SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4v2p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 4v2p KETOSYNTHASE
(Myxococcus
fulvus) 		5 / 12 ALA A 301
GLY A 321
THR A 320
VAL A 270
LEU A 271
 None
 1.07A 1jipA-4v2pA:
undetectable		 1jipA-4v2pA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_1
(PROTEASE)		 4v2p KETOSYNTHASE
(Myxococcus
fulvus) 		5 / 10 ALA A 119
VAL A 329
GLY A 295
ILE A 294
THR A 322
 None
None
None
MPD  A1340 (-4.5A)
None
 1.16A 3el5A-4v2pA:
undetectable		 3el5A-4v2pA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 4v2p KETOSYNTHASE
(Myxococcus
fulvus) 		5 / 12 GLY A 295
PRO A 299
ALA A 171
ALA A 170
SER A 324
 None
None
None
None
MPD  A1339 (-3.3A)
 1.23A 3mteA-4v2pA:
undetectable		 3mteA-4v2pA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 4v2p KETOSYNTHASE
(Myxococcus
fulvus) 		5 / 12 GLY A 295
GLY A  88
ALA A 170
ALA A 171
LEU A 122
 None
 0.93A 3p2kA-4v2pA:
undetectable		 3p2kA-4v2pA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 4v2p KETOSYNTHASE
(Myxococcus
fulvus) 		5 / 12 GLY A 295
GLY A  88
ALA A 170
ALA A 171
LEU A 122
 None
 0.94A 3p2kC-4v2pA:
undetectable		 3p2kC-4v2pA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 4v2p KETOSYNTHASE
(Myxococcus
fulvus) 		5 / 12 GLY A 295
GLY A  88
ALA A 170
ALA A 171
LEU A 122
 None
 0.98A 3p2kD-4v2pA:
undetectable		 3p2kD-4v2pA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA502_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 4v2p KETOSYNTHASE
(Myxococcus
fulvus) 		5 / 8 THR A 320
LEU A 246
TRP A 247
VAL A 332
VAL A 318
 None
 1.27A 4em2A-4v2pA:
undetectable		 4em2A-4v2pA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8W_G_MTXG301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 4v2p KETOSYNTHASE
(Myxococcus
fulvus) 		5 / 9 GLY A 323
GLY A 321
CYH A 121
LEU A 122
GLN A 265
 MPD  A1339 ( 4.4A)
None
MPD  A1339 (-4.2A)
None
None
 1.29A 4l8wG-4v2pA:
undetectable		 4l8wG-4v2pA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4v2p KETOSYNTHASE
(Myxococcus
fulvus) 		4 / 6 LEU A 319
GLU A 129
VAL A 117
ALA A  86
 None
 0.88A 4nkxA-4v2pA:
undetectable		 4nkxA-4v2pA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)		 4v2p KETOSYNTHASE
(Myxococcus
fulvus) 		4 / 6 LEU A  26
ARG A  50
ARG A  51
ARG A  48
 None
 1.05A 5l6eA-4v2pA:
undetectable
5l6eB-4v2pA:
undetectable		 5l6eA-4v2pA:
20.13
5l6eB-4v2pA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUK_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 4v2p KETOSYNTHASE
(Myxococcus
fulvus) 		5 / 10 ALA A  66
ILE A  84
ILE A 143
VAL A 175
ALA A  69
 None
 1.21A 5nukA-4v2pA:
undetectable		 5nukA-4v2pA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_0
(REGULATORY PROTEIN
TETR)		 4v2p KETOSYNTHASE
(Myxococcus
fulvus) 		5 / 12 ALA A 151
LEU A 224
ARG A 158
TYR A  34
ASP A 221
 MPD  A1340 ( 4.3A)
MPD  A1340 ( 4.0A)
None
None
None
 1.34A 5vlmC-4v2pA:
undetectable		 5vlmC-4v2pA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4v2p KETOSYNTHASE
(Myxococcus
fulvus) 		5 / 12 PHE A 333
TYR A 273
LEU A 274
ILE A 262
MET A 298
 None
 1.13A 5y2tB-4v2pA:
undetectable		 5y2tB-4v2pA:
undetectable