SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4v2d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 4v2d FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 2
(Homo
sapiens) 		4 / 8 ARG A 239
VAL A 238
ASN A 214
LYS A 168
 None
 1.21A 1hwiB-4v2dA:
undetectable		 1hwiB-4v2dA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_1
(ORPHAN NUCLEAR
RECEPTOR PXR)		 4v2d FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 2
(Homo
sapiens) 		5 / 12 VAL A 111
LEU A 129
GLN A 117
ILE A 124
PHE A 155
 None
 1.48A 1skxA-4v2dA:
undetectable		 1skxA-4v2dA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_2
(MINERALOCORTICOID
RECEPTOR)		 4v2d FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 2
(Homo
sapiens) 		4 / 6 LEU A 299
LEU A 332
LEU A 305
LEU A 325
 None
 0.83A 2ab2A-4v2dA:
undetectable		 2ab2A-4v2dA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 4v2d FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 2
(Homo
sapiens) 		5 / 9 ILE A 283
ILE A 267
PHE A 337
VAL A 295
LEU A 305
 None
 1.14A 2m9qA-4v2dA:
undetectable		 2m9qA-4v2dA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 4v2d FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 2
(Homo
sapiens) 		5 / 9 LEU A 281
ILE A 267
PHE A 337
VAL A 295
LEU A 305
 None
 1.14A 2m9qA-4v2dA:
undetectable		 2m9qA-4v2dA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)		 4v2d FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 2
(Homo
sapiens) 		5 / 9 ILE A 145
PHE A 155
ALA A 154
VAL A 150
GLU A 151
 None
 1.21A 2vufA-4v2dA:
undetectable		 2vufA-4v2dA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4v2d FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 2
(Homo
sapiens) 		5 / 12 PHE A 272
ILE A 267
VAL A 211
LEU A 209
ILE A 237
 None
 1.09A 3em0B-4v2dA:
undetectable		 3em0B-4v2dA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 4v2d FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 2
(Homo
sapiens) 		5 / 12 LEU A 291
GLN A 304
VAL A 350
VAL A 321
ILE A 328
 None
 1.13A 3gwxB-4v2dA:
undetectable		 3gwxB-4v2dA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		 4v2d FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 2
(Homo
sapiens) 		4 / 5 PRO A 179
SER A 160
LEU A 206
SER A 205
 None
 1.45A 3ijxH-4v2dA:
undetectable		 3ijxH-4v2dA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		 4v2d FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 2
(Homo
sapiens) 		4 / 5 PRO A 179
SER A 160
LEU A 206
SER A 205
 None
 1.31A 3iluH-4v2dA:
undetectable		 3iluH-4v2dA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 4v2d FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 2
(Homo
sapiens) 		3 / 3 ASP A 212
ARG A 239
ARG A 208
 None
 0.98A 3k37A-4v2dA:
undetectable		 3k37A-4v2dA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)		 4v2d FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 2
(Homo
sapiens) 		5 / 12 LEU A 281
LEU A 275
GLY A 251
THR A 252
LEU A 302
 None
 1.10A 3okxA-4v2dA:
undetectable		 3okxA-4v2dA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 4v2d FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 2
(Homo
sapiens) 		5 / 12 LEU A 281
LEU A 275
GLY A 251
THR A 252
LEU A 302
 None
 1.03A 3okxB-4v2dA:
undetectable		 3okxB-4v2dA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 4v2d FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 2
(Homo
sapiens) 		4 / 6 PHE A 226
LEU A 216
ALA A 199
LEU A 209
 None
 1.02A 3t3zD-4v2dA:
undetectable		 3t3zD-4v2dA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_B_ADNB401_1
(APH(2'')-ID)		 4v2d FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 2
(Homo
sapiens) 		4 / 8 PRO A 245
ILE A 264
LEU A 288
ILE A 267
 None
 0.94A 4dtaB-4v2dA:
undetectable		 4dtaB-4v2dA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 4v2d FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 2
(Homo
sapiens) 		4 / 6 PHE A 103
ALA A 128
ALA A 158
LEU A 132
 None
 0.83A 4dtzA-4v2dA:
undetectable		 4dtzA-4v2dA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 4v2d FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 2
(Homo
sapiens) 		4 / 6 PHE A 103
ALA A 128
ALA A 158
LEU A 132
 None
 0.85A 4dtzB-4v2dA:
undetectable		 4dtzB-4v2dA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 4v2d FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 2
(Homo
sapiens) 		4 / 7 PHE A 103
ALA A 128
ALA A 158
LEU A 132
 None
 0.82A 4du2A-4v2dA:
undetectable		 4du2A-4v2dA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 4v2d FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 2
(Homo
sapiens) 		4 / 7 PHE A 103
ALA A 128
ALA A 158
LEU A 132
 None
 0.81A 4du2B-4v2dA:
undetectable		 4du2B-4v2dA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4v2d FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 2
(Homo
sapiens) 		4 / 5 ARG A 191
VAL A 187
LEU A 166
SER A 167
 None
 1.04A 4e1gA-4v2dA:
undetectable		 4e1gA-4v2dA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		 4v2d FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 2
(Homo
sapiens) 		4 / 8 ILE A 192
PHE A 200
LEU A 209
PHE A 235
 None
 0.93A 4qopC-4v2dA:
undetectable		 4qopC-4v2dA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4v2d FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 2
(Homo
sapiens) 		4 / 5 GLY A 213
TYR A 258
SER A 236
GLU A 189
 None
 1.27A 4xueA-4v2dA:
undetectable		 4xueA-4v2dA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNW_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 4v2d FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 2
(Homo
sapiens) 		5 / 12 VAL A  47
LEU A 114
LEU A  95
LEU A 107
ARG A 112
 None
 1.09A 5hnwB-4v2dA:
undetectable		 5hnwB-4v2dA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNY_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4v2d FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 2
(Homo
sapiens) 		5 / 12 VAL A  47
LEU A 114
LEU A  95
LEU A 107
ARG A 112
 None
 1.12A 5hnyB-4v2dA:
undetectable		 5hnyB-4v2dA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)		 4v2d FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 2
(Homo
sapiens) 		5 / 12 LEU A  95
ALA A 128
PHE A 103
LEU A 116
LEU A 135
 None
 1.15A 6ew0G-4v2dA:
undetectable		 6ew0G-4v2dA:
13.80