetectable		 2ajvH-4v1rA:
20.50
2ajvL-4v1rA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4v1r ALPHA-1,6-MANNANASE
(Bacteroides
thetaiotaomicron) 		3 / 3 ASP A 328
ASP A 330
ASP A 321
 None
 0.76A 3douA-4v1rA:
undetectable		 3douA-4v1rA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 4v1r ALPHA-1,6-MANNANASE
(Bacteroides
thetaiotaomicron) 		4 / 7 ILE A  57
LEU A 374
TYR A  91
THR A  90
 None
 0.94A 3p50A-4v1rA:
undetectable		 3p50A-4v1rA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 4v1r ALPHA-1,6-MANNANASE
(Bacteroides
thetaiotaomicron) 		4 / 7 ILE A  57
LEU A 374
TYR A  91
THR A  90
 None
 0.94A 3p50B-4v1rA:
undetectable		 3p50B-4v1rA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 4v1r ALPHA-1,6-MANNANASE
(Bacteroides
thetaiotaomicron) 		4 / 7 ILE A  57
LEU A 374
TYR A  91
THR A  90
 None
 0.93A 3p50C-4v1rA:
undetectable		 3p50C-4v1rA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 4v1r ALPHA-1,6-MANNANASE
(Bacteroides
thetaiotaomicron) 		4 / 7 ILE A  57
LEU A 374
TYR A  91
THR A  90
 None
 0.94A 3p50D-4v1rA:
undetectable		 3p50D-4v1rA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 4v1r ALPHA-1,6-MANNANASE
(Bacteroides
thetaiotaomicron) 		4 / 7 ILE A  57
LEU A 374
TYR A  91
THR A  90
 None
 0.93A 3p50E-4v1rA:
undetectable		 3p50E-4v1rA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4v1r ALPHA-1,6-MANNANASE
(Bacteroides
thetaiotaomicron) 		4 / 7 SER A 103
ASP A 104
THR A  92
ILE A  95
 None
 0.87A 4acaC-4v1rA:
undetectable		 4acaC-4v1rA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4v1r ALPHA-1,6-MANNANASE
(Bacteroides
thetaiotaomicron) 		4 / 6 SER A 103
ASP A 104
THR A  92
ILE A  95
 None
 0.92A 4acbC-4v1rA:
undetectable		 4acbC-4v1rA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1490_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 4v1r ALPHA-1,6-MANNANASE
(Bacteroides
thetaiotaomicron) 		3 / 3 GLU A 298
TYR A 302
SER A 304
 None
 0.98A 4at0A-4v1rA:
undetectable		 4at0A-4v1rA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 4v1r ALPHA-1,6-MANNANASE
(Bacteroides
thetaiotaomicron) 		4 / 6 THR A 202
ALA A 206
LEU A 210
SER A 211
 None
 1.03A 4pwjA-4v1rA:
undetectable		 4pwjA-4v1rA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		 4v1r ALPHA-1,6-MANNANASE
(Bacteroides
thetaiotaomicron) 		4 / 7 THR A 202
ALA A 206
LEU A 210
SER A 211
 None
 0.99A 4pwjB-4v1rA:
undetectable		 4pwjB-4v1rA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4v1r ALPHA-1,6-MANNANASE
(Bacteroides
thetaiotaomicron) 		4 / 6 LEU A  87
SER A 377
PHE A 376
GLU A 359
 None
 1.13A 5b8iA-4v1rA:
undetectable		 5b8iA-4v1rA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		 4v1r ALPHA-1,6-MANNANASE
(Bacteroides
thetaiotaomicron) 		4 / 7 THR A 202
ALA A 206
LEU A 210
SER A 211
 None
 1.00A 5bojB-4v1rA:
undetectable		 5bojB-4v1rA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGO_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4v1r ALPHA-1,6-MANNANASE
(Bacteroides
thetaiotaomicron) 		4 / 4 VAL A 253
VAL A 198
TYR A 188
GLN A 190
 None
 1.48A 5qgoA-4v1rA:
undetectable		 5qgoA-4v1rA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGP_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4v1r ALPHA-1,6-MANNANASE
(Bacteroides
thetaiotaomicron) 		4 / 4 VAL A 253
VAL A 198
TYR A 188
GLN A 190
 None
 1.45A 5qgpA-4v1rA:
undetectable		 5qgpA-4v1rA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGQ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4v1r ALPHA-1,6-MANNANASE
(Bacteroides
thetaiotaomicron) 		4 / 4 VAL A 253
VAL A 198
TYR A 188
GLN A 190
 None
 1.49A 5qgqA-4v1rA:
undetectable		 5qgqA-4v1rA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHB_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4v1r ALPHA-1,6-MANNANASE
(Bacteroides
thetaiotaomicron) 		4 / 4 VAL A 253
VAL A 198
TYR A 188
GLN A 190
 None
 1.49A 5qhbA-4v1rA:
undetectable		 5qhbA-4v1rA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		 4v1r ALPHA-1,6-MANNANASE
(Bacteroides
thetaiotaomicron) 		4 / 6 ASN A 332
PRO A  37
ASP A 330
TYR A 327
 None
 1.03A 5umd2-4v1rA:
undetectable
5umdF-4v1rA:
undetectable		 5umd2-4v1rA:
13.04
5umdF-4v1rA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 4v1r ALPHA-1,6-MANNANASE
(Bacteroides
thetaiotaomicron) 		4 / 7 ILE A 320
LEU A 350
THR A  53
ARG A 375
 None
 1.05A 5vc0A-4v1rA:
undetectable		 5vc0A-4v1rA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 4v1r ALPHA-1,6-MANNANASE
(Bacteroides
thetaiotaomicron) 		5 / 10 GLU A 191
ALA A 171
GLU A 144
GLY A 146
ILE A 187
 None
 1.12A 6bniB-4v1rA:
undetectable		 6bniB-4v1rA:
12.09