SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4v20'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DY4_A_SNPA437_1
(EXOGLUCANASE 1)		 4v20 CELLOBIOHYDROLASE
(Aspergillus
fumigatus) 		12 / 12 ALA A 143
TYR A 145
TYR A 171
ASP A 173
SER A 174
GLN A 175
GLU A 212
ASP A 214
GLU A 217
THR A 246
ARG A 251
ASP A 376
 None
None
None
None
None
U63  A1443 (-4.4A)
None
None
U63  A1443 ( 4.3A)
U63  A1443 (-4.0A)
U63  A1443 (-3.0A)
U63  A1443 ( 4.9A)
 0.34A 1dy4A-4v20A:
65.2		 1dy4A-4v20A:
64.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DY4_A_SNPA437_2
(EXOGLUCANASE 1)		 4v20 CELLOBIOHYDROLASE
(Aspergillus
fumigatus) 		4 / 5 HIS A 228
TRP A 374
ALA A 379
TRP A 383
 U63  A1443 (-4.2A)
None
U63  A1443 ( 4.9A)
U63  A1443 (-3.6A)
 0.35A 1dy4A-4v20A:
65.2		 1dy4A-4v20A:
64.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_F_CCSF47_0
(GLUTATHIONE
S-TRANSFERASE)		 4v20 CELLOBIOHYDROLASE
(Aspergillus
fumigatus) 		4 / 5 THR A   5
LEU A  73
GLY A  75
TYR A 167
 ACT  A1444 (-3.9A)
PCA  A   1 ( 4.5A)
None
None
 1.26A 1gtiF-4v20A:
undetectable		 1gtiF-4v20A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 4v20 CELLOBIOHYDROLASE
(Aspergillus
fumigatus) 		6 / 12 PHE A 344
PHE A 263
TYR A 336
GLY A 329
SER A 322
GLY A 269
 None
 1.43A 1igxA-4v20A:
undetectable		 1igxA-4v20A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_A_STIA3_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4v20 CELLOBIOHYDROLASE
(Aspergillus
fumigatus) 		4 / 5 TYR A 109
VAL A 288
ILE A 428
MET A 367
 None
 1.29A 1opjA-4v20A:
undetectable		 1opjA-4v20A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		 4v20 CELLOBIOHYDROLASE
(Aspergillus
fumigatus) 		4 / 8 SER A 222
ASP A 385
ASN A 264
GLN A 268
 None
 1.13A 2cmlC-4v20A:
undetectable		 2cmlC-4v20A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 4v20 CELLOBIOHYDROLASE
(Aspergillus
fumigatus) 		5 / 12 GLN A 193
ASP A 241
GLY A 207
ASP A 179
SER A 248
 None
 1.31A 2nv4A-4v20A:
undetectable		 2nv4A-4v20A:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1002_0
(ALDEHYDE
DEHYDROGENASE A)		 4v20 CELLOBIOHYDROLASE
(Aspergillus
fumigatus) 		3 / 3 GLY A 168
ARG A  39
TYR A 109
 None
 0.83A 2opxA-4v20A:
undetectable		 2opxA-4v20A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4v20 CELLOBIOHYDROLASE
(Aspergillus
fumigatus) 		4 / 7 TYR A  82
GLN A 101
ILE A 104
SER A  99
 None
 1.14A 2xz5A-4v20A:
undetectable
2xz5B-4v20A:
undetectable		 2xz5A-4v20A:
19.50
2xz5B-4v20A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4v20 CELLOBIOHYDROLASE
(Aspergillus
fumigatus) 		4 / 8 TYR A  82
GLN A 101
ILE A 104
SER A  99
 None
 1.10A 2xz5B-4v20A:
undetectable
2xz5E-4v20A:
undetectable		 2xz5B-4v20A:
19.50
2xz5E-4v20A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4v20 CELLOBIOHYDROLASE
(Aspergillus
fumigatus) 		4 / 7 GLN A 101
ILE A 104
SER A  99
TYR A  82
 None
 1.13A 2xz5D-4v20A:
undetectable
2xz5E-4v20A:
undetectable		 2xz5D-4v20A:
19.50
2xz5E-4v20A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4v20 CELLOBIOHYDROLASE
(Aspergillus
fumigatus) 		4 / 7 TYR A 109
VAL A 288
ILE A 428
MET A 367
 None
 1.17A 3ik3A-4v20A:
undetectable		 3ik3A-4v20A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4v20 CELLOBIOHYDROLASE
(Aspergillus
fumigatus) 		4 / 7 TYR A 109
VAL A 288
ILE A 428
MET A 367
 None
 1.21A 3ik3B-4v20A:
undetectable		 3ik3B-4v20A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4v20 CELLOBIOHYDROLASE
(Aspergillus
fumigatus) 		3 / 3 TYR A 158
GLY A 154
ASP A 152
 None
 0.56A 3ou6C-4v20A:
undetectable		 3ou6C-4v20A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 4v20 CELLOBIOHYDROLASE
(Aspergillus
fumigatus) 		4 / 8 ASP A 214
GLY A 260
GLU A 217
ARG A 251
 None
None
U63  A1443 ( 4.3A)
U63  A1443 (-3.0A)
 0.98A 3s3nA-4v20A:
undetectable		 3s3nA-4v20A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 4v20 CELLOBIOHYDROLASE
(Aspergillus
fumigatus) 		4 / 4 LEU A 136
GLY A 142
MET A 381
PHE A  95
 None
 1.44A 3vaqB-4v20A:
undetectable		 3vaqB-4v20A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 4v20 CELLOBIOHYDROLASE
(Aspergillus
fumigatus) 		3 / 3 TYR A 247
ASP A 173
ASP A 257
 None
 0.80A 4a6eA-4v20A:
undetectable		 4a6eA-4v20A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4v20 CELLOBIOHYDROLASE
(Aspergillus
fumigatus) 		5 / 11 GLY A 170
ALA A 165
GLY A 153
MET A 149
VAL A 368
 None
 1.32A 4c5lA-4v20A:
undetectable		 4c5lA-4v20A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4v20 CELLOBIOHYDROLASE
(Aspergillus
fumigatus) 		5 / 10 GLY A 170
ALA A 165
GLY A 153
MET A 149
VAL A 368
 None
 1.29A 4c5lD-4v20A:
undetectable		 4c5lD-4v20A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4v20 CELLOBIOHYDROLASE
(Aspergillus
fumigatus) 		4 / 8 ASN A 141
GLY A 142
PHE A 129
ILE A 215
 None
 0.97A 4fglD-4v20A:
undetectable		 4fglD-4v20A:
19.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IPM_A_ACTA503_0
(GH7 FAMILY PROTEIN)		 4v20 CELLOBIOHYDROLASE
(Aspergillus
fumigatus) 		9 / 9 ASN A 141
ALA A 143
TYR A 145
TYR A 171
ASP A 173
GLU A 212
ASP A 214
GLU A 217
TRP A 374
 None
None
None
None
None
None
None
U63  A1443 ( 4.3A)
None
 0.49A 4ipmA-4v20A:
63.1		 4ipmA-4v20A:
55.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4v20 CELLOBIOHYDROLASE
(Aspergillus
fumigatus) 		3 / 3 ASN A 135
ASP A 132
ASP A 281
 None
 0.84A 4obwD-4v20A:
undetectable		 4obwD-4v20A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 4v20 CELLOBIOHYDROLASE
(Aspergillus
fumigatus) 		4 / 5 TYR A 171
SER A 372
ASP A 214
ASP A 262
 None
None
None
U63  A1443 ( 3.9A)
 1.06A 4qtuB-4v20A:
undetectable		 4qtuB-4v20A:
20.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 4v20 CELLOBIOHYDROLASE
(Aspergillus
fumigatus) 		5 / 5 GLY A   4
THR A   5
HIS A  42
GLY A  45
GLU A  74
 ACT  A1444 ( 3.7A)
ACT  A1444 (-3.9A)
ACT  A1444 (-4.6A)
ACT  A1444 (-3.8A)
ACT  A1444 ( 4.8A)
 0.00A 4v20A-4v20A:
75.5		 4v20A-4v20A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4v20 CELLOBIOHYDROLASE
(Aspergillus
fumigatus) 		5 / 12 GLY A 153
LEU A 108
TYR A 425
GLY A 105
THR A 169
 None
 1.12A 5eskA-4v20A:
undetectable		 5eskA-4v20A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4v20 CELLOBIOHYDROLASE
(Aspergillus
fumigatus) 		4 / 5 PRO A 177
HIS A 206
LEU A  73
TYR A  51
 None
None
PCA  A   1 ( 4.5A)
None
 1.47A 5igjA-4v20A:
undetectable		 5igjA-4v20A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		 4v20 CELLOBIOHYDROLASE
(Aspergillus
fumigatus) 		5 / 11 GLN A 186
ASP A 150
TYR A 171
PRO A 177
LEU A 180
 None
 1.23A 5jh7B-4v20A:
undetectable		 5jh7B-4v20A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		 4v20 CELLOBIOHYDROLASE
(Aspergillus
fumigatus) 		5 / 11 GLN A 186
ASP A 150
TYR A 171
PRO A 177
LEU A 180
 None
 1.21A 5jh7D-4v20A:
undetectable		 5jh7D-4v20A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 4v20 CELLOBIOHYDROLASE
(Aspergillus
fumigatus) 		4 / 6 THR A 246
ARG A 251
ASP A 250
GLY A 253
 U63  A1443 (-4.0A)
U63  A1443 (-3.0A)
None
None
 0.81A 5mraA-4v20A:
undetectable
5mraB-4v20A:
undetectable		 5mraA-4v20A:
16.82
5mraB-4v20A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 4v20 CELLOBIOHYDROLASE
(Aspergillus
fumigatus) 		5 / 9 VAL A  41
HIS A  42
ILE A 183
LEU A 180
ARG A  39
 None
ACT  A1444 (-4.6A)
None
None
None
 1.42A 6c2mC-4v20A:
undetectable		 6c2mC-4v20A:
12.56