SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4v2i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 4v2i ESTERASE/LIPASE
(Thalassospira
sp.
GB04J01) 		5 / 12 GLY A  85
GLY A  87
SER A 158
PHE A 215
HIS A 285
 None
 0.83A 1dx6A-4v2iA:
18.3		 1dx6A-4v2iA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK5_A_T44A1008_1
(SERUM ALBUMIN)		 4v2i ESTERASE/LIPASE
(Thalassospira
sp.
GB04J01) 		5 / 10 ASP A 131
ALA A 133
GLU A 117
VAL A  65
VAL A  57
 None
 1.09A 1hk5A-4v2iA:
1.6		 1hk5A-4v2iA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 4v2i ESTERASE/LIPASE
(Thalassospira
sp.
GB04J01) 		5 / 10 GLY A 160
LEU A  99
TYR A  82
THR A 164
GLY A 161
 None
 1.02A 1kvlA-4v2iA:
undetectable		 1kvlA-4v2iA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		 4v2i ESTERASE/LIPASE
(Thalassospira
sp.
GB04J01) 		5 / 12 GLY A  85
GLY A  87
SER A 158
PHE A 215
HIS A 285
 None
 0.84A 1qtiA-4v2iA:
2.7		 1qtiA-4v2iA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4v2i ESTERASE/LIPASE
(Thalassospira
sp.
GB04J01) 		5 / 12 VAL A 112
ALA A 107
LEU A 103
ALA A 155
ALA A 181
 None
 1.18A 1sa1C-4v2iA:
2.9
1sa1D-4v2iA:
4.0		 1sa1C-4v2iA:
20.72
1sa1D-4v2iA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		 4v2i ESTERASE/LIPASE
(Thalassospira
sp.
GB04J01) 		5 / 12 GLY A  85
GLY A  87
SER A 158
PHE A 215
HIS A 285
 None
 0.84A 1w6rA-4v2iA:
18.2		 1w6rA-4v2iA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4v2i ESTERASE/LIPASE
(Thalassospira
sp.
GB04J01) 		5 / 12 LEU A 207
LEU A 290
GLY A  87
ALA A  86
LEU A  35
 None
 1.05A 2aylA-4v2iA:
undetectable		 2aylA-4v2iA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4v2i ESTERASE/LIPASE
(Thalassospira
sp.
GB04J01) 		5 / 12 LEU A 207
LEU A 290
GLY A  87
ALA A  86
LEU A  35
 None
 1.04A 2aylB-4v2iA:
undetectable		 2aylB-4v2iA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_B_ANWB99_0
(PROTEIN S100-A13)		 4v2i ESTERASE/LIPASE
(Thalassospira
sp.
GB04J01) 		4 / 8 ALA A 236
VAL A 166
THR A 189
ASP A 228
 None
 1.19A 2kotB-4v2iA:
undetectable		 2kotB-4v2iA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)		 4v2i ESTERASE/LIPASE
(Thalassospira
sp.
GB04J01) 		5 / 12 LEU A  99
GLY A 160
GLY A 161
THR A 164
LEU A 103
 None
 1.16A 2uvnA-4v2iA:
undetectable		 2uvnA-4v2iA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_B_LLTB261_1
(DEOXYCYTIDINE KINASE)		 4v2i ESTERASE/LIPASE
(Thalassospira
sp.
GB04J01) 		4 / 7 VAL A 288
LEU A  99
TYR A  82
LEU A 310
 None
 1.05A 3qeoB-4v2iA:
undetectable		 3qeoB-4v2iA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 4v2i ESTERASE/LIPASE
(Thalassospira
sp.
GB04J01) 		3 / 3 THR A 251
ASP A 259
GLU A 200
 MG  A1317 (-4.0A)
None
None
 0.76A 3qowA-4v2iA:
undetectable		 3qowA-4v2iA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA452_1
(CYTOCHROME P450
164A2)		 4v2i ESTERASE/LIPASE
(Thalassospira
sp.
GB04J01) 		5 / 12 PRO A  78
LEU A 314
ALA A 109
LEU A 111
LEU A  99
 None
 1.17A 3r9cA-4v2iA:
undetectable		 3r9cA-4v2iA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4v2i ESTERASE/LIPASE
(Thalassospira
sp.
GB04J01) 		3 / 3 TYR A 116
GLU A 129
TYR A 132
 None
 0.99A 3ug8A-4v2iA:
undetectable		 3ug8A-4v2iA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 4v2i ESTERASE/LIPASE
(Thalassospira
sp.
GB04J01) 		4 / 8 ARG A  32
TYR A 116
GLU A 117
HIS A  84
 None
 1.39A 3zmdA-4v2iA:
undetectable
3zmdB-4v2iA:
undetectable		 3zmdA-4v2iA:
18.04
3zmdB-4v2iA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		 4v2i ESTERASE/LIPASE
(Thalassospira
sp.
GB04J01) 		5 / 12 GLY A  85
GLY A  87
SER A 158
PHE A 215
HIS A 285
 None
 0.84A 4ey6A-4v2iA:
19.0		 4ey6A-4v2iA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		 4v2i ESTERASE/LIPASE
(Thalassospira
sp.
GB04J01) 		5 / 12 GLY A  85
GLY A  87
SER A 158
PHE A 215
HIS A 285
 None
 0.83A 4ey6B-4v2iA:
18.4		 4ey6B-4v2iA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_F_CAMF502_0
(CAMPHOR
5-MONOOXYGENASE)		 4v2i ESTERASE/LIPASE
(Thalassospira
sp.
GB04J01) 		4 / 4 TYR A 219
THR A 232
VAL A 188
ILE A 128
 None
 1.46A 4jx1F-4v2iA:
undetectable		 4jx1F-4v2iA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 4v2i ESTERASE/LIPASE
(Thalassospira
sp.
GB04J01) 		4 / 8 ALA A 107
THR A 135
VAL A 167
PHE A  83
 None
 1.02A 4ltwA-4v2iA:
undetectable		 4ltwA-4v2iA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		 4v2i ESTERASE/LIPASE
(Thalassospira
sp.
GB04J01) 		4 / 5 LEU A 257
ASP A 190
TRP A 216
ILE A 231
 None
 1.21A 4mwrA-4v2iA:
undetectable		 4mwrA-4v2iA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4v2i ESTERASE/LIPASE
(Thalassospira
sp.
GB04J01) 		5 / 12 LEU A 290
ASP A 286
SER A 158
PHE A 215
LEU A  26
 None
 1.12A 4nc3A-4v2iA:
undetectable		 4nc3A-4v2iA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_2
(PROTEASE)		 4v2i ESTERASE/LIPASE
(Thalassospira
sp.
GB04J01) 		5 / 9 ASP A 259
GLY A 196
ASP A 192
ASP A 190
THR A 251
 None
None
None
None
MG  A1317 (-4.0A)
 1.16A 4njtD-4v2iA:
undetectable		 4njtD-4v2iA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4v2i ESTERASE/LIPASE
(Thalassospira
sp.
GB04J01) 		5 / 12 SER A  36
GLY A  85
ASP A 157
MET A 163
ASP A 115
 None
 1.40A 4pghB-4v2iA:
3.0		 4pghB-4v2iA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4v2i ESTERASE/LIPASE
(Thalassospira
sp.
GB04J01) 		5 / 9 LEU A 207
LEU A 290
GLY A  87
ALA A  86
LEU A  35
 None
 1.08A 4rs0A-4v2iA:
undetectable		 4rs0A-4v2iA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTR_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 4v2i ESTERASE/LIPASE
(Thalassospira
sp.
GB04J01) 		5 / 11 GLY A  85
PHE A 287
ILE A 303
TYR A 280
ASP A 286
 None
 1.46A 4rtrA-4v2iA:
undetectable		 4rtrA-4v2iA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 4v2i ESTERASE/LIPASE
(Thalassospira
sp.
GB04J01) 		5 / 12 LEU A 314
ALA A 107
LEU A 103
ALA A 155
ALA A 181
 None
 1.00A 4x20B-4v2iA:
3.8		 4x20B-4v2iA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXF_A_BEZA601_0
(EUGENOL OXIDASE)		 4v2i ESTERASE/LIPASE
(Thalassospira
sp.
GB04J01) 		5 / 9 TYR A  82
VAL A 288
ILE A 250
VAL A 183
LEU A 310
 None
 1.36A 5fxfA-4v2iA:
0.5		 5fxfA-4v2iA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXF_B_BEZB601_0
(EUGENOL OXIDASE)		 4v2i ESTERASE/LIPASE
(Thalassospira
sp.
GB04J01) 		5 / 10 TYR A  82
VAL A 288
ILE A 250
VAL A 183
LEU A 310
 None
 1.37A 5fxfB-4v2iA:
undetectable		 5fxfB-4v2iA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4v2i ESTERASE/LIPASE
(Thalassospira
sp.
GB04J01) 		5 / 12 LEU A  99
GLY A  94
LEU A 103
SER A 104
HIS A  84
 None
 0.92A 5twjA-4v2iA:
undetectable		 5twjA-4v2iA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 4v2i ESTERASE/LIPASE
(Thalassospira
sp.
GB04J01) 		5 / 12 LEU A 145
PHE A  55
ILE A  67
ALA A 153
ILE A 179
 None
 1.03A 5veuB-4v2iA:
undetectable		 5veuB-4v2iA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 4v2i ESTERASE/LIPASE
(Thalassospira
sp.
GB04J01) 		4 / 7 TRP A 216
SER A 158
GLY A 160
LEU A 257
 None
 1.03A 6btxA-4v2iA:
undetectable		 6btxA-4v2iA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4v2i ESTERASE/LIPASE
(Thalassospira
sp.
GB04J01) 		5 / 12 ALA A 181
LEU A 152
VAL A  65
VAL A  57
ALA A 171
 None
 1.10A 6djzC-4v2iA:
undetectable		 6djzC-4v2iA:
20.48