SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4v23'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 4v23 MATRIX PROTEIN
(Respiratory
syncytial
virus) 		4 / 7 TYR A 236
VAL A 153
ILE A 152
GLU A   2
 None
 0.89A 1j96B-4v23A:
undetectable		 1j96B-4v23A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4v23 MATRIX PROTEIN
(Respiratory
syncytial
virus) 		5 / 12 MET A  84
LEU A  52
THR A  33
ILE A  34
SER A 198
 None
 1.06A 1xomB-4v23A:
undetectable		 1xomB-4v23A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4v23 MATRIX PROTEIN
(Respiratory
syncytial
virus) 		5 / 12 MET A  84
LEU A  52
THR A  33
ILE A  34
SER A 198
 None
 0.97A 1xoqA-4v23A:
undetectable		 1xoqA-4v23A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CB8_A_SAMA501_0
(PYRUVATE
FORMATE-LYASE
1-ACTIVATING ENZYME)		 4v23 MATRIX PROTEIN
(Respiratory
syncytial
virus) 		5 / 12 TYR A  20
ASN A  54
SER A  78
VAL A  18
LEU A 117
 None
 1.36A 3cb8A-4v23A:
undetectable		 3cb8A-4v23A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4v23 MATRIX PROTEIN
(Respiratory
syncytial
virus) 		5 / 12 ILE A 204
LEU A 226
PRO A 196
ASN A   6
LEU A   8
 None
 1.39A 3eigA-4v23A:
undetectable		 3eigA-4v23A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4v23 MATRIX PROTEIN
(Respiratory
syncytial
virus) 		5 / 12 MET A  84
LEU A  52
THR A  33
ILE A  34
SER A 198
 None
 1.07A 3g4lD-4v23A:
undetectable		 3g4lD-4v23A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4v23 MATRIX PROTEIN
(Respiratory
syncytial
virus) 		3 / 3 THR A 176
ASN A 175
GLU A 178
 None
 0.72A 3v4tA-4v23A:
undetectable
3v4tC-4v23A:
undetectable		 3v4tA-4v23A:
20.76
3v4tC-4v23A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		 4v23 MATRIX PROTEIN
(Respiratory
syncytial
virus) 		4 / 7 THR A  15
ALA A  17
SER A 116
THR A 118
 None
 0.58A 4pwjB-4v23A:
undetectable		 4pwjB-4v23A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		 4v23 MATRIX PROTEIN
(Respiratory
syncytial
virus) 		4 / 7 THR A  15
ALA A  17
SER A 116
THR A 118
 None
 0.74A 5bojB-4v23A:
undetectable		 5bojB-4v23A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Q1S_A_AWYA1103_0
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4v23 MATRIX PROTEIN
(Respiratory
syncytial
virus) 		4 / 6 LYS A   1
VAL A  22
LYS A 113
ILE A  57
 None
 1.12A 5q1sA-4v23A:
undetectable		 5q1sA-4v23A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4v23 MATRIX PROTEIN
(Respiratory
syncytial
virus) 		4 / 7 ALA A  16
THR A  15
GLN A  19
VAL A  18
 None
 0.92A 6cduA-4v23A:
undetectable
6cduE-4v23A:
undetectable		 6cduA-4v23A:
20.61
6cduE-4v23A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4v23 MATRIX PROTEIN
(Respiratory
syncytial
virus) 		4 / 7 GLN A  19
VAL A  18
ALA A  16
THR A  15
 None
 0.94A 6cduH-4v23A:
undetectable
6cduI-4v23A:
undetectable		 6cduH-4v23A:
20.61
6cduI-4v23A:
20.61