SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4v2e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 4v2e FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3
(Mus
musculus) 		5 / 12 ILE A  52
LEU A 102
PRO A 103
VAL A 106
LEU A 109
 None
 0.81A 1df7A-4v2eA:
undetectable		 1df7A-4v2eA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_2
(ESTROGEN RECEPTOR)		 4v2e FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3
(Mus
musculus) 		4 / 6 LEU A 254
LEU A 283
LEU A 249
LEU A 227
 None
 0.93A 1errA-4v2eA:
undetectable		 1errA-4v2eA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		 4v2e FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3
(Mus
musculus) 		5 / 12 LEU A 230
LEU A 204
LEU A 180
LEU A 216
LEU A 211
 None
 1.13A 1sqnB-4v2eA:
undetectable		 1sqnB-4v2eA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_2
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 4v2e FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3
(Mus
musculus) 		3 / 3 ARG A 341
GLU A 338
GLN A 335
 None
 0.91A 2p16A-4v2eA:
undetectable		 2p16A-4v2eA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4v2e FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3
(Mus
musculus) 		5 / 12 ASN A  71
LEU A  95
LEU A  90
ILE A  75
LEU A  79
 None
 1.12A 3fl9G-4v2eA:
undetectable		 3fl9G-4v2eA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 4v2e FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3
(Mus
musculus) 		5 / 9 PHE A 150
LEU A 135
VAL A 140
LEU A 124
ILE A 119
 None
 1.03A 3tbgD-4v2eA:
undetectable		 3tbgD-4v2eA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_1
(METHYLTRANSFERASE
MPPJ)		 4v2e FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3
(Mus
musculus) 		3 / 3 ARG A 330
ASP A 277
ASP A 256
 None
 0.85A 4kicB-4v2eA:
undetectable		 4kicB-4v2eA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 4v2e FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3
(Mus
musculus) 		5 / 12 ILE A 187
ILE A 145
LEU A 173
LEU A 180
ILE A 169
 None
 1.01A 4m2xC-4v2eA:
undetectable		 4m2xC-4v2eA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 4v2e FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3
(Mus
musculus) 		5 / 10 LEU A  90
LEU A 102
ILE A 127
LEU A 156
PHE A  98
 None
 1.05A 4odoA-4v2eA:
undetectable		 4odoA-4v2eA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 4v2e FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3
(Mus
musculus) 		5 / 10 LEU A  90
LEU A 102
ILE A 127
LEU A 156
PHE A  98
 None
 1.00A 4odoB-4v2eA:
undetectable		 4odoB-4v2eA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_C_FK5C204_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 4v2e FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3
(Mus
musculus) 		5 / 10 LEU A  90
LEU A 102
ILE A 127
LEU A 156
PHE A  98
 None
 1.01A 4odoC-4v2eA:
undetectable		 4odoC-4v2eA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4v2e FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3
(Mus
musculus) 		4 / 7 ILE A 169
PHE A 221
GLY A 217
LEU A 237
 None
 1.03A 5esmA-4v2eA:
undetectable		 5esmA-4v2eA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 4v2e FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3
(Mus
musculus) 		4 / 8 ILE A 177
PRO A 174
ILE A 119
LEU A 204
 None
 0.76A 5ieoA-4v2eA:
undetectable		 5ieoA-4v2eA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 4v2e FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3
(Mus
musculus) 		4 / 8 ILE A 177
PRO A 174
ILE A 145
LEU A 204
 None
 0.90A 5ieoA-4v2eA:
undetectable		 5ieoA-4v2eA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 4v2e FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3
(Mus
musculus) 		5 / 9 ILE A 177
PRO A 174
VAL A 140
ILE A 145
LEU A 204
 None
 1.15A 5iepA-4v2eA:
undetectable		 5iepA-4v2eA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_B_STRB502_1
(CYTOCHROME P450
CYP260A1)		 4v2e FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3
(Mus
musculus) 		4 / 6 LEU A 102
LEU A 133
SER A 123
ASN A 138
 None
 0.81A 6f88B-4v2eA:
undetectable		 6f88B-4v2eA:
12.54